Clinical significance of knowledge about the structure, function, and impairments of working memory

Brodziak, Andrzej; Brewczyński, Adam; Bajor, Grzegorz

doi:10.12659/msm.883900

Cited by 18 publications

(10 citation statements)

References 59 publications

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“…Information in long-term memory is to a great extent outside of our awareness, but can be called into working memory to be used when needed. Some of this information is easy to recall, but some is much more difficult to access” (Brodziak et al, 2013). …”

Section: Conclusion and Glossarymentioning

confidence: 99%

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The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

2017

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This review aims to classify and clarify, from a neuroanatomical, neurophysiological, and psychological perspective, different memory models that are currently widespread in the literature as well as to describe their origins. We believe it is important to consider previous developments without which one cannot adequately understand the kinds of models that are now current in the scientific literature. This article intends to provide a comprehensive and rigorous overview for understanding and ordering the latest scientific advances related to this subject. The main forms of memory presented include sensory memory, short-term memory, and long-term memory. Information from the world around us is first stored by sensory memory, thus enabling the storage and future use of such information. Short-term memory (or memory) refers to information processed in a short period of time. Long-term memory allows us to store information for long periods of time, including information that can be retrieved consciously (explicit memory) or unconsciously (implicit memory).

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Section: Conclusion and Glossarymentioning

confidence: 99%

“…The relationship between short-term memory and working memory is presented variously by different theories. The notion of working memory is broader and more general because it refers to structures and processes used for temporarily stored and manipulated information” (Brodziak et al, 2013). …”

Section: Conclusion and Glossarymentioning

confidence: 99%

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

2017

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“…We emphasized in our previous paper that capacity and proper functioning of WMS in experiments on animals usually is done by means of the Delayed Response Task (DRT) [ 25 ]. Performing this kind of test, the location of a reward is shown to the animal.…”

Section: An Attempt To Formulate a Set Of Memory Tests Equivalent Formentioning

confidence: 99%

“…Contemporary investigations on methods of assessment and improvement of memory are particularly important due to frequent memory impairments in old age, which is important for healthcare in an aging society. The quality of life in the elderly is especially affected by impairments in functioning of the working memory system (WMS) [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

In Search of Memory Tests Equivalent for Experiments on Animals and Humans

2014

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Older people often exhibit memory impairments. Contemporary demographic trends cause aging of the society. In this situation, it is important to conduct clinical trials of drugs and use training methods to improve memory capacity. Development of new memory tests requires experiments on animals and then clinical trials in humans. Therefore, we decided to review the assessment methods and search for tests that evaluate analogous cognitive processes in animals and humans.This review has enabled us to propose 2 pairs of tests of the efficiency of working memory capacity in animals and humans.We propose a basic set of methods for complex clinical trials of drugs and training methods to improve memory, consisting of 2 pairs of tests: 1) the Novel Object Recognition Test – Sternberg Item Recognition Test and 2) the Object-Location Test – Visuospatial Memory Test. We postulate that further investigations of methods that are equivalent in animals experiments and observations performed on humans are necessary.

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“…Among the main types of memory characterized, working memory is important to actively maintain a certain amount of information to allow its manipulation [ 87 ], which is essential during the processing of temporal information [ 88 ]. Variation in normal capacity and deficits in working memory may often be explained by the efficacy and integrity of basal ganglia and dopaminergic neurotransmission [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

Neurochemical changes in basal ganglia affect time perception in parkinsonians

et al. 2018

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BackgroundParkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision making and time perception.AimThis review had a goal to update the relation between time perception and Parkinson’s Disease.MethodologyWe used the PRISMA methodology for this investigation built guided for subjects dopaminergic dysfunction in the time judgment, pharmacological models with levodopa and new studies on the time perception in Parkinson’s Disease. We researched on databases Scielo, Pubmed / Medline and ISI Web of Knowledge on August 2017 and repeated in September 2017 and February 2018 using terms and associations relevant for obtaining articles in English about the aspects neurobiology incorporated in time perception. No publication status or restriction of publication date was imposed, but we used as exclusion criteria: dissertations, book reviews, conferences or editorial work.Results/DiscussionWe have demonstrated that the time cognitive processes are underlying to performance in cognitive tasks and that many are the brain areas and functions involved and the modulators in the time perception performance.ConclusionsThe influence of dopaminergic on Parkinson’s Disease is an important research tool in Neuroscience while allowing for the search for clarifications regarding behavioral phenotypes of Parkinson’s disease patients and to study the areas of the brain that are involved in the dopaminergic circuit and their integration with the time perception mechanisms.

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Clinical significance of knowledge about the structure, function, and impairments of working memory

Cited by 18 publications

References 59 publications

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

In Search of Memory Tests Equivalent for Experiments on Animals and Humans

Neurochemical changes in basal ganglia affect time perception in parkinsonians

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