Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus

Tanimura, Shun; Fujieda, Yuichiro; Kono, Michihiro; Shibata, Yuhei; Hisada, Ryo; Sugawara, Eri; Nakamura, Hiroyuki; Ohmura, Koichiro; Shimamura, Sanae; Mitani, Asako; Shida, Haruki; Watanabe, Toshiyuki; Kato, Masaaki; Oku, Kenji; Bohgaki, Toshiyuki; Amengual, Olga; Yasuda, Shinsuke; Shimizu, Chisato; Atsumi, Tatsuya

doi:10.1080/14397595.2017.1408755

Cited by 15 publications

(10 citation statements)

References 41 publications

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“…Special attention should be directed to baseline levels considered in these conditions, because PSP in RA patients are higher than in healthy controls [20]. Conversely, in other autoimmune diseases such a systemic lupus erythematosus (SLE), PSP correlates with the disease activity of SLE [21]. Therefore, the use of PSP as a bacterial infection biomarker cannot be applied to all autoimmune disease but only to those where PSP is not affected itself by the disease activity.…”

Section: Psp In Autoimmune Diseasementioning

confidence: 99%

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Galliera

Massaccesi

Vecchi

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.

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Section: Psp In Autoimmune Diseasementioning

confidence: 99%

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Galliera

Massaccesi

Vecchi

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…It has been reported that when neutrophils and monocytes phagocytose infectious bacteria in blood vessels, CD14 expressed on their cell surface is taken up by the cells, degraded by neutrophil elastase, and released as presepsin into the blood [14] . However, there are reports of high presepsin levels in patients with SLE without infection, and the cause of this has not been clari ed [18,19] . We focused on NETs, which are known to increase in the blood in sepsis and in SLE patients, to elucidate the production mechanism of increased presepsin even in SLE patients who do not have an infection.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, elevated presepsin levels have been reported in patients with systemic lupus erythematosus (SLE) and hemophagocytic syndrome, autoimmune diseases without evidence of infection, causes of which remain unknown [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Elucidation of a Novel Mechanism of Presepsin Production by Monocyte/macrophage Phagocytosis of Neutrophil Extracellular Traps

Ikegame

Kondo

Kitaguchi

et al. 2022

Preprint

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Presepsin, a biomarker discovered in Japan, has been clinically applied as a diagnostic aid for sepsis. Recently, however, it has been reported that presepsin levels are elevated in patients with severe systemic lupus erythematosus without infection, suggesting the existence of a production mechanism that does not involve bacterial phagocytosis. In this study, we aimed to elucidate the mechanism of presepsin production without bacterial phagocytosis and explore the clinical significance of presepsin. Neutrophil extracellular traps (NETs) were induced by Escherichia coli and phorbol myristate acetate (PMA) in neutrophils isolated from the peripheral blood of healthy subjects. NET induction alone did not increase presepsin levels, but co-culturing with monocytes significantly increased them. The addition of a NET formation inhibitor also suppressed presepsin levels, suggesting that presepsin production is greatly influenced by monocyte phagocytosis of NETs. Phagocytosis of NETs by THP-1 and U937 cells, which was induced by CD14 expression, also increased presepsin levels. This study suggests that presepsin can be used to assess the severity of inflammatory diseases, such as autoimmune diseases, and monitor treatment effects.

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“…S. Tanimura и соавт. [23] определяли ПСП у 35 больных СКВ (в том числе 13 -с инфекциями различной локализации) и 72 -с иными системными РЗ (РА, васкулиты, синдром Шегрена, системная склеродермия и др., включая 40 больных с инфекциями). Отмечено более высокое содержание ПСП при СКВ, РА и васкулитах по сравнению с другими нозологиями, однако различия были статистически не значимы.…”

Section: пресепсинunclassified

Role of biomarkers in the diagnosis of bacterial infections in rheumatic diseases

Белов¹,

Тарасова²,

Муравьева³

2019

Naučno-praktičeskaâ revmatologiâ

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In modern rheumatology, the problem of differential diagnosis of bacterial infection and active rheumatic process still retains its relevance. At the same time, it is very important to search for a biomarker - the gold standard for the diagnosis of an infection in patients with rheumatic diseases (RDs) in order to rapidly determine a treatment policy. This review analyzes the diagnostic significance and possibility of using some laboratory markers for bacterial infections in modern rheumatology. It emphasizes the importance of a multimarker approach that allows increasing the significance of individual parameters in the diagnosis of infections in RD.

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Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus

Abstract: Elevated plasma PSEP levels were correlated with disease activity of SLE, suggesting inappropriate monocyte or neutrophil activation in the pathophysiology of SLE exacerbation.

Cited by 15 publications

References 41 publications

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Elucidation of a Novel Mechanism of Presepsin Production by Monocyte/macrophage Phagocytosis of Neutrophil Extracellular Traps

Role of biomarkers in the diagnosis of bacterial infections in rheumatic diseases

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