Platelet-to-White Blood Cell Ratio: A Feasible Biomarker for Pyogenic Liver Abscess

Ko, Dong Gyun; Park, Ji-Won; Kim, Jung Hee; Jung, Jang-Han; Kim, Hyoung-Su; Suk, Ki Tae; Jang, Myoung-Kuk; Park, Sang Hoon; Lee, Myung-Seok; Kim, Dong Joon; Kim, Sung-Eun

doi:10.3390/diagnostics12102556

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…Šis paprastas ir ekonomiškas žymuo atskleidė, jog asmenims, kurie serga PKA ir turi žemesnį nei 17,05 TLS, žymiai dažniau pasireiškia tokios komplikacijos kaip metastazinės infekcijos, skysčio susikaupimas pleuros ertmėje, pailgėja hospitalizacijos laikas. Reguliarus TLS stebėjimas gali padėti anksčiau nustatyti komplikacijas ir pagerinti prognozę [6].…”

Section: Rezultatų Aptarimasunclassified

Piogeninis Kepenų Abscesas: Klinikinis Atvejis

Lubys,

Jakovlevaitė,

Bružienė

2024

Health Sciences

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Įvairiais klinikiniais simptomais pasireiškiantys kepenų abscesai dažnai supainiojami su labiau paplitusiomis infekcijomis. Svarbu laiku nustatyti diagnozę, kad būtų išvengta galimų sunkių komplikacijų. Šiame straipsnyje analizuojamas piogeninio kepenų absceso atvejis, atskleidžiama ligos eiga, diagnostikos metodai ir taikomos terapinės intervencijos. Aptariami klinikiniai, laboratoriniai ir radiologiniai kepenų absceso požymiai, galimos komplikacijos ir gydymo metodai.

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Section: Rezultatų Aptarimasunclassified

Piogeninis Kepenų Abscesas: Klinikinis Atvejis

Lubys,

Jakovlevaitė,

Bružienė

2024

Health Sciences

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“…The platelet-to-white blood cell ratio (PWR), a potential biomarker of vascular inflammation predicting acute ischemic stroke and cardiovascular risk [27,28], has never been assessed in relation to psoriasis. Moreover, the usefulness of PWR in hepatic diseases has been, until now, tested only in acute-to-chronic liver failure (ACLF) [29], HBV-positive patients [30], and pyogenic liver abscesses [31].…”

Section: Introductionmentioning

confidence: 99%

Predictive Performances of Blood-Count-Derived Inflammatory Markers for Liver Fibrosis Severity in Psoriasis Vulgaris

Tiucă,

Morariu,

Mariean

et al. 2023

IJMS

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Psoriasis is an immune-mediated, chronic disorder that significantly alters patients’ quality of life and predisposes them to a higher risk of comorbidities, including liver fibrosis. Various non-invasive tests (NITs) have been validated to assess liver fibrosis severity, while blood-count-derived inflammatory markers have been proven to be reliable in reflecting inflammatory status in psoriatic disease. The fibrosis-4 (FIB-4) index became part of the newest guideline for monitoring psoriasis patients undergoing systemic treatment. Patients with psoriasis vulgaris and fulfilling inclusion criteria were enrolled in this study, aiming to assess for the first time in the literature whether such inflammatory markers are useful in predicting liver fibrosis. Based on internationally validated FIB-4 index values, patients were divided into two study groups: a low risk of significant fibrosis (LR-SF) and a high risk of significant fibrosis (HR-SF). Patients from HR-SF were significantly older and had higher values of the monocyte-to-lymphocyte ratio (MLR) (p < 0.001), which further significantly correlated with fibrosis severity (p < 0.001). Platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), platelet-to-white blood cell ratio (PWR), and aggregate index of systemic inflammations (AISI) significantly correlated negatively with liver fibrosis (p < 0.001). PWR proved to be the most reliable inflammatory predictor of fibrosis severity (AUC = 0.657). MLR, PWR, and AISI were independent inflammatory markers in multivariate analysis (p < 0.001), while the AST to platelet ratio index (APRI) and AST to ALT ratio (AAR) can be used as additional NITs for significant liver fibrosis (p < 0.001). In limited-resources settings, blood-count-derived inflammatory markers such as MLR, PWR, and AISI, respectively, and hepatic indexes APRI and AAR prove to be of particular help in predicting significant liver fibrosis.

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“…It has been reported to be used in predicting short-term postoperative outcomes in patients undergoing renal malignancy surgery [16]. Furthermore, it has been demonstrated to serve as an independent predictor of clinical outcomes in acute promyelocytic leukemia [17], ischemic stroke [18], and pyogenic liver abscesses [19]. Apart from their hemostatic function, platelets can trigger and exacerbate inflammation by interacting with immune cells and secreting pro-inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

The Association between the Platelet to White Blood Cell Ratio and Chronic Kidney Disease in an Aging Population: A Four-Year Follow-Up Study

Xiong,

Zhong,

Zhang

et al. 2023

JCM

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Introduction: The platelet to white blood cell ratio (PWR) has been reported to be a prognostic factor for some diseases, such as subarachnoid hemorrhage. However, the association between the PWR and chronic kidney disease (CKD) remains unknown. To investigate the cross-sectional and longitudinal association between the PWR and CKD, this study was performed. Methods: This study used datasets from a national prospective cohort in China (China Health and Retirement Longitudinal Study). A retrospective cohort from 2011 to 2015 was constructed. The PWR was stratified as a categorical variable according to tertiles (T1–T3 groups). CKD was defined as an estimated glomerular filtration rate < 60 mL min−1/1.73/m2. Univariate and multivariate logistic regressions and restricted cubic spline regression were adopted to assess the linear and non-linear association between the PWR and CKD. Propensity score matching was used to balance the discrepancies between covariates. Subgroup and interactive analyses were performed to explore potential interactive effects of covariates. Missing values were interpolated using random forest. The PWR was also stratified according to the median and quartiles as sensitivity analyses. Results: A total of 8600 participants were included in this study. In the full model, the odds ratios (ORs) of prevalent CKD were 0.78 (95% CI = 0.62–0.97, p < 0.05) for the T2 group and 0.59 (95% CI = 0.46–0.76, p < 0.001) for the T3 group. There were significant interactive effects of marital status and smoking in the PWR–CKD association (both p for interaction < 0.05). An L-shaped, non-linear association was detected between the PWR and prevalent CKD in the overall population, participants ≥ 60 years, and females subgroups (all p for non-linear < 0.05). All sensitivity analyses supported the negative association between the PWR and prevalent CKD. In the 2011–2015 follow-up cohort, the ORs of incident CKD were 0.73 (95% CI = 0.49–1.08, p > 0.05) and 0.31 (95% CI = 0.18–0.51, p < 0.001) for the T2 and T3 groups, respectively, in the full model. Conclusions: A high PWR is associated with a reduced risk of prevalent and incident CKD. The PWR may serve as a predictor for CKD, facilitating the early identification and intervention of kidney function decline.

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Platelet-to-White Blood Cell Ratio: A Feasible Biomarker for Pyogenic Liver Abscess

Cited by 6 publications

References 42 publications

Piogeninis Kepenų Abscesas: Klinikinis Atvejis

Piogeninis Kepenų Abscesas: Klinikinis Atvejis

Predictive Performances of Blood-Count-Derived Inflammatory Markers for Liver Fibrosis Severity in Psoriasis Vulgaris

The Association between the Platelet to White Blood Cell Ratio and Chronic Kidney Disease in an Aging Population: A Four-Year Follow-Up Study

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