Clinical Significance of<i>Helicobacter pylori</i>Infection on Psoriasis Severity

Ahmed, Amira; Al-Najjar, Amal Hassan; Alshalahi, Hadeel; Altowayan, Waleed Mohammad; Elgharabawy, Rehab M.

doi:10.1089/jir.2020.0144

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…However, these findings may be a result of confounders or from psoriasis patients being more susceptible to infection. H. pylori may potentiate psoriasis by inducing CD4+ T cell responses [ 222 ], while C. Albicans elicits antibody and Th17 responses [ 223 ]. Patients with treated H. pylori also have a lower severity of psoriasis than untreated individuals, further highlighting their association [ 222 ].…”

Section: Contributors To Barrier Dysregulation In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.

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Section: Contributors To Barrier Dysregulation In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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“…In psoriasis patients with HP infection, eradicating the infection ameliorates psoriasis severity and the patients treated for both psoriasis and HP present rapid improvement compared to patients only treated for psoriasis [28,29].…”

Section: Dermatological Diseasesmentioning

confidence: 99%

Extra Digestive Disease and Helicobacter pylori Infection

Avram,

Cornelia Lazăr,

Olariu

2024

Helicobacter Pylori Infection - An Up to Date on the Pathogenic Mechanisms, Diagnosis and Clinical Management

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Helicobacter pylori infection has been associated with gastric pathology and gastric oncogenesis for many years, but its extra-digestive implications are less known. This chapter aims to provide up-to-date information on its potential role in neurological disease (Alzheimer’s disease, stroke, multiple sclerosis, Parkinson’s disease), dermatological disease (urticaria, rosacea, psoriasis), ophthalmological disease (glaucoma, chorioretinitis, blepharitis), hematologic disease (anemia, thrombocytopenia, neutropenia), as well as cardio-vascular disease (myocardial infarction, coronary atherosclerosis, hypertension), COVID-19, and metabolic pathology (diabetes mellitus, metabolic syndrome). For each group of diseases, a short description will be presented as well as information from published research. It will provide the reader with a global insight into the role of Helicobacter pylori in different pathologies.

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Antibody immune responses and causal relationships in four immune skin diseases: Evidence from Mendelian randomization and Bayesian Weighting (Antibody Responses in Skin Diseases: MR & Bayesian)

Li,

Chen,

et al. 2024

Skin Research and Technology

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BackgroundRecent studies increasingly suggest that microbial infections and the immune responses they elicit play significant roles in the pathogenesis of chronic inflammatory skin diseases. This study uses Mendelian randomization (MR) and Bayesian weighted Mendelian randomization (BWMR) to explore the causal relationships between immune antibody responses and four common skin diseases: psoriasis, atopic dermatitis (AD), rosacea, and vitiligo.MethodsWe utilized summary statistics from genome‐wide association studies (GWAS) for antibody responses to 13 infectious pathogens and four skin diseases. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs) to assess causal relationships using multiple MR methods, including inverse variance weighted (IVW), MR Egger, and weighted median. BWMR was also employed to confirm findings and address potential pleiotropy.ResultsThe IVW analysis identified significant associations between specific antibody responses and the skin diseases studied. Key findings include protective associations of anti‐Epstein–Barr virus (EBV) IgG seropositivity and Helicobacter pylori UREA antibody levels with psoriasis and AD. anti‐chlamydia trachomatis IgG seropositivity, anti‐polyomavirus 2 IgG seropositivity, and varicella zoster virus glycoprotein E and I antibody levels were negatively associated with rosacea, while EBV Elevated levels of the early antigen (EA‐D) antibody levels and HHV‐6 IE1B antibody levels were positively associated with rosacea. H. pylori Catalase antibody levels were protectively associated with vitiligo, whereas anti‐herpes simplex virus 2 (HSV‐2) IgG seropositivity was positively associated with vitiligo. The BWMR analysis confirmed these associations.ConclusionThis study underscores the significant role of H. pylori and other pathogens in these skin diseases, suggesting both protective and exacerbating effects depending on the specific condition. Understanding these pathogen‐immune interactions can lead to the development of more effective, personalized treatments and preventative strategies, ultimately improving patient outcomes and quality of life.

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Clinical Significance ofHelicobacter pyloriInfection on Psoriasis Severity

Cited by 5 publications

References 27 publications

Skin Barrier Dysregulation in Psoriasis

Skin Barrier Dysregulation in Psoriasis

Extra Digestive Disease and Helicobacter pylori Infection

Antibody immune responses and causal relationships in four immune skin diseases: Evidence from Mendelian randomization and Bayesian Weighting (Antibody Responses in Skin Diseases: MR & Bayesian)

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