Clinical significance of endothelial cell marker CD34 and mast cell marker CD117 in prostate adenocarcinoma

Foroozan, Mozhdeh; Roudi, Raheleh; Abolhasani, Maryam; Gheytanchi, Elmira; Mehrazma, Mitra

doi:10.1016/j.prp.2017.04.027

Cited by 33 publications

(29 citation statements)

References 47 publications

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“…CD34 is a single-pass transmembrane protein with a molecular weight of 105.120 kDa [ 19 ]. It is expressed on the surface of a variety of cells, particularly on vascular endothelial cells; therefore, CD34 is often used to label vascular endothelial cells [ 20 , 21 ]. Moreover, CD34 is more likely to be expressed on newly-formed vascular endothelium [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer

Wang

Dong

et al. 2020

BMC Cancer

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Backgrounds The association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR and CD34 expression was also investigated to provide evidence supporting the use of NLR for predicting the prognosis of prostate cancer patients. Methods Clinical data of 75 patients diagnosed with prostate cancer by prostate aspiration biopsy were retrospectively analyzed. The correlation between NLR, CD34 expression, and clinicopathological characteristics was analyzed using the χ2 test and one-way analysis of variance. The correlation between NLR and CD34 was determined using the Pearson coefficient. Disease free survival was estimated by Kaplan-Meier analysis. Results Both NLR and CD34 expression were significantly positively correlated with PSA, Gleason score, and clinical stage (P < 0.05 both). Patients in the NLRHigh/CD34High group were characterized by high PSA level and Gleason score and late clinical stage. NLR was positively correlated with CD34 expression (r = 0.529, P < 0.001). Conclusions Pretreatment NLR was a valuable marker of prognosis in prostate cancer. NLR is positively correlated with CD34 expression.

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Section: Discussionmentioning

confidence: 99%

Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer

Wang

Dong

et al. 2020

BMC Cancer

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“…[10] CD117 + MCs showed a denser accumulation in prostate adenocarcinoma (PCa) in comparison with benign prostate tissues that were correlated with the levels of serum prostate-specific antigen (sPSA) and the tumor progression and aggressiveness. [19] Cutaneous T cell lymphomas (CTCL) Infiltration and accumulation of MCs were observed in different rates around CTCL. They accumulate mostly in the area immediately around the tumor.…”

Section: Breast Cancermentioning

confidence: 99%

Role of Mast Cells in Shaping the Tumor Microenvironment

Komi

Redegeld

2019

Clinic Rev Allerg Immunol

223

180

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Early mast cell (MC) infiltration has been reported in a wide range of human and animal tumors particularly malignant melanoma and breast and colorectal cancer. The consequences of their presence in the tumor microenvironment (TME) or at their margins still remain unclear as it is associated with a good or poor prognosis based on the type and anatomical site of the tumor. Within the tumor, MC interactions occur with infiltrated immune cells, tumor cells, and extracellular matrix (ECM) through direct cell-tocell interactions or release of a broad range of mediators capable of remodeling the TME. MCs actively contribute to angiogenesis and induce neovascularization by releasing the classical proangiogenic factors including VEGF, FGF-2, PDGF, and IL-6, and nonclassical proangiogenic factors mainly proteases including tryptase and chymase. MCs support tumor invasiveness by releasing a broad range of matrix metalloproteinases (MMPs). MC presence within the tumor gained additional significance when it was assumed that controlling its activation by tyrosine kinase inhibitors (imatinib and masitinib) and tryptase inhibitors (gabexate and nafamostat mesylate) or controlling their interactions with other cell types may have therapeutic benefit.

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“…CD34 is a single-pass transmembrane protein with a molecular weight of 105.120 kDa [16]. It is expressed on the surface of a variety of cells, particularly on vascular endothelial cells; therefore, CD34 is often used to label vascular endothelial cells [17,18]. Moreover, CD34 is more likely to be expressed on newly-formed vascular endothelium [19].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Peripheral Blood Neutrophil-lymphocyte Ratio and CD34 Expression in Prostate Cancer

Wang

Dong

et al. 2019

Preprint

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Backgrounds The association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR and CD34 expression was also investigated to provide evidence supporting the use of NLR for predicting the prognosis of prostate cancer patients. Methods Clinical data of 75 patients diagnosed with prostate cancer by prostate aspiration biopsy were retrospectively analyzed. The correlation between NLR, CD34 expression, and clinicopathological characteristics was analyzed using the χ2 test and one-way analysis of variance. The correlation between NLR and CD34 was determined using the Pearson coefficient. Disease free survival was estimated by Kaplan-Meier analysis. Results Both NLR and CD34 expression were significantly positively correlated with PSA, Gleason score, and clinical stage (P<0.05 both). Patients in the NLRHigh/CD34High group were characterized by high PSA level and Gleason score and late clinical stage. NLR was positively correlated with CD34 expression (r=0.529, P<0.001). Conclusions Pretreatment NLR was a valuable marker of prognosis in prostate cancer. NLR is positively correlated with CD34 expression.

show abstract

Clinical significance of endothelial cell marker CD34 and mast cell marker CD117 in prostate adenocarcinoma

Cited by 33 publications

References 47 publications

Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer

Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer

Role of Mast Cells in Shaping the Tumor Microenvironment

Correlation between Peripheral Blood Neutrophil-lymphocyte Ratio and CD34 Expression in Prostate Cancer

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