Clinical significance of elevated alpha-foetoprotein (AFP) in patients with chronic hepatitis C without hepatocellular carcinoma in upper EGYPT

Kobeisy, M. A.; Morsy, Khairy Hammam; Galal, Mohammad; Sayed, Sohair K.; Ashmawy, Mohammad M.; Mohammad, Fattahallah M.

doi:10.1016/j.ajg.2012.06.004

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…AFP is linked mainly to the presence of HCC although a lot of evidence supports its diagnostic ability for other conditions . The relation between serum elevation of AFP and liver fibrosis progression was established specially in chronic HCV .…”

Section: Discussionmentioning

confidence: 99%

“…AFP is linked mainly to the presence of HCC although a lot of evidence supports its diagnostic ability for other conditions. 1,4,[7][8][9]11,12,14,[16][17][18] The relation between serum elevation of AFP and liver fibrosis progression was established specially in chronic HCV. 28 Our results showed significant positive correlation between serum levels of AFP and stage of hepatic fibrosis by METAVIR score.…”

Section: Discussionmentioning

confidence: 99%

“…AFP was first discovered in 1956 by Halbrecht and Klibanski in hepatocellular carcinoma (HCC) and other tumors, maternal serum during pregnancy adverse pregnancy outcomes, neural tube defects, and Down's syndrome . AFP serum levels were elevated in acute and chronic HCV especially in presence of steatosis and fibrosis . Different non invasive fibrosis markers are used currently with good acceptability, reliability, and reproducibility .…”

Section: Introductionmentioning

confidence: 99%

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Novel scores combining AFP with non‐invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

Gamil

Alboraie

Elsayed

et al. 2018

Journal of Medical Virology

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Serum levels of alpha-fetoprotein (AFP) were reported to increase in patients with significant or advanced hepatic fibrosis. Combination of non-invasive tests decreases the use of liver biopsy in large proportion of chronic HCV patients. The aim of the study was to compare and combine AFP with commonly used non-invasive fibrosis tests in novel scores for prediction of different stages of hepatic fibrosis. Six hundred and fifty two treatment naïve chronic hepatitis C patients were enrolled. Demographic data, basic pre-treatment laboratory tests including complete blood count (CBC), liver biochemical profile and renal functions test, international normalized ratio (INR) in addition to AFP, liver stiffness measurement (LSM) by Fibroscan and liver biopsies were retrospectively analyzed. AST to Platelet Ratio Index (APRI) and FIB-4 scores were calculated. Different predictive models using multivariate logistic regression analysis were generated and presented in equations (scores) composed of a combination of AFP, LSM plus FIB-4/APRI scores. AFP was correlating significantly with LSM, FIB-4, and APRI scores. Areas under receiver operating characteristic curves (AUROCs) for predicting significant hepatic fibrosis, advanced hepatic fibrosis, and cirrhosis were 0.897, 0.931, and 0.955, respectively, for equations (scores) containing AFP, LSM, and FIB-4. AUROCs for predicting significant hepatic fibrosis, advanced hepatic fibrosis and cirrhosis were 0.897, 0.929, and 0.959, respectively, for equations (scores) containing AFP, LSM, and APRI. The study shows that combining AFP to serum biomarkers and LSM increases their diagnostic performance for prediction of different stages of liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel scores combining AFP with non‐invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

Gamil

Alboraie

Elsayed

et al. 2018

Journal of Medical Virology

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“…AFP was found to be high in benign liver diseases such as hepatitis and cirrhosis (Kobeisy et al, 2012). The levels between 15-100 ng/ml were found in 25% of acute hepatitis cases, levels >100 ng/ml were found in 4.9% of chronic liver disease (Forones et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Requests for Tumor Marker Tests in Turkey Without Indications and Frequency of Elevation in Benign Conditions

Cüre¹,

Cüre²,

Kırbaş³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Although alpha fetoprotein (AFP) is the most widely used serum biomarker for HCC diagnosis, its sensitivity (39-64%) and specificity (76-91%) are not optimal [8-10]. In addition, patients with CH or LC may also show elevated AFP levels [11,12]. Furthermore, liver biopsy is an invasive procedure and not suitable for screening of HCC.…”

Section: Introductionmentioning

confidence: 99%

Serum peptidome patterns of hepatocellular carcinoma based on magnetic bead separation and mass spectrometry analysis

et al. 2013

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BackgroundHepatocellular carcinoma (HCC) is one of the most common cancers in the world,and the identification of biomarkers for the early detection is a relevant target. The purpose of the study is to discover specific low molecular weight (LMW) serum peptidome biomarkers and establish a diagnostic pattern for HCC.MethodsWe undertook this pilot study using a combined application of magnetic beads with Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) technique and ClinPro Tools v2.2 to detect 32 patients with HCC, 16 patients with chronic hepatitis (CH), 16 patients with liver cirrhosis (LC) and 16 healthy volunteers.ResultsThe results showed 49, 33 and 37 differential peptide peaks respectively appeared in HCC, LC and CH groups. A Supervised Neural Network (SNN) algorithm was used to set up the classification model. Eleven of the identified peaks at m/z 5247.62, 7637.05, 1450.87, 4054.21, 1073.37, 3883.64, 5064.37, 4644.96, 5805.51, 1866.47 and 6579.6 were used to construct the peptides patterns. According to the model, we could clearly distinguish between HCC patients and healthy controls as well as between LC or CH patients and healthy controls.ConclusionsThe study demonstrated that a combined application of magnetic beads with MALDI-TOF MB technique was suitable for identification of potential serum biomarkers for HCC and it is a promising way to establish a diagnostic pattern.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1503629821958720.

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Clinical significance of elevated alpha-foetoprotein (AFP) in patients with chronic hepatitis C without hepatocellular carcinoma in upper EGYPT

Cited by 26 publications

References 19 publications

Novel scores combining AFP with non‐invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

Novel scores combining AFP with non‐invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

Requests for Tumor Marker Tests in Turkey Without Indications and Frequency of Elevation in Benign Conditions

Serum peptidome patterns of hepatocellular carcinoma based on magnetic bead separation and mass spectrometry analysis

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