Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study

Liu, Mina; Cai, Xu-Wei; Wen, Yu; Lv, Chao; Fu, Xiaolong

doi:10.18632/oncotarget.5524

Cited by 24 publications

(35 citation statements)

References 12 publications

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“…Our data substantiate this, as signet ring cell carcinoma, a type highly associated with diffuse histology, represented almost half of the gastric tumors diagnosed in YA in this study. The most common histological type of lung cancer in our study was adenocarcinoma (50.79%), followed by squamous cell carcinoma (6.35%), which was also similar to the results of previous reports 14 , 17 , 18 . In addition, most breast tumors were infiltrating ductal carcinomas, and only a small proportion were lobular carcinomas (1.82%).…”

Section: Discussionsupporting

confidence: 93%

Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Cormedi¹,

Lopes²,

Maistro³

et al. 2018

Clinics

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OBJECTIVES:Cancer in young adults represents a great challenge, both biologically and socially, and understanding the unique characteristics of neoplasms in this age group is important to improving care. We aimed to evaluate the most common carcinomas and their characteristics, such as histological type and clinical stage, in young adults in the largest cancer hospital in Latin America.METHODS:The hospital registry was consulted for the period between 2008 and 2014. Young adults were defined as individuals aged 18 to 39 years, and older adults were defined as individuals aged 40 years and older. Differences between age groups were assessed through chi-square tests.RESULTS:Of the 39,389 patients included, 3,821 (9.7%) were young adults. Among the young adults, the most frequent cancer types were the following: breast, lymph node, colorectal, thyroid, testicle, hematopoietic and reticuloendothelial, uterine cervix, brain, soft tissue and stomach; these sites accounted for 74.5% of the observed tumors. Breast, colorectal and stomach cancers were more frequently diagnosed at advanced stages in young adults than in older adults (p<0.001). The most common histological types were infiltrating ductal carcinoma (86.12%) for breast cancer, adenocarcinomas not otherwise specified (45.35%) for colorectal cancer, squamous cell carcinoma not otherwise specified (65.26%) for uterine cervix cancer, signet ring cell adenocarcinomas (49.32%) for stomach cancer and adenocarcinomas not otherwise specified (50.79%) for lung cancer.CONCLUSION:Young adults are diagnosed with cancer at more advanced stages, indicating that health professionals should be aware of cancer incidence in this age group. It is necessary to develop a better understanding of cancer in young adults and to implement dedicated health care strategies for these patients.

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Section: Discussionsupporting

confidence: 93%

Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Cormedi¹,

Lopes²,

Maistro³

et al. 2018

Clinics

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“…In comparison with elderly patients, it has suggested that lung cancer in young patients tends to be more aggressive in nature; however, the performance status of these young patients tends to be better (6,19,21,22).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and treatment strategies for young lung cancer patients

et al. 2019

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Background: The reported age-specific survival rates of lung cancer patients have been largely inconsistent. Management strategies for younger patients and treatment outcomes are not well characterized. Methods: Out of the 4,697 lung cancer patients with treatment history at Tokyo Medical University Hospital between January 2000 and December 2014, 266 patients were <49 years of age. Patient characteristics were investigated, and the association of overall survival (OS) with age, sex, stage, and histological type were investigated. Results: The 1-, 3-, and 5-year survival rates in the ≤49 years age group were 82.9%, 64.6%, and 57.0%. Among surgical cases, the survival rate of patients in the ≤49 years age group was significantly better than that in the 50-69 and ≥70 years age groups (P=0.29 and P<0.0001, respectively). In comparison with the OS rate with clinical stages, I, II, and III (but not with clinical stage IV) in the older than 50 years age group, the rates in the ≤49 years age group were better. The 1-, 3-, and 5-year OS rates of females were higher than those of their males. The 1-, 3-, and 5-year OS rates for lung adenocarcinoma patients were higher than that of lung non-adenocarcinoma patients. Conclusions: Despite the higher proportion of advanced disease, the postoperative survival rate of the younger was higher than that of the older. Aggressive multimodality treatments, including surgery, are more feasible and effective for younger patients as compared with that in older patients.

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“…3,4 Although previous studies have investigated NSCLC outcomes, they tended to evaluate subgroups of patients, such as patients from specific regions, of specific ages, or who underwent surgery, or to focus on the effects of specific histological type or stage on survival. [5][6][7][8][9][10][11] In addition, accumulating evidence of significant racial and socioeconomic status (SES) disparities in the U.S. health care system has been attracting increased attention. We used period analysis in this study to demonstrate the shift in survival time in each decade between 1983 and 2012 and to determine the impacts of race, sex, age, and SES on the survival rates in patients with NSCLC, using data from the SEER program of the National Cancer Institute.…”

Section: Introductionmentioning

confidence: 99%

Survival improvement in patients with non–small cell lung cancer between 1983 and 2012: Analysis of the Surveillance, Epidemiology, and End Results database

Wang

Sun

et al. 2017

Tumour Biol.

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Non-small cell lung cancer is the most common malignancy in males; it constitutes the majority of lung cancer cases and requires massive medical resources. Despite improvements in managing non-small cell lung cancer, long-term survival remains very low. This study evaluated survival improvement in patients with non-small cell lung cancer in each decade between 1983 and 2012 to determine the impact of race, sex, age, and socioeconomic status on the survival rates in these patients. We extracted data on non-small cell lung cancer cases in each decade between 1983 and 2012 from the Surveillance, Epidemiology, and End Results registries. In total, 573,987 patients with non-small cell lung cancer were identified in 18 Surveillance, Epidemiology, and End Results registry regions during this period. The 12-month relative survival rates improved slightly across three decades, from 39.7% to 40.9% to 45.5%, with larger improvement in the last two decades. However, the 5-year-relative survival rates were very low, with 14.3%, 15.5%, and 18.4%, respectively, in three decades, indicating the urgency for novel comprehensive cancer care. In addition, our data demonstrated superiority in survival time among non-small cell lung cancer patients of lower socioeconomic status and White race. Although survival rates of non-small cell lung cancer patients have improved across the three decades, the 5-yearrelative survival rates remain very poor. In addition, widening survival disparities among the race, the sex, and various socioeconomic status groups were confirmed. This study will help in predicting future tendencies of incidence and survival of non-small cell lung cancer, will contribute to better clinical trials by balancing survival disparities, and will eventually improve the clinical management of non-small cell lung cancer.

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Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study

Cited by 24 publications

References 12 publications

Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital

Clinicopathological characteristics and treatment strategies for young lung cancer patients

Survival improvement in patients with non–small cell lung cancer between 1983 and 2012: Analysis of the Surveillance, Epidemiology, and End Results database

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