Clinical spectrum of Lyme disease

Garza, Jesús Alberto Cárdenas‐de la; Cruz-Valadez, Estephania De la; Ocampo‐Candiani, Jorge; Welsh, Oliverio

doi:10.1007/s10096-018-3417-1

Cited by 76 publications

(59 citation statements)

References 41 publications

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“…His EM was initially misattributed to cellulitis, leading to a treatment delay of several weeks. EM can appear as a hallmark "bull's-eye" or target-shaped lesion, a uniform red or bluish-red lesion, multiple lesions, or can more rarely have a small, central blister [5,12]. EM can be difficult to recognize when the stereotypical target lesion is absent, or when the lesion is in an area that is difficult to see, as was the case for our patient.…”

Section: Discussionmentioning

confidence: 61%

“…When our patient developed unilateral facial weakness 24 days after his initial illness (Figure 2), he was treated for facial swelling, resulting in a further treatment delay. Neurologic involvement occurs in 12%-14% of Lyme disease cases and as many as half of these are cases of cranial nerve palsy [4,5]. Moreover, Lyme disease is one of the most common causes of seventh nerve palsy in Lyme-endemic regions, where it accounts for up to 25% of facial palsy cases in adults and 34% or more of cases in children [15].…”

Section: Discussionmentioning

confidence: 99%

“…Prognosis is generally very good for patients who receive antibiotic treatment for Lyme disease, especially if treated in the early localized stage [5]. After the treatment, a subset of patients continue to experience symptoms or develop new symptoms of fatigue, cognitive difficulties, or musculoskeletal pain that can persist for more than six months.…”

Section: Introductionmentioning

confidence: 99%

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Lyme Disease with Erythema Migrans and Seventh Nerve Palsy in an African-American Man

Dennison

Novak

Rebman

et al. 2019

Cureus

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lyme Disease with Erythema Migrans and Seventh Nerve Palsy in an African-American Man

Dennison

Novak

Rebman

et al. 2019

Cureus

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“…This may nevertheless reflect the role of strain variation within genospecies [60] and that B. afzelii may be more pathogenic in some areas of Europe. The clinical spectrum of Lyme borreliosis in relation to genospecies [21] and strains is still based on rather few studies. Figure 3.…”

Section: (A) Clinical Symptoms Diagnostics and Treatment Before Dissmentioning

confidence: 99%

Lyme neuroborreliosis and bird populations in northern Europe

et al. 2019

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Many vector-borne diseases are transmitted through complex pathogen–vector–host networks, which makes it challenging to identify the role of specific host groups in disease emergence. Lyme borreliosis in humans is now the most common vector-borne zoonosis in the Northern Hemisphere. The disease is caused by multiple genospecies of Borrelia burgdorferi sensu lato bacteria transmitted by ixodid (hard) ticks, and the major host groups transmit Borrelia genospecies with different pathogenicity, causing variable clinical symptoms in humans. The health impact of a given host group is a function of the number of ticks it infects as well as the pathogenicity of the genospecies it carries. Borrelia afzelii , with mainly small mammals as reservoirs, is the most common pathogen causing Lyme borreliosis, and it is often responsible for the largest proportion of infected host-seeking tick nymphs in Europe. The bird-borne Borrelia garinii , though less prevalent in nymphal ticks, is more likely to cause Lyme neuroborreliosis, but whether B. garinii causes disseminated disease more frequently has not been documented. Based on extensive data of annual disease incidence across Norway from 1995 to 2017, we show here that 69% of disseminated Lyme borreliosis cases were neuroborreliosis, which is three times higher than predicted from the infection prevalence of B. garinii in host-seeking ticks (21%). The population estimate of migratory birds, mainly of thrushes, explained part of the annual variation in cases of neuroborreliosis, with a one-year time lag. We highlight the important role of the genospecies' pathogenicity and the host associations for understanding the epidemiology of disseminated Lyme borreliosis.

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“…Agnė Petrulionienė 1 , Daiva Radzišauskienė 2 , Arvydas Ambrozaitis 2 , Saulius Čaplinskas 3,4 , Algimantas Paulauskas 5 , Algirdas Venalis 1,6 . 1 Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; 2 2 Clinic of Infectious diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; 3 Center for Communicable Diseases and AIDS, Vilnius, Lithuania; 4 Mykolas Romeris University, Vilnius, Lithuania; 5 Vytautas Magnus University, Kaunas, Lithuania; 6 State research Institute Center for Innovative Medicine, Vilnius, Lithuania Background: Lyme disease is a tick born infectious disease caused by different genospecies of Borrelia bacteria (B. burgdorferi sensu strictu, B. afzelii and B. garinii). Disease clinical manifestation varies and belongs on the variety of Borrelia bacteria genospieces.…”

Section: Ab0903 Lyme Arthritis In High Lyme Disease Endemic Europe Zonementioning

confidence: 99%

Ab0902 rheumatic Lyme Disease Symptoms Based on Epidemiological Data in High Endemic Europe Area

Petrulionienė

Radzišauskienė

Ambrozaitis

et al. 2019

Abstracts Accepted for Publication

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BackgroundLyme disease is a tick born infectious disease caused by different genospecies of Borrelia bacteria (B. burgdorferi sensu strictu (ss), B. afzelii and B. garinii). The signs and symptoms of Lyme disease vary, they usually appear in stages, but the stages can overlap. In early stage skin rash (erythema migrans) appears, which may be accompanied by fever, chills, fatigue, body aches, headache, neck stiffness, and swollen lymph nodes. Later signs and symptoms can be these: joint pain and inflammation, neurological problems or other less common syndromes - heart problems, eye inflammation, and liver inflammation. Lyme disease is very common disease in the world, approximately 300,000 people get Lyme disease each year in the United States (Centers for disease control and prevention US), in Lithuania disease frequency is 101.6 cases per 100 000 population (Center for Communicable Diseases and AIDS, Lithuania, 2016 year).ObjectivesTo investigate the frequency of rheumatic symptoms between Lyme diagnosed persons in Lithuania, based on epidemiological data.MethodsWe have analyzed data of Center for Communicable Diseases and Aids of Lithuania about Lyme diagnosed patients from 2014 to 2016 years.ResultsTotal number of cases was 7425. 2791 males, 4633 females, age range 1 - 91 years, median age 52 years. 996 patients found out as symptomatic. The rest were either asymptomatic either information about clinical disease manifestation was not known. Among symptomatic patients two rheumatic symptoms were observed: arthralgia (220 cases, 22,1%), 140 females, 80 males, age range 12 – 84 years, median age 58 years, and myalgia (78 cases, 7,8%), 44 females, 34 males, age range 15-80, median age 56. Other symptoms were erythema migrans (75.6%), headache (15.2%), general weakness (12.4%), fever (10, 1%), and head dizziness (6.4%).ConclusionIn total, almost 30 percentages (29, 91%) of symptoms were rheumatic. To conclude, joint pain and/or muscle pain can lead not only to systemic rheumatic diseases, but to infection diseases as well (for example: Lyme disease).References[1] Sergamumo užkrečiamomis ligomis Lietuvoje apžvalga 2016. Užkrečiamų ligų ir AIDS centras. 96-98 pages. http://www.ulac.lt/uploads/downloads/leidiniai/Sergamumo_apzvalga_2016.pdf[2] Franc Strle, Gary P. Wormser, Linden T. Hu, John A. Branda, Joppe W. R. Hovius, Xin Li, and Paul S. Mead. Lyme borreliosis. Nat Rev Dis Primers. 2017 Aug 3;3:17062. doi: 10.1038/nrdp.2017.62.[3] Lyme disease: summary of NICE guidance. BMJ2018;361:k1261.[4] Clinical spectrum of Lyme disease. Cardenas-de la Garza, J.A., De la Cruz-Valadez, E., Ocampo-Candiani, J. et al. Eur J Clin Microbiol Infect Dis (2018). https://doi.org/10.1007/s10096-018-3417-1Disclosure of InterestsNone declared

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Clinical spectrum of Lyme disease

Cited by 76 publications

References 41 publications

Lyme Disease with Erythema Migrans and Seventh Nerve Palsy in an African-American Man

Lyme Disease with Erythema Migrans and Seventh Nerve Palsy in an African-American Man

Lyme neuroborreliosis and bird populations in northern Europe

Ab0902 rheumatic Lyme Disease Symptoms Based on Epidemiological Data in High Endemic Europe Area

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