Clinical Significance of Smac and Ki-67 Expression in Pancreatic Cancer

Hu, Haiyan; Liu, Hu; Zhang, Jiawei; Hu, Kai; Yu, Lin

doi:10.5754/hge12071

Cited by 27 publications

(34 citation statements)

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“…Second, the expression levels of Ki-67 and caspase-3 were correlated with the grading of NET. This finding was consistent with that of previous studies showing that the expression levels of Ki-67 and caspase-3 were correlated with the occurrence and development of cancer (Deniz et al, 2015;Hu et al, 2012). Third, the expression levels of Ki-67 decreased and those of caspase-3 increased after everolimus treatment.…”

Section: Discussionsupporting

confidence: 92%

“…However, the molecular mechanism underlying the pathogenesis of NET remains to be further explored. Studies showed that the expression of Ki-67 and caspase-3 was closely correlated with the occurrence and development of breast (Deniz et al, 2015) and pancreatic cancers (Hu et al, 2012). However, the expression profiles and roles of Ki-67 and caspase-3 in NET remains poorly understood.…”

Section: Discussionmentioning

confidence: 99%

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Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

Zhang

Cheng

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki-67 and caspase-3 in NET. Tumor (different developmental stages) and adjacent tissues were collected from patients with NET. The expression of Ki-67 and caspase-3 were detected in 244 paraffin sections of NET using immunohistochemistry. RT-PCR and western blot were used to detect the expression of Ki-67 and caspase-3 at mRNA and protein levels, respectively. The patients (N = 244) were randomly divided into everolimus-intervention and control groups. RT-PCR and western blot were used to measure the expression changes of Ki-67 and caspase-3 before and after everolimus treatment. The rates of Ki-67 expression in NET grades 1-6 were 14.2, 22.1, 37.5, 59.9, 69.9, and 77.8%, respectively. The difference between the groups was significant. The rates of caspase-3 expression in NET grades 1-6 were 28.6, 33.3, 31.3, 60.0, 80.0, and 88.9%, respectively, and the difference between groups was significant. Moreover, the expression of Ki-67 and caspase-3 showed a significant negative correlation. The expression of Ki-67 decreased while that of caspase-3 increased after everolimus treatment. In conclusion, the decrease in Ki-67 expression and increase in caspase-3 expression after everolimus treatment indicated that everolimus exerted its anti-cancer effect by regulating the expression of Ki-67 and caspase-3.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

Zhang

Cheng

et al. 2017

Genet. Mol. Res.

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“…Expression is noted also in phases G 1 , S and M, but no expression is found in phase G 0 [29]. Ki-67 expression correlates with the tumour grade and lymph node metastasis [29]. It has also been stated that the expression of Ki-67 becomes prognostically significant if it exceeds 5% [6,7].…”

Section: Discussionmentioning

confidence: 98%

“…The highest expression of this protein is in G 2 phase of proliferative cells. Expression is noted also in phases G 1 , S and M, but no expression is found in phase G 0 [29]. Ki-67 expression correlates with the tumour grade and lymph node metastasis [29].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors after Curative Resection of Pancreatic Ductal Adenocarcinoma: a Retrospective Study

Štrumfa¹,

Simtniece²,

Āboliņš³

et al. 2012

J Cancer Ther Res

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“…[12,13] Ki67 was significantly more highly expressed in malignant than in normal tissues. [14,15] The nuclear proliferative antigen Ki67 is identified to correlate with the prognosis of the patients to predict the outcome and distant metastasis of sarcoma patients. A significant correlation has been reported between Ki67 expression and mitotic rate in sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Significance of Ki-67 in prognostication of soft tissue tumors

Vijayasankar

Muralitharan

Thanka

2017

APALM

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Background: Histological grading is the most important prognostic factors and the best indicator of metastatic risk in adult soft tissue sarcomas. It has been shown that Ki67 immunohistochemical (IHC) staining is an effective method of assessing the prognosis in a number of tumor types. Ki67 is a cell cycle antigen which is elevated in proliferation states. High level of Ki67 expression is an independent prognostic indicator that correlates with poor outcome in patients with sarcomas. Methods:In this study 53 cases of soft tissue tumor were selected and were classified according to FNCLCC system. IHC staining of Ki-67 was done in all the 53 samples. Diagnosis was made mainly based on histopathological pattern analysis and with the use of IHC.Results: By using FNCLCC grading soft tissue tumor cases were graded as grade I, II and III. The correlation between the FNCLCC grading and Ki67 was done and it was observed that there was statistically significant positive correlation between Ki67 and the grade of the tumor, as evidenced by P-values of 0.002, 0.005 and 0.004. The correlation between the FNCLCC grading and Ki67 index was also assessed. Statistically significant positive correlation between Ki67 index and the grade of the tumor was observed. Conclusion:There was significant correlation noted between FNCLCC grading and Ki-67 index. Thus it can be recommended that Ki-67 IHC stain should be done on routine basis to accurately grade the sarcomas so that it will be beneficial for the management of the patient.

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Clinical Significance of Smac and Ki-67 Expression in Pancreatic Cancer

Abstract: The higher expression of Smac and Ki-67 appear to play a role in the pathogenesis of pancreatic cancer. Combined detection of these proteins may improve the prognostic evaluation of this disease.

Cited by 27 publications

References 0 publications

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

Prognostic Factors after Curative Resection of Pancreatic Ductal Adenocarcinoma: a Retrospective Study

Significance of Ki-67 in prognostication of soft tissue tumors

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