Clinical Studies of Induction Agents: Xlii: Influence of Injection Rate and Dosage on the Induction Complications With Althesin

Samuel, I.O.; Dundee, John W.

doi:10.1093/bja/45.12.1215

Cited by 7 publications

(4 citation statements)

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“…anaesthetic agents it is not surprising that altering the solvent had no significant effect on their frequency and it seems unlikely that they are related to pain on injection. A fast rate of injection did not increase the frequency of muscle movement as was found by Barron (1968) with methohexitone and Samuel and Dundee (1973) with Althesin. However, it is claimed that the frequency can be reduced by sedative premedication (Holdcroft et al, 1976) and further studies to examine this aspect are in progress.…”

Section: Discussionsupporting

confidence: 67%

“…We have compared the effects of the three solutions which have been available for study, in unpremedicated patients at a standard dose of 0.3 mg kg" 1 as recommended by Doenicke, Wagner and Beetz (1973). Two rates of injection were used to see if the sideeffects, like those of the barbiturates and Althesin (Barron, 1968;Samuel and Dundee, 1973), were influenced by this factor. reports.…”

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confidence: 99%

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Evaluation of Three Preparations of Etomidate

Zacharias¹,

Clarke²,

Dundee³

et al. 1978

British Journal of Anaesthesia

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Three formulations of etomidate were evaluated in unpremedicated patients undergoing minor gynaecological procedures. There was a high frequency of pain on injection (up to 50%) and excitatory phenomena (up to 95%) with all formulations. The frequency of excitatory phenomena was significantly greater than that after methohexitone. Recovery was rapid, but emetic sequelae were frequent and significantly more marked than after methohexitone.

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Section: Discussionsupporting

confidence: 67%

mentioning

confidence: 99%

Evaluation of Three Preparations of Etomidate

Zacharias¹,

Clarke²,

Dundee³

et al. 1978

British Journal of Anaesthesia

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“…of an uneventful Althesin anaesthetic completed in a patient who had exhibited a marked flush on a previous occasion. Anxiety of the patient, rate of injection (Samuel and Dundee, 1973), distribution within the brain, and perhaps other variables could lead to an exaggeration of otherwise insignificant effects.…”

Section: Discussionmentioning

confidence: 99%

ADVERSE REACTIONS TO INTRAVENOUS ANAESTHETICS: A Survey of 100 Reports

Clarke¹,

Dundee²,

Garrett³

et al. 1975

British Journal of Anaesthesia

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143

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One hundred consecutive reports of reactions to intravenous anaesthetics Althesin, thiopentone and Epontol are reviewed and analysed. Ten reactions are attributed to causes other than the anaesthetic drug, and four are believed to have been caused by the muscle relaxant employed. The remaining 86 reactions were grouped according to their clinical presentation: histaminoid reactions ( 19), histaminoid with bronchospasm (33), bronchospasm (12), cardiovascular collapse (uu), delayed histaminoid reactions (6), and clonic contractions (5). None of the first four reaction types was associated with only one anaesthetic. A knowledge of the sales of Althesin has allowed the incidence of reactions to be estimated as between one in 11,000 and one in 19,000.

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“…Clonic muscular movements following induction with althesin are a recognized complication especially in response to stimulation (Swerdlow, Chakreborty and Zahangir 1971). Suoh reactions seem to be related to dose, rate of injection, and premedication (Samuel andDundee 1973, Clarke et al 1972). However, EEGs taken during such clonic movements have not shown spike activity (Laxenaire et al 1974).…”

Section: Discussionmentioning

confidence: 99%