Clinical significance of conventional serum autoantibodies for various liver diseases in a Chinese population

Yang, Zaixing; Liang, Yan; Qin, Bao‐Dong; Li, Chang; Zhong, Ruiqin

doi:10.1016/j.clinbiochem.2011.08.1146

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Previous studies reported that the ANA titres of 26.9% (83/309) of patients with SS and 40.1% (55/137) of patients with PBC were higher than 1:1000 [ 33 , 34 ]. Yang et al Reported that patients with PBC had higher ANA titres [ 40 ]. We speculated that the concomitant occurrence of SS and PBC might enhance the immune response, leading to higher antibody positivity.…”

Section: Discussionmentioning

confidence: 99%

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

et al. 2023

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Background Limited research exists on the laboratory characteristics of coexistent primary biliary cholangitis (PBC) and Sjögren’s syndrome (SS). This study aimed to investigate the laboratory risk factors for the coexistence of PBC in patients with SS. Methods Eighty-two patients with coexistent SS and PBC (median age 52.50 years) and 82 age- and sex-matched SS controls were retrospectively enrolled between July 2015 and July 2021. The clinical and laboratory characteristics of the two groups were compared. Laboratory risk factors for the coexistence of PBC in patients with SS were analyzed using logistic regression analysis. Results Both groups had a similar prevalence of hypertension, diabetes, thyroid disease, and interstitial lung disease. Compared with the SS group, patients in the SS + PBC group had higher levels of liver enzymes, immunoglobulins M (IgM), G2, and G3 (P < 0.05). The percentage of patients with an antinuclear antibody (ANA) titre > 1:10000 in the SS + PBC group was 56.1%, higher than that in the SS group (19.5%, P < 0.05). Additionally, cytoplasmic, centromeric, and nuclear membranous patterns of ANA and positive anti-centromere antibody (ACA) were observed more frequently in the SS + PBC group (P < 0.05). Logistic regression analysis showed that elevated IgM levels, high ANA titre, cytoplasmic pattern, and ACA were independent risk factors for PBC coexistence in SS. Conclusions In addition to established risk factors, elevated IgM levels, positive ACA, and high ANA titre with cytoplasmic pattern provide clues to clinicians for the early screening and diagnosis of PBC in patients with SS.

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Section: Discussionmentioning

confidence: 99%

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

et al. 2023

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“…A recent large study from the NASH Clinical Research Network reported that 21% of patients with well‐phenotyped NAFLD are positive for serum autoantibodies . However, the link between serum autoantibodies and NAFLD seems weak in Chinese populations . Therefore, a complete differentiation for autoimmune liver disease should be considered in patients with high serum titers of autoantibodies.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and management of non‐alcoholic fatty liver disease and related metabolic disorders: Consensus statement from the Study Group of Liver and Metabolism, Chinese Society of Endocrinology (非酒精性脂肪性肝病与相关代谢紊乱诊疗共识——中华医学会内分泌学分会肝病与代谢学组)

Gao

Fan

2013

Journal of Diabetes

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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, affecting 20%–33% of the general population. Large population-based surveys in China indicate a prevalence of approximately 15%–30%. Worldwide, including in China, the prevalence of NAFLD has increased rapidly in parallel with regional trends of obesity, type2 diabetes and metabolic syndrome. In addition, NAFLD has contributed significantly to increased overall, as well as cardiovascular and liver-related, mortality in the general population. In view of rapid advances in research into NAFLD in recent years, this consensus statement provides a brief update on the progress in the field and suggests preferred approaches for the comprehensive management of NAFLD and its related metabolic diseases.

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“…Previous studies reported that the ANA titers of 26.9% (83/309) of patients with SS and 40.1% (55/137) of patients with PBC were higher than 1: 1000 [31,32]. Yang et al reported that patients with PBC had higher ANA titers [35]. We speculated that the concomitant occurrence of SS and PBC might enhance the immune response, leading to higher antibody positivity.…”

Section: Discussionmentioning

confidence: 74%

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

Gao

Xiao

Yang

et al. 2023

Preprint

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Background There is limited research on the laboratory characteristics of coexistent primary biliary cholangitis (PBC) and Sjögren's syndrome (SS). This study aimed to investigate the laboratory risk factors for the coexistence of PBC in patients with SS. Methods Eighty-two patients with coexistent SS and PBC (median age 52.50 years) and 82 age- and sex-matched SS controls were retrospectively enrolled between July 2015 and July 2021. The clinical and laboratory characteristics of the two groups were compared. Laboratory risk factors for the coexistence of PBC in patients with SS were analyzed using logistic regression analysis. Results Both groups had a similar prevalence of hypertension, diabetes, thyroid disease, and interstitial lung disease. Compared with the SS group, patients in the SS + PBC group had higher levels of liver enzymes, immunoglobulins M (IgM), G2, and G3 (P < 0.05). The percentage of patients with an antinuclear antibody (ANA) titer > 1:10000 in the SS + PBC group was 56.1%, higher than that in the SS group (19.5%, P < 0.05). In addition, cytoplasmic, centromeric, and nuclear membranous patterns of ANA and positive anti-centromere antibody (ACA) were observed more frequently in the SS + PBC group (P < 0.05). Logistic regression analysis showed that elevated IgM levels, high ANA titer, cytoplasmic pattern, and ACA were independent risk factors for PBC coexistence in SS. Conclusion In addition to established risk factors, elevated IgM levels, positive ACA, and high ANA titer with cytoplasmic pattern also provide clues to clinicians for the early screening and diagnosis of PBC in patients with SS.

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Clinical significance of conventional serum autoantibodies for various liver diseases in a Chinese population

Cited by 7 publications

References 27 publications

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren’s syndrome: a retrospective study

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