Clinical Significance of Lymph Node Metastasis in Patients Undergoing Partial Hepatectomy for Hepatocellular Carcinoma

Shen, Xizhong; Li, Huikai; Wu, Feng; Zhang, Ti; Cui, Yunlong; Li, Qiang

doi:10.1007/s00268-010-0400-0

Cited by 72 publications

(60 citation statements)

References 27 publications

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“…Lymph node metastases (LNM), which contribute to the risk of cancer death (3), are found in approximately 7.45% of HCC patients (4). We have reported that LNM in HCC is sensitive to external beam radiotherapy (5), but the quality of life and survival of patients who undergo this procedure remains unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

Xiang

Ren

Fan

et al. 2011

Clinical Cancer Research

112

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Purpose: Hepatocellular carcinoma (HCC) most often develops in patients infected with hepatitis B or hepatitis C virus. Differential gene expression profiling is useful for investigating genes associated with lymph node metastasis (LNM). We screened genes to identify potential biomarkers for LNM in HCC.Experimental Design: RNA was extracted from formalin-fixed specimens of paired intratumoral and peritumoral tissues of patients with lymph node-positive (n ¼ 36) or negative (n ¼ 36) HCC. A cDNAmediated annealing, selection, extension, and ligation assay was done with an array of 502 known cancerrelated genes to identify differentially expressed genes in 20 pairs of patients with or without LNM. Candidate biomarkers were evaluated by using immunohistochemistry and tissue microarrays in an independent cohort of 309 HCC patients who had undergone hepatectomy. Of the 309 patients, 235 (76.1%) patients were infected with hepatitis B.Results: Compared with lymph node-negative patients, lymph node-positive patients had 17 overexpressed genes and 19 underexpressed genes in intratumoral tissues, and 25 overexpressed genes and 22 underexpressed genes in peritumoral tissues. Hypoxia-inducible factor (HIF)-1a, VEGF, and matrix metalloproteinase (MMP)-2 were selected for analysis in the cohort of 309 HCC patients. We found that intratumoral protein levels of HIF-1a, VEGF, and MMP-2 were independent risk factors for developing LNM.Conclusion: We identified 83 cancer genes that were differentially expressed in lymph node-positive and lymph node-negative HCC. Our findings show that the combination of intratumoral HIF-1a, VEGF, and MMP-2 may be useful as a molecular prediction model for LNM.

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Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

Xiang

Ren

Fan

et al. 2011

Clinical Cancer Research

112

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“…Portal vein involvement, lymph node metastasis and extrahepatic metastasis had been found to be poor prognostic variables in multiple studies [22][23][24][25][26]. Portal venous thrombosis can lead to complications of portal hypertension.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of unresectable hepatocellular carcinoma: Comparison of seven staging systems (TNM, Okuda, BCLC, CLIP, CUPI, JIS, CIS) in a Chinese cohort.

Zhang

Shu

et al. 2016

JCO

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“…The prognostic significance of regional (hilar or perihepatic) lymph node metastases remains incompletely defined; although the presence of such nodal metastases seems to be an ominous sign, the prevalence of nodal metastases seems to be low. [9][10][11][12] Although the development of extrahepatic metastases portends a poor outcome, the preneoplastic nature of chronic liver diseases often makes the risk of intrahepatic recurrence higher than the risk of distant metastasis. 13,14 One prognostic variable that has consistently been shown to indicate a higher likelihood of recurrent disease after resection or transplantation is vascular invasion by tumor.…”

Section: Prognostic Variablesmentioning

confidence: 99%

Prognostication Systems as Applied to Primary and Metastatic Hepatic Malignancies

Cho¹

2015

Surgical Oncology Clinics of North America

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Clinical Significance of Lymph Node Metastasis in Patients Undergoing Partial Hepatectomy for Hepatocellular Carcinoma

Abstract: Lymph node metastasis in patients with HCC is closely related to a lower survival rate. Regional lymph node dissection should always be performed to determine the precise stage of the disease. Hepatic resection with regional lymphadenectomy is a safe procedure in patients with HCC.

Cited by 72 publications

References 27 publications

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

Prognosis of unresectable hepatocellular carcinoma: Comparison of seven staging systems (TNM, Okuda, BCLC, CLIP, CUPI, JIS, CIS) in a Chinese cohort.

Prognostication Systems as Applied to Primary and Metastatic Hepatic Malignancies

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