Clinical Significance of Serum Albumin/Globulin Ratio in Patients With Pyogenic Liver Abscess

Abstract

Pyogenic liver abscess (PLA) remains a significant challenge for modern clinicians. Serum albumin/globulin ratio (AGR) can reflect the progress of many diseases. However, the clinical significance of AGR in PLA has not been evaluated. The aim of this study was to explore the effect of AGR on the clinical characteristic and prognosis in PLA patients. This retrospective study included 392 PLA patients who admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January, 2007 to December, 2016. The medical records on admission were collected. Compared with the healthy controls and the patients with extraperitoneal infection or non-infectious liver disease, PLA patients had lower levels of AGR. The mean level of AGR in PLA patients was 1.02 ± 0.25. There were 179 (45.4%) patients with AGR > 1.02 and 213 (54.6%) patients with AGR ≤ 1.02. The baseline data and treatment plans of PLA patients with high or low AGR were comparative. However, PLA patients with a low AGR had higher body temperature, leukocytes and neutrophils, lower hemoglobin, poorer liver and coagulation function, larger abscess diameter, higher positive rate of pus culture and proportion of Escherichia coli, and were more susceptible to multiple bacteria. Moreover, PLA patients with a low AGR had more complications, including systemic inflammatory response syndrome (SIRS), peritoneal effusion and pleural effusion. And it also needs longer time for temperature normalization and hospital stay. In conclusion, PLA patients have lower AGR and lower AGR is associated with worse clinical manifestations, more complications and poorer prognosis. Thus, monitoring of AGR is of great clinical significance for evaluating the progress of PLA patients.

AMELIORATIVE POTENTIAL OF Moringa oleifera LEAF EXTRACT AGAINST ARSENIC TOXICITY IN Labeo rohita

“…In the current investigation, we found that arsenic-exposed fish had low levels of total protein, albumin, and globulin, which may have been caused by proteolysis, a failure in protein synthesis brought on by hepatic and renal dysfunction (Ellis et al, 1981). In arsenic-exposed fish, low level of albumin may represent low blood viscosity, whereas low levels of globulin may be due to the liver inability to synthesized sufficient globulin, an indication of weakened immunity (Zhang et al, 2021). These results are in agreement with those that have been observed after toxicant exposure in several fish species (Kannan et al, 2014;Singh et al, 2015;Ghaffar et al, 2017;Majumder and Kaviraj, 2017;Kumar et al, 2019).…”

Platelet-to-White Blood Cell Ratio: A Feasible Biomarker for Pyogenic Liver Abscess

“…In addition, pleural effusion, which develops in approximately 20-50% of patients with PLA, causes considerable distress to patients during treatment [ 31 , 32 , 33 , 34 , 35 ]. The pathophysiology of the development of pleural effusion in patients with PLA is known to result from inflammation of the diaphragm and increased permeability of the lymphatics [ 36 ].…”

Accuracy of Albumin, Globulin, and Albumin–Globulin Ratio for Diagnosing Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis

“…Therefore, serum screening tests that can detect physical responses to infection may improve the preoperative diagnostic accuracy of PJI. In various medical fields, serum albumin (Alb) is used as a nutritional indicator and predictive marker for cancer prognosis and infectious diseases [11][12][13]. Recently, the quantitative evaluation of serum Alb and globulin (Glb) levels and the Alb-Glb ratio (AGR) have been reported to be useful in the diagnosis of PJI.…”