Clinical Significance of the Deeper Anatomic Changes in Lymphoid Diseases

The liver in Hodgkin's disease

“…In the present series, hepatic involvement with Hodgkin's disease appeared to be part of the generalized process, as has been previously maintained (Craver, 1957;Hoster et al, 1948), and in no instance was Hodgkin's disease limited to the liver alone, as reported in a few cases (Goia, 1935;Symmers, 1944). Extrahepatic biliary pathology due to Hodgkin's disease was more frequent in cases with associated liver involvement (P=0.05), suggesting that the portal areas provide a preferred channel for direct dissemination of the process.…”

“…In succeeding years, many cases of Hodgkin's disease with pathologically proven liver involvement were recorded by different authors (Barie, 1875;Barron, 1926;Beatty, 1954;Brauneck, 1889;Coronini, 1928;Chevallier and Bernard, 1932;Craver, 1957;Fabian, 191 1;Foulon, 1932;Hartfall, 1932;Gall, 1956;Jackson and Parker, 1947;Newman and Pushkin, 1951;Klein, 1955; 'This study was financed by a grant from the Lloyd F. Craver Fund of the Memorial Center for Cancer and Allied Diseases, New York City, New York. "Present address: Massachusets Memorial Hospital, Boston, Mass., U.S.A. Murchison, 1869;Reed, 1902;Rolleston, 1912;Sternberg, 1936;Symmers, 1944;Wilks, 1865). Liver involvement in Hodgkin's disease was discussed in papers by Fabian (1911), Longcope (1903), Ziegler (1911), Chevallier and Bernard (1932), Sternberg (1936), Wallhauser (1933), Jackson and Parker (1947), and others (Ackerman and del Regato, 1954;Baker and Mann, 1939;Burnam, 1926;Goldman, 1940;Hoster, Dratman, Craver, and Rolnick, 1948;Symmers, 1944;Uddstromer, 1934;Terplan and Mittelbach, 1929), and was more specifically dealt with in papers by Coronini (1928) and later by Gruber (1930), <...>…”

“…"Present address: Massachusets Memorial Hospital, Boston, Mass., U.S.A. Murchison, 1869;Reed, 1902;Rolleston, 1912;Sternberg, 1936;Symmers, 1944;Wilks, 1865). Liver involvement in Hodgkin's disease was discussed in papers by Fabian (1911), Longcope (1903), Ziegler (1911), Chevallier and Bernard (1932), Sternberg (1936), Wallhauser (1933), Jackson and Parker (1947), and others (Ackerman and del Regato, 1954;Baker and Mann, 1939;Burnam, 1926;Goldman, 1940;Hoster, Dratman, Craver, and Rolnick, 1948;Symmers, 1944;Uddstromer, 1934;Terplan and Mittelbach, 1929), and was more specifically dealt with in papers by Coronini (1928) and later by Gruber (1930), Foulon (1932), Abbatucci and Beatty (1953), and Beatty (1954).…”

“…Students of the problem describe Hodgkin's disease involving the liver at necropsy in from 10 to 60% of the cases (Table I) (Ackerman and del Regato, 1954;Jackson and Parker, 1947;Stemnberg, 1936;Symmers, 1944;Wallhauser, 1933;Ziegler, 1911). Hepatomegaly was observed clinically in from 2.3 to 60% of another series of collected cases (Table I) (Baker and Mann, 1939;Burnam, 1926;Goldman, 1940;Murray, 1908;Uddstrbmer, 1934).…”

“…In Hodgkin's granuloma one encounters focal circumscribed lesions or yellow streaks along the course of the portal areas (Jackson and Parker, 1947), and when extensive fibrosis is present the lesions may resemble gummas (Jackson and Parker, 1947). The hepatic parenchyma surrounding the large lesions may become atrophic (Sherlock, 1955;Symmers, 1944) or may be completely destroyed. In Hodgkin's sarcoma grayish nodules are seen scattered throughout the liver.…”