Clinical significance of postoperatif controlling nutritional status (CONUT) score in glioblastoma multiforme

Tang

et al. 2022

JCM

Inflammation is related to cancer. The systemic immune-inflammation index (SII) has been linked to the prognosis of many types of cancer. The present study aimed to determine the prognostic value of the SII in glioblastoma (GBM) patients based on meta-analysis and single-center retrospective analysis. Relevant publications published before 1 October 2022 were identified by searching PubMed, EMBASE, Cochrane Library databases, and Web of Science. Moreover, 208 GBM patients from Zhongnan Hospital were incorporated. Kaplan–Meier and Cox regression analyses determined the prognostic significance of inflammatory markers. By combining these indicators, we developed scoring systems. Nomograms were also built by incorporating independent variables. The accuracies of nomograms were evaluated by Harrell’s concordance index (c-index) and the calibration curve. According to meta-analysis, an elevated SII predicted the worst overall survival (OS) (Hazard ratio [HR] = 1.87, p < 0.001). Furthermore, a higher SII (>510.8) (HR = 1.782, p = 0.007) also predicted a poorer outcome in a retrospective cohort. The scoring systems of SII-NLR (neutrophil-to-lymphocyte ratio) showed the best predictive power for OS. The nomogram without MGMT (c-index = 0.843) exhibited a similar accuracy to that with MGMT (c-index = 0.848). A pre-treatment SII is independently associated with OS in GBM. A nomogram integrating the SII-NLR score may facilitate a comprehensive survival evaluation independent of molecular tests in GBM.

Section: Discussionmentioning

confidence: 99%

Section: A Meta-analysis Evaluating the Prognosis Of Sii In Patients ...mentioning

confidence: 99%

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Prognostic Value of Systemic Immune-Inflammation Index (SII) in Patients with Glioblastoma: A Comprehensive Study Based on Meta-Analysis and Retrospective Single-Center Analysis

Tang

et al. 2022

JCM

“…Controlling nutritional status (CONUT) score is also a useful nutritional marker to evaluate nutritional status and predict prognosis in cancer patients, which is similar in composition with NPS ( 21 – 23 ). Recent studies have reported that both preoperative and postoperative CONUT score serve as an independent prognostic indicator for GBM patients ( 24 , 25 ). In the current study, we aim to explore the prognostic value of preoperative NPS in GBM patients and compare the prognostic ability between NPS and CONUT.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Naples prognostic score is a reliable prognostic indicator for newly diagnosed glioblastoma patients

Yuan

et al. 2022

Front. Oncol.

BackgroundGlioblastoma (GBM) accounts for approximately 80% of malignant gliomas and is characterized by considerable cellularity and mitotic activity, vascular proliferation, and necrosis. Naples prognostic score (NPS), based on inflammatory markers and nutritional status, has a prognostic ability in various cancers. In the current study, we aim to explore the prognostic value of operative NPS in GBM patients and compare the prognostic ability between NPS and controlling nutritional status (CONUT).Materials and methodsThe retrospective analysis was carried out on consecutive newly diagnosed GBM patients who had underwent tumor resection at West China Hospital from February 2016 to March 2019. All statistical analyses were conducted using SPSS software and R software.ResultsA total of 276 newly diagnosed GBM patients were enrolled in the current study. Overall survival (OS) (p < 0.001) and tumor location (p = 0.007) were significantly related to NPS. Serum albumin concentrate, cholesterol concentrate, neutrophil-to-lymphocyte ratio, lymphocyte ratio, and CONUT score were all significantly associated with NPS (p < 0.001). The Kaplan–Meier curve indicated that NPS (log-rank test, p < 0.001) and CONUT score (log-rank test, p = 0.023) were significantly associated with OS. Multivariate Cox regression revealed that both NPS and CONUT score served as independent prognostic indicators. The prognostic model with NPS had the strongest prognostic capability and best model-fitting.ConclusionIn the current study, NPS is found as an independent prognostic indicator for patients with newly diagnosed GBM, and the prognostic ability of NPS is superior to CONUT score.

“…Furthermore, most immunosuppressive cells, including M2-TAMs, MDSCs, and Tregs, are recruited by tumor-related in ammation, which may provide more convenience for the construction of the immunosuppressive tumor microenvironment and regulate malignant tumor biological behavior [14][15][16] . The value of peripheral blood in ammatory markers, including the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio 17 , systemic immune-in ammation index 18 , prognostic nutritional index, and postoperative controlling nutritional status 19 , have been evaluated in glioma patients, and those in ammatory markers were associated with the prognosis of glioma patients. The in ammatory microenvironment may indisputably play an important role in the proliferation and progression of glioma.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory expression profiling defines the tumor microenvironment and immunity in lower-grade gliomas

Xiang

et al. 2022

Preprint

Objective: Lower-grade glioma (LGG) arises from glial or precursor cells including the world health organization (WHO) grade glioma, which has a favorable prognosis compared with glioblastomas. However, LGG progression is inevitable due to drug resistance and tumor invasiveness. The inflammatory response has been a well-established hallmark associated with tumor occurrence and recurrence. It is necessary to explore the heterogeneity of the inflammatory response in LGG.Methods: The differential and prognostic inflammatory response-related genes(IRRG) of the cancer genome atlas(TCGA) database were used to perform consensus clustering to identify robust clusters. The Chinese Glioma Genome Atlas(CGGA) database was used to validate this inflammation subtype. The clinical characteristics, immune infiltration, metabolism, and somatic variation of each cluster were assessed. A risk score associated with inflammation was constructed.Results: We successfully observed and validated three distinct inflammatory subtypes in LGG. It is noteworthy that the B subtype has a shorter overall survival than the A and C subtypes. The B subtype had higher immune, stromal, and ESTIMATE scores than the A and C subtypes but lower tumor purity than the A and C subtypes. In addition, immune, stromal, and ESTIMATE scores of the A subtype were higher than the hose of the C subtype, while tumor purity was lower than that of the C subtype. Three inflammation subtypes correlated with diverse metabolic characteristics, drug sensitivity, and somatic alterations. Furthermore, we developed and validated an inflammatory signature with better performance of prognosis prediction.Conclusion: This study identified a new classification of LGG according to inflammatory gene profiling and emphasized inflammatory heterogeneity within LGG.