Clinical significance of parotid gland incidentalomas on 18F-FDG PET/CT

Makis, William; Ciarallo, Anthony; Gotra, Akshat

doi:10.1016/j.clinimag.2015.03.011

Cited by 25 publications

(11 citation statements)

References 20 publications

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“…As a result of more frequent application of PET/computed tomography (PET/CT) for staging and follow-up of various malignancies, there are more PET/CT reports about abnormal 18F-FDG uptake in unexpected locations such like the parotid gland ( 27 ). FDG-positive parotid incidentalomas occur in less than 14% of PET/CT scans, of which only 4% are malignant.…”

Section: Resultsmentioning

confidence: 99%

“…Warthin’s tumor seems to be the most frequent histology of parotid incidentalomas and show the highest mean standardized uptake value (SUV max ). Nevertheless, PET/CT is unable to differentiate benign from malignant parotid lesions based on SUV max alone ( 27 ). Due to the low frequency of malignant incidentalomas, their management can be performed as for any benign parotid tumor, i.e., FNAC is recommended as a next step.…”

Section: Resultsmentioning

confidence: 99%

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Contemporary Management of Benign and Malignant Parotid Tumors

Thielker

Grosheva

Ihrler³

et al. 2018

Front. Surg.

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To report the standard of care, interesting new findings and controversies about the treatment of parotid tumors.Relevant and actual studies were searched in PubMed and reviewed for diagnostics, treatment and outcome of both benign and malignant tumors.Prospective trials are lacking due to rarity of the disease and high variety of tumor subtypes.The establishment of reliable non-invasive diagnostics tools for the differentiation between benign and malignant tumors is desirable. Prospective studies clarifying the association between different surgical techniques for benign parotid tumors and morbidity are needed. The role of adjuvant or definitive radiotherapy in securing loco-regional control and improving survival in malignant disease is established. Prospective clinical trials addressing the role of chemotherapy/molecular targeted therapy for parotid cancer are needed. An international consensus on the classification of parotid surgery techniques would facilitate the comparison of different trials. Such efforts should lead into a clinical guideline.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Contemporary Management of Benign and Malignant Parotid Tumors

Thielker

Grosheva

Ihrler³

et al. 2018

Front. Surg.

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“…Cross-sectional imaging including CT, MRI and PET are increasingly utilized for evaluation of head and neck clinical problems, increasing the probability of discovering asymptomatic parotid lesions. The prevalence of these lesions is not known on CT and MRI, however their prevalence on PET imaging has been reported in the range of 0.3-0.45 % with reported incidence of malignancy up to 32 % of these lesions [7,9,10]. Knowledge of the risk of malignancy in these incidental lesions will aid the interpreting radiologist and referring physician in counseling patients prior to referral for percutaneous biopsy.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features of incidental parotid lesions

et al. 2021

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Background The purpose of this study is to determine the histopathological spectrum and risk of primary malignancy of asymptomatic parotid lesions incidentally discovered on cross-sectional imaging. Methods Over a 10-year period, 154 patients underwent 163 ultrasound-guided parotid lesion biopsies at our institution. This retrospective chart review included 89 lesions in 87 patients with asymptomatic parotid lesions discovered on cross-sectional imaging studies performed for unrelated clinical indications. The histopathologic findings of all sampled lesions were reviewed. We evaluated the patient demographics and pathological diagnoses of sampled parotid lesions to determine the histopathological spectrum and risk of malignancy. Results The average age was 67.5 years and 92 % were males. 25 % of patients had bilateral lesions. The average size of the parotid lesions was 1.5 cm and 91 % were located in the superficial lobe. 92.1 % of lesions were benign with Warthin tumor being the most common diagnosis followed by pleomorphic adenoma. 2.3 % of lesions were primary parotid malignant neoplasms, while 5.6 % were metastatic lesions in patients with known malignancy. Conclusions The incidence of primary parotid malignant neoplasm in asymptomatic incidentally discovered parotid lesions is low. Imaging or clinical follow-up may be considered in patients with incidental parotid lesions who prefer to avoid biopsy.

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“…More data is available concerning SIs on PET/CT. The frequency of incidental findings on 18F-fluorodeoxyglucose (FDG) PET/CT scans showing 18F-FDG uptake in parotid glands ranged from 0.4% to 1.73% [23][24][25]. Only 4 % of focal parotid incidental uptake (FPIU) turned out to be malignant in the study group of Makis et al [24] and 9.6% in the metaanalysis of Treglia et al [26].…”

Section: Chances Of Detecting Sismentioning

confidence: 99%

“…The frequency of incidental findings on 18F-fluorodeoxyglucose (FDG) PET/CT scans showing 18F-FDG uptake in parotid glands ranged from 0.4% to 1.73% [23][24][25]. Only 4 % of focal parotid incidental uptake (FPIU) turned out to be malignant in the study group of Makis et al [24] and 9.6% in the metaanalysis of Treglia et al [26]. However, Ustun et al [25] reported an incidence of parotid metastases amounting to 36.4% and similarly high values of 45% were reported by Mabray et al [27], where FPIU was frequently a manifestation of the patient's known malignancy (metastasis or lymphoma).…”

Section: Chances Of Detecting Sismentioning

confidence: 99%

WFUMB position paper. Incidental findings of the salivary glands

Białek¹,

Lim

Dong

et al. 2021

Med Ultrason

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A salivary incidentaloma (SI) stands for any focal salivary lesion, independent of size, discovered by any imaging method including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), multimodal positron emis-sion tomography (PET) combined with CT or MRI, or X-ray imaging, performed for another reason, in the absence of known salivary glands’ disease. The article presents a detailed analysis of salivary gland diseases with the emphasis on neoplasms. It describes frequency of SIs found on imaging, their prevalence, epidemiology and clinical significance. The probability of malignancy or malignant transformation of a SI, its imaging features, recommended treatment, management and follow-up, as well as ethical issues, psychological burden, informed decision making, economical consequences and costs are discussed. The general prevalence of SIs is low, but is dramatically increasing over time, and may rise significantly in selected groups of oncologic patients. SIs most frequently turn out to be benign primary neoplasms or pseudotumors, including intraparenchymal lymph nodes. SIs detected by other imaging methods should be subsequently assessed with US. Solid SIs demand ultrasound guided fine-needle aspiration cytology (US-FNAC). Neoplasms should undergo surgery. Post-operative US follow-up is man-datory for malignant tumors and recommended for benign neoplasms.

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Clinical significance of parotid gland incidentalomas on 18F-FDG PET/CT

Cited by 25 publications

References 20 publications

Contemporary Management of Benign and Malignant Parotid Tumors

Contemporary Management of Benign and Malignant Parotid Tumors

Clinicopathological features of incidental parotid lesions

WFUMB position paper. Incidental findings of the salivary glands

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