Clinical Significance of VEGF-A and Microvessel Density in Diffuse Large B-Cell Lymphoma and Low-Grade Follicular Lymphoma

Shahini, Labinot; Gašparov, Slavko; Petruševska, Gordana; Kerliu, Suzana Manxhuka; Veselaj, Fahredin; Kurshumliu, Fisnik; Kavaja, Floren

doi:10.20471/acc.2017.56.04.02

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…In contrast to most other B-NHL malignancies in which high levels of pro-angiogenic factors and an increased MVD is associated with an adverse prognosis, high level FL vascularization correlates with a beneficial disease course ( 260 – 262 ). The improved clinical outcome apparently correlated with the increased vascularization, but was surprisingly independent of follicular VEGF-A expression ( 223 , 263 ). Some studies stated a minor vascular remodeling in FL compared to reactive LN or follicular hyperplasia, or even vascular regression constraining the growth of reactive and neoplastic follicles ( 260 , 264 ).…”

Section: B Cell Lymphoma-induced Vascular Changes Are Dependent On Thmentioning

confidence: 99%

Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth

2020

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Tumor-induced remodeling of the microenvironment in lymph nodes (LNs) includes the formation of blood vessels, which goes beyond the regulation of metabolism, and shaping a survival niche for tumor cells. In contrast to solid tumors, which primarily rely on neo-angiogenesis, hematopoietic malignancies usually grow within pre-vascularized autochthonous niches in secondary lymphatic organs or the bone marrow. The mechanisms of vascular remodeling in expanding LNs during infection-induced responses have been studied in more detail; in contrast, insights into the conditions of lymphoma growth and lodging remain enigmatic. Based on previous murine studies and clinical trials in human, we conclude that there is not a universal LN-specific angiogenic program applicable. Instead, signaling pathways that are tightly connected to autochthonous and infiltrating cell types contribute variably to LN vascular expansion. Inflammation related angiogenesis within LNs relies on dendritic cell derived pro-inflammatory cytokines stimulating vascular endothelial growth factor-A (VEGF-A) expression in fibroblastic reticular cells, which in turn triggers vessel growth. In high-grade B cell lymphoma, angiogenesis correlates with poor prognosis. Lymphoma cells immigrate and grow in LNs and provide pro-angiogenic growth factors themselves. In contrast to infectious stimuli that impact on LN vasculature, they do not trigger the typical inflammatory and hypoxia-related stroma-remodeling cascade. Blood vessels in LNs are unique in selective recruitment of lymphocytes via high endothelial venules (HEVs). The dissemination routes of neoplastic lymphocytes are usually disease stage dependent. Early seeding via the blood stream requires the expression of the homeostatic chemokine receptor CCR7 and of L-selectin, both cooperate to facilitate transmigration of tumor and also of protective tumor-reactive lymphocytes via HEV structures. In this view, the HEV route is not only relevant for lymphoma cell homing, but also for a continuous immunosurveillance. We envision that HEV functional and structural alterations during lymphomagenesis are not only key to vascular remodeling, but also impact on tumor cell accessibility when targeted by T cell–mediated immunotherapies.

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Section: B Cell Lymphoma-induced Vascular Changes Are Dependent On Thmentioning

confidence: 99%

Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth

2020

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“…The right diagnosis in these cases are often post-operative. It is very difficult, especially in adults, to make a distinction between BL and diffuse large B-cell lymphoma: doubtful cases should undergo genetic testing and additional analysis because the two diseases are treated differently [ [20] , [21] , [22] ].…”

Section: Discussionmentioning

confidence: 99%

Primary ovarian Burkitt's lymphoma presentation in a young woman: A case report

Sergi

Marchese

Botrugno

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Burkitt's lymphoma is one of the fastest growing human cancers and it needs a rapid diagnosis. Case presentation A young woman presented to our institution with acute abdominal pain, tenderness and constipation. Ultrasound reported a right ovarian mass; at laparoscopy, we discovered ascites, peritoneal carcinomatosis and a voluminous pelvic mass. Clinical discussion Diagnosis was confirmed as non-Hodgkin sporadic Burkitt's lymphoma: the careful workup was the key to initiate multiagent chemotherapy. Conclusion Primary ovarian Burkitt's lymphoma, in a young woman in a non-endemic zone, is a rarity that represents a strong diagnostic challenge, but rapid identification can lead the patient to appropriate therapies and improvement of prognosis.

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“…The main challenge in diagnosing BL is distinction between BL and diffuse large B-cell lymphoma, which is difficult. Distinguishing between these two lymphomas, however, is critical, especially in adults, as the two diseases are treated differently ( 3 , 13 , 14 ). Our second case report serves to stress the problem with distinction between the two types of lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma in Gastrointestinal Tract: a Report of Two Cases

Čubranić

Golčić

Fučkar-Čupić

et al. 2019

ACC

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SUMMARYBurkitt lymphoma, a type of non-Hodgkin B-cell lymphoma, is the fastest growing human cancer, presenting pathologically with a ‘starry sky’ pattern. It is most often found in the abdomen and the jaw, however, localization in the abdomen other than the ileocecal area is very rare and described only in a handful of cases. Standard treatment consists of initial tumor cytoreduction followed by intense chemotherapy. Most of the relapses occur within one year of the diagnosis, while the 5-year survival is around 80%. We present two cases which are specific for unusual location of Burkitt lymphoma in the colon and stomach, in immunocompetent patients with negative Epstein-Barr virus tests. Also, one of the patients presented is one of the oldest ever reported with abdominal Burkitt lymphoma, while the other patient is an example of diagnostic difficulties in distinguishing Burkitt lymphoma from similar lymphomas. Due to the rapidly growing tumors and urgent need for cytoreductive surgery, it is crucial to consider the diagnosis of Burkitt lymphoma even in atypical localizations or absence of the common risk factors associated with Burkitt lymphoma.

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Clinical Significance of VEGF-A and Microvessel Density in Diffuse Large B-Cell Lymphoma and Low-Grade Follicular Lymphoma

Cited by 7 publications

References 26 publications

Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth

Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth

Primary ovarian Burkitt's lymphoma presentation in a young woman: A case report

Burkitt Lymphoma in Gastrointestinal Tract: a Report of Two Cases

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