“…When only intraepithelial CD8 cells are studied, the results are more heterogeneous, with one study having a positive effect on OS [ 24 ], two studies having a positive effect on DFS [ 87 , 93 ], three studies without a significant impact [ 39 , 94 , 95 ], and three studies having a negative effect on survival [ 82 , 96 , 97 ]. The results for TREG also vary, with either studies showing a negative impact on OS and DFS [ 45 , 78 , 90 , 94 ], or finding no impact or [ 49 , 79 , 82 ] even a positive impact [ 45 , 98 ].…”