Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection

Gu, Liang; Chen, Bangsheng; Zheng, Dingcheng; Mo, Jiahang; Yuan, Lingling; Mao, Feiyan; Zhang, Kang; Ng, Derry Minyao; Chen, Ping; Wang, Dongjie

doi:10.21203/rs.3.rs-21459/v1

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References 38 publications

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“…SII is an integrated indicator based on peripheral lymphocyte, neutrophil, and platelet counts, and may better reflect the balance of host inflammatory and immune status. Shi et al reported that compared with other systemic inflammatory indices, SII was a reliable index for predicting postoperative survival of GC (33), while Gu et al reported a higher PLR (34), and Zhang et al reported an elevated NLR and PLR were also reliable (35). Wu et al found GC patients with high fibrinogen and low albumin had a poor prognosis, and that FAR was an independent prognostic factor for recurrence after radical resection in GC patients (36).…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin

Lin¹,

Han²,

Meng³

et al. 2022

J Gastrointest Oncol

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Background: Krukenberg tumor (KT) of gastric origin has a poor prognosis. The present study of KTs are mainly case reports and clinical analysis with few samples. Therefore, it is urgent to explore the clinicopathologic characteristics of KTs through large sample studies. To improve the understanding of the clinical diagnosis and treatment of KT, this paper retrospectively analyzed 10 years of gastric cancer (GC) database data, including clinicopathological and prognostic features, aiming to provide a clinical reference for the diagnosis and treatment of the tumor. Methods:The clinicopathological characteristics, treatments, and survival data were collected and analyzed from 130 patients with KTs of GC. Clinicopathological data included clinical manifestations, laboratory findings, imaging reports, pathology and immunohistochemistry (IHC) reports. We collected treatment regimens information on whether they had undergone surgery and chemotherapy and performed survival follow-up. Univariate and multivariate analysis were used to investigate the risk factors of KTs with gastric origin. Results:The median age of the patients was 41 years. A total of 63.1% of patients had synchronous ovarian metastasis, 70.8% had bilateral ovarian metastasis, 68.5% had peritoneum metastasis, and 98.5% had pathologically poorly differentiated adenocarcinoma. The positive rate of human epidermal growth factor receptor 2 (HER-2) was 1.8%. The follow-up rate was 90.8%, and the median overall survival (mOS) of ovarian metastasis was 13.0 months. Univariate analysis showed statistically significant prognostic factors including menstrual status, size of the gastric lesions and ovarian metastases, number of lymph node metastasis, interval to ovarian metastasis, resection of gastric lesions, peritoneal metastasis, oophorectomy, chemotherapy after ovarian metastases, two-drug regimen chemotherapy, albumin, serum cancer antigen 125 (CA-125) levels, platelet count, D-dimer, fibrinogen, and high pretreatment platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Fibrinogen [hazard ration (HR) =0.483; 95% confidence interval (CI): 0.300-0.777; P=0.003], size of ovarian metastasis (HR =1.808; 95% CI: 1.178-2.776; P=0.007), chemotherapy after ovarian metastasis (HR =0.195; 95% CI: 0.101-0.379; P=0.000), peritoneal metastasis (HR =2.742; 95% CI: 1.606-4.682; P=0.000) and oophorectomy (HR =1.720; 95% CI: 1.066-2.778; P=0.026) were independent prognostic factors.Conclusions: GC patients with KTs have some unique clinical features. Hypercoagulable states, peritoneal metastasis, and untimely chemotherapy and oophorectomy might be a worse predictor for KTs derived from gastric origin.

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