Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Li, Peilong; Zhang, Xin; Li, Tong-fu; Wang, Lili; Li, Du; Yang, Yongmei; Li, Juan; Wang, Haiyan; Zhang, Yi; Wang, Chuanxin

doi:10.1016/j.cca.2014.10.026

Cited by 15 publications

(17 citation statements)

References 27 publications

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“…The obtained results confirm the reports claiming that the determination of the level of sialic acids can be used for the diagnosis of LC and ovarian cancer [10,21]. In addition, our studies have shown that this diagnostic approach can be relevant to malignant neoplasms of the body and cervix of the uterus.…”

Section: Resultssupporting

confidence: 90%

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Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

Bel’skaya¹,

Kosenok²,

Массард³

2018

Sovrem Tehnol Med

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The aim of the study was to explore the option of using sialic acid of saliva as a marker for primary and differential diagnosis of lung cancer.Materials and Methods. The study included 1903 subjects divided as follows: the main group (lung cancer, n=337, and nonmalignant lung diseases, n=108), the comparison group (other types of oncological diseases, n=1033), and the control group (generally healthy, n=425). All participants filled the medical questionnaires and presented the histological verification of their diagnoses; then they underwent biochemical examination of their saliva samples. The level of sialic acids and the content of mucin in the saliva were determined spectrophotometrically.Results. We found that the average level of sialic acids in the control group (0.270±0.037 mmol/L) was significantly higher than that in lung cancer (0.138±0.006 mmol/L) or non-tumor diseases of the lungs (0.148±0.003 mmol/L). The saliva content of sialic acids did not significantly differ between various histological types of lung cancer (0.175±0.027 and 0.166±0.024 mmol/L for squamous cell lung cancer and adenocarcinoma, respectively). We also noted that in patients with metastatic lung cancer, the level of sialic acids in the saliva was the lowest as compared with the generally healthy subjects.Conclusion. The level of sialic acids in the saliva decreases both in patients with lung cancer and in patients with non-malignant lung diseases. These results rationalize the option of using this parameter for the primary diagnosis of lung disorders as a whole; however, for the differential diagnosis of various lung diseases, the level of saliva sialic acids is of little value.

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Section: Resultssupporting

confidence: 90%

“…A number of studies demonstrated the feasibility of determining sialic acids for the diagnosis of colorectal cancer [7], thyroid cancer [8], prostate cancer [9], ovary cancer [10], and oral cavity cancer [11]. However, the diagnostic value of sialic acids as a marker of LC was never explored.…”

Section: Introductionmentioning

confidence: 99%

Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

Bel’skaya¹,

Kosenok²,

Массард³

2018

Sovrem Tehnol Med

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“…However, the establishment of RIs for CA125 during pregnancy has been limited because of wider fluctuations . Previous studies have also shown that age, fertility status, menopause, and ethnicity may affect HE4 serum levels . In this state, the ROMA index may be a more ideal tumor marker for pregnant women.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14][15] Previous studies have also shown that age, fertility status, menopause, and ethnicity may affect HE4 serum levels. 11,[16][17][18] In this state, the ROMA index may be a more ideal tumor marker for pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Measurement of HE4 and CA125 and establishment of reference intervals for the ROMA index in the sera of pregnant women

Zheng

Zhang

et al. 2017

Clinical Laboratory Analysis

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“…A literature review suggested that hydroxyproline (ramification of P) could be used as a better diagnosis method and dynamic monitoring of gynecologic pelvic malignancies compared with risk of ovarian malignancy algorithm calculated based on HE4 and CA125. 23 Therefore, we suggested that the identified peptides of this study might be the key regulating factors during the OC development progression.…”

Section: Discussionmentioning

confidence: 73%