Clinical Significance of Preoperative Serum Sialic Acid Levels in Colorectal Cancer: Utility in the Detection of Patients at High Risk of Tumor Recurrence

Feijoo-Carnero, Carmen; Rodrı́guez-Berrocal, Francisco Javier; Cadena, M. Pez de la; Ayude, Daniel; Carlos, Alejandro de; Martínez-Zorzano, Vicenta S.

doi:10.1177/172460080401900105

Cited by 21 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DFS rates obtained in this study for TNM stages I-III were highly similar to the ones obtained for Dukes staging, by others and in previous works of us, although rates of death were a bit lower provided this work has not included patients at TNM stage IV and it is a 5-year survival study [ 24 - 27 ].…”

Section: Discussionsupporting

confidence: 87%

Preoperative serum CA 72.4 as prognostic factor of recurrence and death, especially at TNM stage II, for colorectal cancer

et al. 2013

View full text Add to dashboard Cite

BackgroundNowadays, evaluation of colorectal cancer prognosis and decision-making for treatment continues to be based primarily on TNM tumour stage. Administration of adjuvant chemotherapy is especially challenging for stage II patients that can have very different disease-related outcomes. Therefore, more reliable prognostic markers need to be developed to improve the selection of stage II patients at high risk for recurrence. Our purpose is to assess the prognostic value of preoperative serum CA 72.4 to improve the risk stratification of CRC patients.MethodsPreoperative sera collected from 71 unselected patients between January 1994 and February 1997 was assayed for CA 72.4 and CEA levels. Patients were followed-up for at least 30 months or until relapse. Survival curves were estimated by the Kaplan-Meier method and the prognostic value was determined using Log-Rank test and Cox regression analysis.ResultsPreoperative CA 72.4 levels above 7 U/mL correlate with a worse prognosis, with associated recurrence and death percentages exceeding the displayed by CEA. In a multivariate analysis, its combination with CEA proved the most important independent factor predicting survival. Remarkably, at stage II CA 72.4 also discriminates better than CEA those patients that will relapse or die from those with a favourable prognosis; however, CEA has not a negligible effect on survival.ConclusionsThe most outstanding finding of the present work is the correct classification of nearly every patient with bad prognosis (relapse or death) at TNM stage II when CEA and CA 72.4 are used altogether. This could improve the decision-making involved in the treatment of stage II colon cancer. Certainly further large-scale studies must be performed to determine whether CA 72.4 can be effectively used in the clinical setting.

show abstract

Section: Discussionsupporting

confidence: 87%

Preoperative serum CA 72.4 as prognostic factor of recurrence and death, especially at TNM stage II, for colorectal cancer

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[65][66][67][68]. Lipid-and protein-bound Sia are also elevated in the plasma from cancer patients as compared with healthy individuals [66,[69][70][71][72] and are linked to acute phase condition and chronic disease [e.g.…”

Section: Role Of Neu1 In Regulation Of Receptors and Signalling Pathwaysmentioning

confidence: 99%

Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors

Pshezhetsky

Hinek

2011

Glycoconj J

View full text Add to dashboard Cite

Terminal sialic acid residues are found in abundance in glycan chains of glycoproteins and glycolipids on the surface of all live cells forming an outer layer of the cell originally known as glycocalyx. Their presence affects the molecular properties and structure of glycoconjugates, modifying their function and interactions with other molecules. Consequently, the sialylation state of glycoproteins and glycolipids has been recognized as a critical factor modulating molecular recognitions inside the cell, between the cells, between the cells and the extracellular matrix, and between the cells and certain exogenous pathogens. Sialyltransferases that attach sialic acid residues to the glycan chains in the process of their initial synthesis were thought to be mainly responsible for the creation and maintenance of a temporal and spatial diversity of sialylated moieties. However, the growing evidence also suggests that in mammalian cells, at least equally important roles belong to sialidases/neuraminidases, which are located on the cell surface and in intracellular compartments, and may either initiate the catabolism of sialoglycoconjugates or just cleave their sialic acid residues, and thereby contribute to temporal changes in their structure and functions. The current review summarizes emerging data demonstrating that neuraminidase 1 (NEU1), well known for its lysosomal catabolic function, can be also targeted to the cell surface and assume the previously unrecognized role as a structural and functional modulator of cellular receptors.

show abstract

“…Thus, serum sialic acid (SA) concentration will increase in those tumors over-expressing glycoproteins and glycolipids and can be used as a diagnostic marker of cancer [13,14]. Studies found that serum SA was elevated in patients with colorectal tumor, prostate cancer and ovarian malignancies and approved it could be used as a marker for tumor diagnosis in clinical practice [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Zhang

Li³

et al. 2015

Clinica Chimica Acta

View full text Add to dashboard Cite

Clinical Significance of Preoperative Serum Sialic Acid Levels in Colorectal Cancer: Utility in the Detection of Patients at High Risk of Tumor Recurrence

Cited by 21 publications

References 27 publications

Preoperative serum CA 72.4 as prognostic factor of recurrence and death, especially at TNM stage II, for colorectal cancer

Preoperative serum CA 72.4 as prognostic factor of recurrence and death, especially at TNM stage II, for colorectal cancer

Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Contact Info

Product

Resources

About