The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

Herold, Zoltán; Nagy, Péter; Patócs, Attila; Somogyi, Anikó

doi:10.1556/oh.2015.30087

Cited by 4 publications

(7 citation statements)

References 47 publications

(46 reference statements)

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“…We did not observe one specific trend for all the indicated substances. This finding confirms previous reports showing that these substances could be associated with the T1D course and various late complications [ 26 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Discussionsupporting

confidence: 92%

“…In a number of studies, selected biologically active substances were indicated as contributing to the etiology (IAPP [ 16 , 31 , 32 , 33 , 34 , 35 , 36 ], proIAPP [ 17 , 18 , 37 ], I-FABP [ 24 ]), course (CST [ 38 , 39 ], ChgA [ 40 , 41 , 42 ]) or the development of various complications (neuropathy—NGF [ 43 , 44 , 45 ], cardiovascular complications—PAF [ 26 , 46 , 47 ], and cardiovascular complications and nephropatia—UMOD [ 28 , 48 , 49 ]). In the current study, we assessed the diagnostic usefulness of these indicators present in T1D patients’ sera and confirmed statistically significant differences between their concentrations in the group of children with T1D and healthy children, but only some of them (NGF, ChgA, CST and PAF) were affected by disease duration.…”

Section: Discussionmentioning

confidence: 99%

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Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Ochocińska

Wysocka‐Mincewicz

Swiderska

et al. 2023

JCM

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Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause the production/activation of various proteins and peptides influencing treatment and causing a risk of complications. The aim of this study was to assess concentrations of selected serum substances involved in the pathogenesis and course of T1D and to correlate their concentrations with the duration of T1D. The study included patients with T1D (n = 156) at the age of 3–17, who were divided according to the duration of the disease into those newly diagnosed (n = 30), diagnosed after 3–5 (n = 77), 6–7 (n = 25), and over 7 (n = 24) years from the onset of T1D, and age-matched healthy controls (n = 30). Concentrations of amylin (IAPP), proamylin (proIAPP), catestatin (CST), chromogranin A (ChgA), nerve growth factor (NFG), platelet-activating factor (PAF), uromodulin (UMOD), and intestinal fatty acid binding protein (I-FABP) were measured in sera using immunoenzymatic tests. There were significant differences in concentrations of all the substances except UMOD and NGF between T1D patients and healthy children. The duration of the disease affected concentrations of CST, ChgA, PAF, and NGF, i.e., proteins/peptides which could have an impact on the course of T1D and the development of complications. In long-term patients, a decrease in concentrations of CST and ChgA, and an increase in PAF concentrations were found. In the case of NGF, a decrease was observed after the initial high values, followed by an increase over 7 years after T1D diagnosis. Concluding, the results show that concentrations of selected serum indicators may change in the course of T1D. Further studies are needed to establish whether these indicators could be used in the context of predicting long-term complications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Ochocińska

Wysocka‐Mincewicz

Swiderska

et al. 2023

JCM

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“…Some studies have revealed that CgA may affect blood pressure, obesity, fat levels and pancreatic beta cells. [37][38][39][40] The study of Kogawa et al, on type 2 patients with diabetes, showed that the level of CgA in the saliva and serum of these patients was significantly higher than in the control group. 29 The exact mechanisms of aging and sex and their effects on genetic polymorphisms and serum levels of CgA are not completely understood in subjects with MetS.…”

Section: Discussionmentioning

confidence: 94%

Age and Sex-Related Chromogranin A Gene Polymorphisms and its Association with Metabolic Syndrome Components

Marjani,

Pursharifi,

Sajedi

et al. 2024

JAFES

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Introduction. The purpose of this study was to determine the possible differences in genetic polymorphisms and serum levels of chromogranin A (CgA), according to age and sex, in subjects with and without metabolic syndrome (MetS).Methodology. The genotyping and serum level of CgA and biochemical parameters were measured by the T-ARMS-PCR and PCR-RFLP and ELISA and spectrophotometer methods, respectively.Results. A comparison of males with and without MetS showed significantly lower high-density lipoprotein-cholesterol (HDL-C) levels than those of females.At ages 30-70 years, both sexes showed significant differences in triglycerides (TG), fasting blood sugar (FBS), CgA levels and waist circumference (WC) when compared to the two groups. Both sexes with MetS indicated significant differences in systolic blood pressure (SBP) at ages 40-70 years, while at ages 40-59 years, there was a significant difference in HDL-C level in males.There was a significant correlation between serum levels of FBS, TG, SBP and WC (in both sexes), and CgA in subjects with MetS. Significant correlation was found between HDL-C level and diastolic blood pressure (DBP), and CgA level in males and females, respectively. CgA genotype frequency (T-415C and C+87T polymorphisms) showed no significant differences between males and females with and without MetS, while there was only a significant difference in frequency of the genotypes T-415C when compared to males with and without MetS.Conclusion. The CgA appears to be strongly associated with MetS components in both sexes. Variation in CgA gene expression may affect the T-415C polymorphism in males. This may mean that the structure of CgA genetics differs in different ethnic groups. Differences in the serum level and expression of CgA gene may show valuable study results that it may be expected a relationship between these variables and the MetS.

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“…a pankreasztatin, a β-granin, a kromosztatin, a vazosztatin és a parasztatin (1. ábra). 7 Egyes feltevések szerint további, mind ez ideig még fel nem fedezett hasadási termékek is képződhetnek belőle. 3,8…”

Section: A Kromogranin-a Biológiai Jellemzőiunclassified

A kromogranin-A szerepe diabetes mellitusban humán vizsgálatok és állatkísérletek alapján

Herold¹,

Patócs²,

Doleschall³

et al. 2018

Diabetologia Hungarica

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dr.,(2,3) Doleschall Márton dr.,(4) Somogyi Anikó dr.(1) Összefoglalás A kromogranin-A a granin fehérjecsaládba tartozik, különböző szervek endokrin és neuroendokrin sejtjei termelik. Számos ismert vagy mind ez ideig kevésbé tisztázott funkciójú, kisebb fehérje hasad ki belőle. A klinikumban elsősorban a neuroendokrin sejtes daganatok kimutatására, illetve azok terápiás követésére alkalmazzák. A kromogranin-A és a cukorbetegség kapcsolatának vizsgálata friss kutatási terület. A fehérje diabetesben betöltött pontos szerepe egyelőre nem tisztázott, de erős kapcsolatra utal, hogy az 1-es típusú cukorbetegség modellállataiban, a nem-obes diabeteses egerekben, ha a kromogranin-A gént kiütötték, hím egereknél nem, míg nőstényekben is csak nagyon ritkán alakult ki a betegség, összehasonlítva a vad típusú, nem-obes diabeteses egerekkel. A pankreasztatin szabályozza a cukor-, zsír-és fehérje-anyagcserét a májban és a zsírszövetben. A WE-14 és további kromogranin-A-fragmentumok mind a humán klinikai vizsgálatok, mind egerekkel végzett állatkísérletek alapján a β-sejtek elpusztításában részt vevő CD4 + és CD8 + T-sejtek autoantigénjeiként funkcionálnak. Kontrollszemélyekhez képest a szérumban magasabb kromogranin-A-, pankresztatin-és WE-14-koncentrációkat mutattak ki mind 1-es típusú, mind 2-es típusú és gestatiós diabetesben szenvedő betegekben. A bemutatott adatok alapján a kromogranin-A a diabetes mellitus kialakulásában, patomechanizmusában fontos szerepet játszhat. Az eddigi ismeretek alapján a cukorbetegség és a fehérje további kapcsolatának vizsgálata szükséges.

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The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

Cited by 4 publications

References 47 publications

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Age and Sex-Related Chromogranin A Gene Polymorphisms and its Association with Metabolic Syndrome Components

A kromogranin-A szerepe diabetes mellitusban humán vizsgálatok és állatkísérletek alapján

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