Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Cormedi, Marina Candido Visontai; Lopes, E. F.; Maistro, Simone; Roela, Rosimeire Aparecida; Folgueira, Maria Aparecida Azevedo Koike

doi:10.6061/clinics/2018/e656s

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…The most common malignancies are the invasive carcinomas of NST (87.12%) and ductal carcinoma in situ (3.68%), similar to other studies from Africa [ 26 , 27 ], Brazil [ 28 ], and England [ 29 ]. More than half of the cases were of grade 3 and very few were of grade 1, which agrees with a study by Stalk et al [ 30 ] but contrasts with another by Eugenio et al [ 28 ]. High grade tumors have poor prognosis [ 31 , 32 ].…”

Section: Discussionsupporting

confidence: 87%

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The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana

Ameh-Mensah

Duduyemi

Bedu-Addo

et al. 2021

Journal of Oncology

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Background. Little is known about the role of apoptosis in the tumorigenesis and prognosis of breast cancer in Ghana. Chemotherapeutic drug efficacy partially relates to apoptosis induction, rendering it a vital target in cancer therapy with unique biomarker opportunities that have not been exploited. Aberrations in this pathway are central to tumorigenesis, tumor progression, overall tumor growth, and regression during treatment therapies. Antiapoptotic bcl-2 (gene) and p53 are known to play roles in apoptosis while Ki-67 is a proliferative marker. The aim of our study is to determine the association of bcl-2 (protein) with p53 and Ki-67 in 203 consecutive breast cancer cases over a 10-year period. Method. A retrospective cross-sectional study on archival FFPE tissue blocks over a 9-year period with abstraction of clinicopathologic data. Two hundred and three consecutive and suitable FFPE blocks were selected for tissue microarray (TMA) construction, and IHC (bcl-2 (protein), Ki-67, p53, cyclin D, pan cytokeratins A and E, ER, PR, and HER2/neu) was done. Expressions of bcl-2 (protein), p53, and Ki-67 were related to histological grade, lymphovascular invasion, and molecular subtypes. SPSS version 23 was used to analyze results. Results. Most of our cases were in the fifth decade of life (31%); invasive carcinoma of no special type (NST) was predominant (87%); histological grade III (38%) was the highest; and Luminal A (19.8%), Luminal B (9.9%), HER2 (16%), and TNBC (54.3%) constituted the molecular classes. bcl-2 expression was found in 38% of the cases. Our cases also showed mutation in p53 (36.7%) and ki-67 expression (62.5%). bcl-2 (protein) and p53 significantly correlated with Luminal B and TNBC ( p < 0.01 ). Ki-67 also correlated significantly with Luminal A and B and HER2 overexpression ( p < 0.01 ). Premenopausal age (40–49) and histological grade inversely correlated with bcl-2 (protein) expression. p53 statistically correlated with Ki-67 ( p < 0.05 ). Conclusion. Our results show high expression of bcl-2 (protein) suggesting an important role of apoptosis in Ghanaian breast cancer cases. bcl-2 (protein), p53, and Ki-67 expressions emerged interdependently from this research and can thus be manipulated in prediction and prognosis of breast cancers in our setting.

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Section: Discussionsupporting

confidence: 87%

“…In this study, about half of our cases showed lymphovascular involvement or invasion which primarily indicates poor prognosis [ 28 , 33 ]. The number of affected lymph nodes, which we have no data on, may as well be of prognostic importance.…”

Section: Discussionmentioning

confidence: 99%

The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana

Ameh-Mensah

Duduyemi

Bedu-Addo

et al. 2021

Journal of Oncology

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“…The present results are in accordance with other authors, who have shown that lung cancer in YA is more commonly detected in women and that adenocarcinoma is more prevalent than in older patients [5,11,14]. In addition, more advanced CS at diagnosis seems to be a trend in young patients [19]. Accordingly, among patients aged 40 years or less, a greater proportion (63.2%, compared with 51.9% of MA and 43.2% of elderly patients, after excluding around 5% of the patients with undetermined CS) in the present series and 57.4% in a surveillance, epidemiology, and end results (SEER) study (compared with 43% of elderly individuals) were diagnosed with disease CS IV [5].…”

Section: Discussionsupporting

confidence: 93%

Survival analysis of young adults from a Brazilian cohort of non-small cell lung cancer patients

Nicolau

López

Luizaga

et al. 2021

ecancer

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Background:The influence of age at diagnosis in non-small cell lung cancer (NSCLC) prognosis is unclear.Objectives: To compare in a Brazilian cohort of NSCLC patients of different age groups: 1) The overall survival; 2) Clinical features and treatment options.Methods: This is a retrospective cohort study using a hospital-based registry, for NSCLC patients registered in years 2000-2009. Patients were grouped into three age groups: Young adults (YA: < 40 years), middle-aged (MA: 40-64 years) and elderly (E: ≥ 65 years). Kaplan-Meier was used to estimate overall survival and Cox regression for hazard ratios (HRs) and 95% confidence intervals.Results: 17,422 NSCLC patients were included: 370 YA (2.1%), 8,697 MA (49.9%) and 8,355 E (48.0%). Compared with older age groups, the YA group had a higher proportion of females, patients diagnosed with adenocarcinoma and metastatic disease (63.2%). Overall survival was longer in YA in the entire cohort and in all clinical stages (CSs) (p < 0.001). For YA, higher education level was a good prognosis factor (compared with illiterate and incomplete elementary); advanced or metastatic disease (compared with early-stage disease) and treatment based in radiotherapy or chemotherapy (CT) (without surgery), compared with treatment combinations with surgery, were poor prognostic factors. Young men (but not women) had lower HR of death compared with older groups; YA had lower HR of death in all CSs compared with patients from older groups. A higher percentage of YA were treated with surgery or CT in early-stage disease compared with older groups. Besides that, YA and MA patients treated with surgery or CT had a better prognosis than elderlies. Conclusions: In this Brazilian cohort of NSCLC patients, most young individuals were diagnosed with metastatic disease. YA presented longer survival than older age groups in all CSs, but mainly in CS I/II and III, where some patients may achieve long remissions or cure.

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“…Patients in this age group had no history of alcohol consumption, cigarette smoking, comorbidity, or family history of cancer. Indeed, recent reports have also noted rising cases of CRC among adolescents and young adults (AYAs), [34][35][36][37] and the most commonly involved sites were the distal colon and rectum. 35,38 Unfortunately, the factors influencing this rise are yet to be determined.…”

Section: Dovepressmentioning

confidence: 99%

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

Wekha

Ssewante

Iradukunda

et al. 2021

CMAR

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Introduction:Colorectal cancer (CRC) is the most common type of gastrointestinal malignancies and the third leading cause of cancer-related deaths for both sexes worldwide. Although the burden of CRC is highest in developed countries, reports are indicating a rise in the incidence of early-onset CRC in developing countries. In this study, we aimed to determine the prevalence of CRC among patients hospitalized with lower gastrointestinal complaints at a tertiary health facility in Uganda. Methods: We conducted a 10-year retrospective chart review of patients admitted to Mulago National Referral Hospital in Kampala, Uganda, between 1st January 2010 and 31st December 2020. We reviewed all charts of patients admitted to the lower gastrointestinal tract (GIT) ward. Charts with grossly missing data, pediatric patients, and those from other non-lower GIT specialties were excluded. Results: Data of 1476 unique eligible patients were analyzed. Of these,138 had a diagnosis of CRC (prevalence: 9.3%, 95% confidence interval (95% CI): 6.5-11.7%). Among patients with CRC, the female:male ratio was 1:1. The most common site for CRC was the rectum (59.8%, n= 79). For the 138 participants with CRC, 44 had staging data with 72.8% (n=32) having advanced disease, that is, stage 3 or 4. Factors independently associated with CRC were age ≥50 years (adjusted odds ratio (aOR): 4.3, 95% CI: 2.6-7.1, p < 0.001), female sex (aOR: 1.8, 95% CI: 1.2 −2.8, p = 0.005), being widowed (aOR: 2.5, 95% CI: 1.3-5.0, p = 0.006), and presence of any risk factor for CRC (aOR: 5.3, 95% CI: 2.9-9.9, p < 0.001). Conclusion: CRC is relatively common among patients hospitalized with lower GIT complaints, particularly among women and those with known risk factors for CRC. Awareness creation and screening programs should be instituted to allow early diagnosis of CRC in our setting.

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Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Cited by 8 publications

References 17 publications

The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana

The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana

Survival analysis of young adults from a Brazilian cohort of non-small cell lung cancer patients

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

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