Clinical study of 200 patients with recurrent aphthous stomatitis

Abstract

Introduction: Recurrent aphthous stomatitis (RAS) affects approximately 20% of the general population. Its etiology is still unknown. Objective: To analyze this entity's clinical features. Method: Data such as age, gender, family history of RAS, age at first episode onset, prodromal symptoms, number, size, morphology and localization of lesions, RAS clinical form, annual rate of recurrence, predisposing factors, symptoms and time for symptoms and lesions disappearance were assessed in 200 patients with RAS. Results: Patients had RAS minor forms. Main clinical characteristics were family history of RAS ( 89%), first episode at ≥ 10 years of age (69%), prodromal symptoms (66%), one lesion per episode (63%), < 0.5 cm lesions (64%), rounded morphology (55%), localization at the tongue (27%), 3 recurrent episodes per year (36%), stress as predisposing factor (34%), symptom disappearance in 2 days (54%) and healing of lesions in 8 days (40%). Conclusion: Even when RAS is a common disorder of the oral mucosa, there is no curative treatment available. Therapeutic measures seek to reduce the pain and size of lesions, accelerate the time of recovery and decrease the rate of relapses.

The Role of Stress in Recurrent Aphthous Stomatitis

“…21 These findings are similar to a study conducted by Rathod et al, which concluded that the ulcers healed within 2 to 5 days in most patients (96.36%). 19 Meanwhile, this study is slightly different from the study by Hedge et al 18 and Rodriguez-Archilla et al 22 Hedge et al recorded that ulcers healed in less than 1 week in 46.2% of patients, in 1 to 2 weeks in 38% of patients, and in more than 2 weeks in 15.8% of patients. 18 In the study by Rodriguez-Archilla et al comprising 200 individuals with recurrent aphthous stomatitis, 49% of lesions healed in less than 7 days and 51% in more than 7 days.…”

“…18 In the study by Rodriguez-Archilla et al comprising 200 individuals with recurrent aphthous stomatitis, 49% of lesions healed in less than 7 days and 51% in more than 7 days. 22 The duration required for healing of the ulcer depends on the type of ulcer. The process of oral ulcer healing involves four phases: hemostasis, inflammation, proliferation, and remodeling.…”

Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital

“…Recurrent aphthous stomatitis (RAS) is the commonly found oral lesion in the community, with nearly 10-30% of the population are affected. 17,18,19,20 Evidently, RAS was found in 55% among all the oral ulceration cases (Figure 3). Following RAS, traumatic ulcer (TU) came next with 43% from the oral ulcerative diagnosis, and angular cheilitis (AC) came third with 2% ( Figure 3).…”

Predisposing Factors for Recurrent Aphthous Stomatitis among Undergraduate Dental Students

“…1 This is also supported by Rodríguez-Archilla and Raissouni, whose statistical analysis shows that RAS is more common in females than males. 14 In addition, the study conducted by Sulistiani et al also states that RAS is more common in females than males, with approximately 70.0% of RAS patients being female. 15 The same was also revealed in Abdullah's research, which found that the majority of RAS patients were female (55.4%).…”