Clinical Studies With Tolmetin: Open Study and a Double-Blind Cross-Over Comparison With Aspirin in Rheumatoid Arthritis

Ansell, B. M.; Carter, M. E.; Gumpel, J M; Meanock, I.; Rosenburg, Jared; Steele, Christine E.

doi:10.1093/rheumatology/17.3.150

Cited by 2 publications

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“…Of these, 33 concerned patients with rheumatoid arthritis (RA)2-34 and 15 concerned patients with osteoarthritis (OA).35d9 One study was of patients with systemic lupus erythematosus (SLE)50 and 3 were of patients with juvenile rheumatoid arthritis (JRA).51-53 A parallel design was used in 27 studies and a crossover design in 25. In 18 studies the treatment groups contained at least 50 patients; however, 23 studies had fewer than 30 patients per group and of these 12 had fewer than 20 patients per group. All studies contained at least 10 patients per treatment group.…”

Section: Resultsmentioning

confidence: 99%

Nonsteroidal Antiinflammatory Drugs and Aspirin—Analyzing the Scores

Heller¹,

Ingelfinger²,

Goldman³

1985

Pharmacotherapy

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We reviewed 103 controlled clinical trials that compared the antiarthritic efficacy and tolerance of previously and currently marketed nonsteroidal antiinflammatory drugs (NSAIDs) and aspirin. Of 52 studies, 35 had data sufficient to calculate an NSAID efficacy index (the ratio of mean improvement in NSAID-treated patients to that in aspirin-treated patients) based on subjective and/or objective criteria. The mean indexes (obtained from all studies from which an index could be calculated) indicated no statistically significant difference in efficacy between aspirin and the NSAIDs as a group; the indexes tended to become less variable as the number of study subjects increased. Tolerance, assessed from the percentage of patients who discontinued the drug because of side effects, was significantly greater for NSAIDs than for aspirin. The NSAIDs had greater efficacy but not greater toxicity at increased doses. Efficacy differences described among NSAIDs in some studies were attributable either to comparisons at nonequivalent doses or to chance.

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Section: Resultsmentioning

confidence: 99%

Nonsteroidal Antiinflammatory Drugs and Aspirin—Analyzing the Scores

Heller¹,

Ingelfinger²,

Goldman³

1985

Pharmacotherapy

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A Reevaluation of Aspirin Therapy in Rheumatoid Arthritis

Fries¹

1993

Arch Intern Med

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Aspirin therapy, in doses commonly employed in practice, has an excellent safety profile in rheumatoid arthritis, and it is the least costly NSAID. The safety advantage is explained primarily by a dose effect and secondarily by possible differences between formulations. Newer management strategies for rheumatoid arthritis emphasize NSAID use as symptomatic therapy and use of disease-modifying anti-rheumatic drug therapy for anti-inflammatory objectives. Thus, the original recommendation for "anti-inflammatory" doses of aspirin now is less easily justified. Aspirin therapy merits reconsideration as adjunctive therapy for the management of rheumatoid arthritis.

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Clinical Studies With Tolmetin: Open Study and a Double-Blind Cross-Over Comparison With Aspirin in Rheumatoid Arthritis

Cited by 2 publications

References 0 publications

Nonsteroidal Antiinflammatory Drugs and Aspirin—Analyzing the Scores

Nonsteroidal Antiinflammatory Drugs and Aspirin—Analyzing the Scores

A Reevaluation of Aspirin Therapy in Rheumatoid Arthritis

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