The liver in Hodgkin's disease

Levitan, Ruven; Diamond, Henry D.; Craver, Lloyd F.

doi:10.1136/gut.2.1.60

Cited by 48 publications

(15 citation statements)

References 18 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A primary HML has been reported to be a very rare malignancy, representing 0.41-1% of extra-nodal lymphomas [14][15][16] . On the contrary, it is well known that ML shows frequent invasion, as it has been reported in approximately 50-60% of autopsy cases with that tumor [16,17] . Secondary HML has been reported to often progress from ML and the diffuse invasive type is most frequent [18] .…”

Section: Discussionmentioning

confidence: 88%

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Kitahata

Hiraoka²,

Kudo³

et al. 2017

Dig Dis

View full text Add to dashboard Cite

Aim/Background: Evaluations of abdominal ultrasonography (US) findings of primary and secondary tumor-forming hepatic malignant lymphoma (HML) have not been adequately reported. In this study, we elucidated US and contrast-enhanced US (CEUS) findings in patients with HML. Materials/Methods: From January 2006 to March 2017, 25 patients with HML were enrolled (primary 7, secondary 18), each of whom was diagnosed pathologically. They were divided into 2 groups based on tumor diameter (cutoff, 30 mm). US imaging findings were retrospectively analyzed. Results: All tumors in patients with a small HML (<30 mm in diameter, small group, n = 14) were revealed as homogeneous hypo-echoic type (100%), with penetrating sign observed in only 1 patient. Tumors in 11 patients in the small group, examined with CEUS, showed homogeneous enhancement in the early vascular phase (91%) and a washout pattern in the portal phase (100%), and they were revealed as defective in the post-vascular phase (100%). In the large group (≥30 mm; n = 11), tumors were revealed as a heterogeneous hypo-echoic lesion in 10 (91%) and penetrating sign was observed in 8 (73%). Dilatation of the distal intrahepatic bile duct by the tumor was observed in 4 patients in the large group. In 7 large group patients examined with CEUS, imaging findings in the early vascular phase varied, with 5 (71%) showing a washout pattern in the portal phase and 5 (71%) revealed as defective in the post-vascular phase. Conclusion: We found that US imaging features of HML differ depending on the tumor diameter.

show abstract

Section: Discussionmentioning

confidence: 88%

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Kitahata

Hiraoka²,

Kudo³

et al. 2017

Dig Dis

View full text Add to dashboard Cite

show abstract

“…Liver involvement is not a rare condition during the advanced stages of Hodgkin's or non-Hodgkin's lymphoma and can be detected at autopsy in 50-80% [2,3,6]. Pathologically, the most common type of intrahepatic involvement of lymphomatous disease is a diffuse distribution of lymphoma throughout the liver parenchyma.…”

Section: Discussionmentioning

confidence: 95%

“…In patients with malignant lymphoma, hepatomegaly is not a specific finding of liver involvement since only 57% of patients with hepatomegaly have histologically proven liver involvement [2]. On the other hand, hepatomegaly is not a sensitive criterion since diffuse liver involvement may exist even though the liver is of normal size [3]. This is confirmed by our study in which hepatomegaly was found in 26 of the 59 patients with secondary lymphomatous involvement of the liver not infected by HIV, giving a sensitivity of 44%.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Hodgkin's and non-Hodgkin's hepatic lymphoma: Sonographic findings

et al. 1993

View full text Add to dashboard Cite

The sonographic studies of 72 patients with pathologically proven Hodgkin's or non-Hodgkin's hepatic lymphoma were retrospectively reviewed. Sixty-eight patients (94%) had secondary hepatic lymphoma (nine of them had AIDS-related lymphoma) and four patients (6%) had primary lymphoma of the liver. Forty-six of 72 patients (64%) had diffuse hepatic involvement, and 26 of 72 patients (36%) had focal liver lesions as demonstrated by sonography. Four patterns of disease were identified: (a) hepatomegaly was depicted by sonography in 26 of the 59 patients with secondary hepatic lymphoma not related to AIDS, in two of the nine patients with AIDS-related secondary hepatic lymphoma, and in one of the four patients with primary hepatic lymphoma; (b) multiple rounded well-delineated hypoechoic liver lesions were found in 22 of the 68 patients with secondary hepatic lymphoma; (c) a large heterogeneous echoic mass, which was an evocating clue to the diagnosis of primary lymphoma of the liver, was found in the four patients with primary lymphoma of the liver; and (d) an absence of sonographic abnormalities was found in 20 of the 59 patients with secondary lymphoma not related to AIDS. Liver involvement with lymphoma should be considered in any patient who develops multiple homogeneous hypoechoic liver masses, even in the absence of known underlying lymphomatous disease.

show abstract

“…Routine laboratory liver function tests have usually been of little help in the diagnosis of lymphomatous involvement of the liver (Sherlock, 1955). Levitan (1969) analyzed one hundred and twelve necropsied cases of Hodgkin's Disease with clinical or laboratory evidence of liver disease during life, or both, and showed that seventy-four or 66% revealed Hodgkin's Disease involving the liver and thirty-eight or 34% exhibited other pathology in the liver. Liver biopsy is the most helpful procedure in establishing the presence of hepatic Hodgkin's Disease.…”

Section: Discussionmentioning

confidence: 99%

Laparotomy and splenectomy in Hodgkin's disease—diagnostic, preventive and therapeutic

Rege

Soderberg

Resnevic

et al. 1972

Journal of Surgical Oncology

View full text Add to dashboard Cite

Thirty primarily unselected but a mixed population of ‘virgin’ and treated patients with a diagnosis of Hodgkin's Disease were subjected to diagnostic laparotomy, splenectomy, liver biopsy, and para‐aortic lymph node biopsy as part of their evaluation for the purpose of staging the disease. The post‐operative pathologic findings were correlated with the preoperative clinical evaluation. Preoperative evaluation of abdominal lymph nodes, spleen, and liver was inaccurate in 3/25 (12%), 9/30 (30%), and 5/30 (17%) patients, respectively, with the result that there was a change in the post‐operative staging in eleven (37%) patients. No instance of liver involvement by Hodgkin's Disease was noted without concomitant splenic involvement. Also, there was no instance of splenic involvement without a concomitant para‐aortic lymph node involvement. These findings suggest a possible spread of the disease to the spleen via the abdominal lymph nodes and to the liver via the spleen. It is concluded that laparotomy with splenectomy is a valuable procedure for diagnostic delineation of intra‐abdominal disease but in addition has therapeutic and preventive implications.

show abstract

The liver in Hodgkin's disease

Cited by 48 publications

References 18 publications

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Hodgkin's and non-Hodgkin's hepatic lymphoma: Sonographic findings

Laparotomy and splenectomy in Hodgkin's disease—diagnostic, preventive and therapeutic

Contact Info

Product

Resources

About