Clinical Significance of F-18 FP-CIT Dual Time Point PET Imaging in Idiopathic Parkinson’s Disease

Abstract

Purpose The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD). Materials and Methods Twenty-four patients with PD (mean age 69.6) and 18 healthy people (mean age 70.26) underwent two sequential PET/CT scans (dual time point imaging) at 90 and 210 min after F-18 FP-CIT injection. Tracer activity of region of interest was measured in the caudate, putamen and a reference region in the brain from both time points. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were obtained in the control group. The percent change in tracer activity between 90-and 210-min images was calculated. The SOR values and the percent change in tracer activity were compared between the patients and healthy control group. ResultsThe SOR values for the caudate, anterior and posterior putamen at both 90-and 210-min images were significantly reduced in the patients with PD. The lowest P value was obtained for the anterior and posterior putamen (p<0.001) at both time points. There were significant differences of the percent change in tracer activity for the anterior and posterior putamen in the two groups (p=0.01). Conclusions F-18 FP-CIT PET scans at 90 and 210 min after injection are both able to diagnose PD. Therefore, the 90-min image by itself is sufficient for diagnosing PD.

Substantia nigral dopamine transporter uptake in dementia with Lewy bodies

“…FP-CIT PET was acquired using Discovery 600 (General Electric Healthcare, Milwaukee, MI, USA). After 90 min of administration of approximately 185 MBq (5 mCi) FP-CIT 53 , PET images were acquired for 15 min with a 256 × 256 matrix and reconstructed with an ordered-subsets expectation-maximization algorithm in an iso-0.98 mm voxel size.…”

TEP/TDM multi-phase : revue de la littérature

“…Enfin, il est à signaler, par ailleurs, que l'acquisition des images TEP à des temps multiples de l'injection du radiotraceur a é galement é té é tudié e dans le cadre de pathologies non-oncologiques, notamment infectieuses [189][190][191], inflammatoires [192][193][194], l'exploration de plaques d'athé rosclé rose [195][196][197], de pathologies neurologiques [198][199][200][201] ou encore dans la graisse brune [202,203].…”

Diagnostic Performance for Differential Diagnosis of Atypical Parkinsonian Syndromes from Parkinson’s Disease Using Quantitative Indices of 18F-FP-CIT PET/CT

“…Although several studies showed the benefits of dual-phase 18 F-FP-CIT PET/CT in diagnosing PD [ 16 , 17 , 18 ], only a few studies dealing with the dual-phase 18 F-FP-CIT PET/CT to differentiate APS from PD [ 19 , 20 ]. In particular, there was no study suggesting the cut-off value through quantitative analysis.…”