Clinical significance of serum <i>Wisteria floribunda</i> agglutinin positive Mac‐2‐binding protein level and high‐sensitivity C‐reactive protein concentration in autoimmune hepatitis

Nishikawa, Hiroki; Enomoto, Hirayuki; Iwata, Yoshinori; Hasegawa, Kunihiro; Nakano, Chikage; Takata, Ryo; Nishimura, Takashi; Yoh, Kazunori; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Takashima, Tomoyuki; Iijima, Hiroko; Nishiguchi, Shuhei

doi:10.1111/hepr.12596

Cited by 76 publications

(88 citation statements)

References 35 publications

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“…The range of the M2BPGi serum thresholds observed in chronic hepatitis C patientswas different from those described in primary biliary cirrhosis (PBC) or non-alcoholic fatty liver disease [14, 33], typeIautoimmune hepatitis [34], and hepatitis B (Matsumoto and Umemura, personal communications). This difference might be contributed to the difference in patients’ ethnicity or due to the fact that the majority of our cohort was asymptomatic and exhibited mild fibrosis.…”

Section: Discussionmentioning

confidence: 86%

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Kong

Liu

et al. 2017

BMC Gastroenterol

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BackgroundMac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis stages in Chinese patients with chronic hepatitis C infection.MethodsSerum M2BPGi levels were evaluated in 680 patients with chronic hepatitis C and 164 healthy controls who underwent the Fibro Scan® test of liver fibrosis. The diagnostic accuracy of serum M2BPGi values was compared to that of other fibrosis markers, including Fibro Scan®, the aspartate transaminase to platelet ratio index (APRI), the fibrosis index based on four factors (FIB4), and the gamma-glutamyltranspeptidase to platelet ratio (GPR).ResultsAmong the chronic hepatitis C patients, the median serum M2BPGi level increased with increasing fibrosis score as follows: 0.88 (≤F2), 1.70 (F2/F3), and 5.68 (cirrhosis). M2BPGi concentrations could also distinguish between healthy controls (0.38 ± 0.24) and hepatitis C patients (1.57 ± 2.28). After adjusting for potential confounders, M2BPGi was the most significant factor associated with the liver stiffness measurement (effect size = 0.275, P < 0.001). The optimum cutoff values of serum M2BPGi for patients with F2 and F4 were 0.945 and 1.355, respectively. The area under the curve of serum M2BPGi for prediction of significant fibrosis (F ≥ 4) using was comparable to that of APRI (0.892 vs. 0.873), while it was superior to that of other alternative markers, including FIB4 (0.818) and GPR (0.851). Compared with other non-invasive markers, M2BPGi had the greatest specificity for diagnosing cirrhosis and cirrhosis in hepatitis C patients.ConclusionsOur results suggest that the level of serum M2BPGi would be a simple and reliable diagnostic tool for identifying liver fibrosis stage in Chinese patients with chronic hepatitis.

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Section: Discussionmentioning

confidence: 86%

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Kong

Liu

et al. 2017

BMC Gastroenterol

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“…Recent studies also showed that WFA + ‐M2BP can be helpful for clinical outcome in HCC patients treated with surgical resection or in CHC patients treated with antiviral therapy . In addition, in our previous studies, we showed that WFA + ‐M2BP can be helpful for predicting the degree of liver fibrosis in patients with autoimmune hepatitis and primary biliary cirrhosis …”

Section: Introductionmentioning

confidence: 80%

Proposal of a predictive model for advanced fibrosis containing Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein in chronic hepatitis C

Nishikawa

Takata

Enomoto

et al. 2016

Hepatology Research

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Aim:We aimed to construct a predictive model for advanced fibrosis containing Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA + -M2BP) level in patients with chronic hepatitis C (CHC) and to validate its accuracy in an independent cohort.Methods: A total of 386 patients with CHC were retrospectively analyzed. For the purpose of this study, we formed a training set (n = 210) and a validation set (n = 176). In the training set, we investigated variables linked to the presence of advanced fibrosis using univariate and multivariate analyses. We constructed a formula for predicting advanced fibrosis and validated its accuracy in the validation cohort. Receiver operating characteristic curve (ROC) analysis was carried out for calculating the area under the ROC (AUROC).Results: In multivariate analyses, WFA + -M2BP (P = 0.029) and prothrombin time (PT) (P = 0.018) were found to be significant predictive factors linked to the presence of advanced fibrosis; platelet count (P = 0.098) and hyaluronic acid (P = 0.078) showed borderline statistical significance for the presence of advanced fibrosis. Using these four variables (with the initials MPPH), we constructed the following formula: MPPH score = À3.584 À (0.275 × WFA + -M2BP) + (0.068 × platelet count) + (0.042 × PT) À (0.005 × hyaluronic acid). In the training and validation sets, MPPH score yielded the highest AUROCs (0.87 and 0.83) for predicting advanced fibrosis among eight serum liver fibrosis markers. Similarly, in the training and validation sets, MPPH score had the highest diagnostic accuracies for predicting advanced fibrosis among eight serum variables (81.4% and 74.4%). Conclusion:Our proposed MPPH scoring system can be useful for predicting advanced fibrosis in patients with CHC.

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“…It is interesting that patients with AIH had higher WFA + ‐M2BP concentrations than those with PSC alone. The presence of liver inflammation can cause higher WFA + ‐M2BP titers . Additionally, the multivariate analysis of this study shows that autoimmune hepatitis is only one significant predictor for the late histological group in PSC.…”

Section: Discussionmentioning

confidence: 58%

Usefulness of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein in children with primary sclerosing cholangitis

Umetsu¹,

Inui²,

Sogo³

et al. 2017

Hepatology Research

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Clinical significance of serum Wisteria floribunda agglutinin positive Mac‐2‐binding protein level and high‐sensitivity C‐reactive protein concentration in autoimmune hepatitis

Abstract: WFA(+) -M2BP can be a useful marker for assessing liver histological findings in AIH patients and it correlated well with hCRP concentration.

Cited by 76 publications

References 35 publications

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Proposal of a predictive model for advanced fibrosis containing Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein in chronic hepatitis C

Usefulness of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein in children with primary sclerosing cholangitis

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