Clinical significance of blood chromogranin A measurement in neuroendocrine tumours

Seregni, Ettore; Ferrari, Leonardo; Bajetta, Emilio; Martinetti, Antonia; Bombardieri, Emilio

doi:10.1093/annonc/12.suppl_2.s69

Cited by 127 publications

(88 citation statements)

References 10 publications

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“…Pancreatic polypeptide is a 36 amino acid protein secreted by endocrine cells located primarily in the pancreatic head and uncinate process, with a low sensitivity of 31% in PNETs (25). Neuron-specific enolase is a biomarker with a sensitivity of 33% and a specificity of 100% in patients with gastroenteropancreatic neuroendocrine tumors (26). It is also an independent predictor of survival for patients with advanced G1/2 PNETs undergoing peptide receptor radionuclide therapy (27).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

Neutrophil-lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors

Luo

Liu

et al. 2017

Oncology Letters

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Abstract.Although the prognostic role of neutrophil-lymphocyte ratio (NLR) has been confirmed in a variety of tumors, the prognostic role of NLR in pancreatic neuroendocrine tumors (PNETs) has not been examined. The present study was performed to assess the role of NLR as a prognostic factor in patients with PNETs. Clinical data were retrospectively retrieved from a single institution. The best cut-off value for baseline NLR levels was determined by the receiver operating characteristic (ROC) curve and area under the ROC curve. The primary event was overall survival and event times were assessed by the Kaplan-Meier method. Potential factors associated with the elevation of NLR in PNETs were examined. A total of 165 consecutive patients with pathologically confirmed PNETs were included in this study. The cutoff value of NLR was 2.4 by ROC curve (area under ROC curve, 0.70). NLR >2.4 was found to be a poor prognostic factor in the univariate and multivariate analyses. Patients with a NLR value >2.4 had a higher proportion of tumor size at >3 cm (P= 0.001), TNM stage III or IV (P= 0.019), and G2/G3 (P= 0.003). We concluded that NLR is an independent predictor of overall survival for patients with PNETs. Aberrant elevation of NLR identifies high-risk patients with aggressive characteristics.

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Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

Neutrophil-lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors

Luo

Liu

et al. 2017

Oncology Letters

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“…Megfi gyelték, hogy a kissejtes tüdőrák szakaszai és a tumor teljes mérete korrelál a termelődő CgA-koncentrá-cióval [41]. A neuroblastomákban és a pajzsmirigy medullaris carcinomájában szintén emelkedett CgA-szintek fi gyelhetőek meg [42].…”

Section: öSszefoglaló Közleményunclassified

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

et al. 2015

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A kromogranin-A a granincsaládba tartozó fehérje, amelyet neuroendokrin sejtek termelnek és ezek szekréciós granulumaiból származik. A kromogranin-A-ból számos, mind ez idáig kevésbé tisztázott funkciójú fehérje képződik. Jelenleg a kromogranin-A vérben mérhető szintjének meghatározását elsősorban neuroendokrin daganatok laboratóriumi diagnosztikájában használják. A legfrissebb kutatások alapján azonban úgy tűnik, a kromogranin-A-ból szár-mazó WE-14 nevű fehérjének szerepe lehet az 1-es típusú cukorbetegség kialakulásában is. A WE-14 fehérje autoantigénként viselkedik a β-sejtek elpusztításában részt vevő T-sejtek számára. Ezt a mechanizmust eddig specifi kusan a nem obes diabetogén egerekben fi gyelték meg. Újabb eredmények alapján a WE-14 a diabeteses egerek mellett az újonnan diagnosztizált 1-es típusú cukorbetegeknél is az autoreaktív sejtek célpontjaként szolgál, amely reakció szö-veti transzglutamináz enzimmel fokozható. A szerzők jelen összefoglalójukban áttekintik a kromogranin-A bioszintézisét, biokémiai jellegzetességeit, szervezetbeli funkcióit, valamint ismertetik a cukorbetegség patomechanizmusá-ban betöltött szerepére vonatkozó jelen ismereteket. Orv. Hetil., 2015, 156(5), 163-170. Kulcsszavak: kromogranin-A, diabetes mellitus, tumormarker, WE-14The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.Keywords: chromogranin-A, diabetes mellitus, tumour marker, Z., Nagy, P., Patócs, A., Somogyi, A. [The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus]. Orv. Hetil., 2015, 156(5), 163-170.

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“…Seregni et al [28] and Sivanello et al [29] also demonstrated that the CgA plasma concentration is elevated in patients with tumors NET and strongly correlates with the severity of the neoplastic process.…”

Section: Discussionmentioning

confidence: 94%

“…However in well differentiated tumors low median value of CgA was observed. According to the Seregni et al [28] and Stivanello et al [29] the CgA plasma concentration in NET patients reflects the differentiation grade of neuroendocrine tumor. Furthermore, Giovanella et al [7] results indicate that a very high CgA concentration is a good prognostic marker and may indicate well-differentiated neuroendocrine carcinomas.…”

Section: Discussionmentioning

confidence: 97%

Significance of plasma chromogranin A determination in neuroendocrine tumour (NET) diagnosis.

Donica

Malecha-Jędraszek²,

Strosławska³

et al. 2011

Folia Histochem Cytobiol.

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Clinical significance of blood chromogranin A measurement in neuroendocrine tumours

Abstract: CgA was confirmed to be the best tumour marker currently available for identifying patients suffering from NETs of the GEP system, lung carcinoids and neuroblastomas. CgA evaluation is recommended in the follow-up of patients with such tumours.

Cited by 127 publications

References 10 publications

Neutrophil-lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors

Neutrophil-lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

Significance of plasma chromogranin A determination in neuroendocrine tumour (NET) diagnosis.

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