Clinical response to induction chemotherapy predicts local control and long-term survival in multimodal treatment of patients with locally advanced esophageal cancer

Ståhl, Michael; Wilke, H.; Stuschke, Martin; Walz, Martin K.; Fink, U.; Molls, M.; Siewert, J. R.; Schroêder, M.; Makoski, H. B.; Schmidt, Ulrich; Seeber, S.; Vanhoefer, U.

doi:10.1007/s00432-004-0604-5

Cited by 51 publications

(35 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Weight loss of greater than 10 per cent total bodyweight has been associated with adverse outcome on multivariable analysis among patients with oesophageal cancer who had undergone surgical resection and chemoradiotherapy 38,39 .…”

Section: Discussionmentioning

confidence: 99%

Clinical prognostic scoring system to aid decision-making in gastro-oesophageal cancer

Deans

Wigmore

Beaux

et al. 2007

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical prognostic scoring system to aid decision-making in gastro-oesophageal cancer

Deans

Wigmore

Beaux

et al. 2007

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Stahl et al (19,20) reported that the overall survival rate was significantly higher in clinical responders than in nonresponders and that preoperative CRT improved local progression-free survival. Therefore, CRT is expected to serve ONCOLOGY REPORTS 18: 901-908, 2007 905 Table II.…”

Section: Discussionmentioning

confidence: 99%

Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: Initial clinical results

Hayano

Okazumi²,

Shuto³

et al. 2007

Oncol Rep

View full text Add to dashboard Cite

Abstract. The ability to predict the response to chemoradiation therapy (CRT) by contrast-enhanced CT would be valuable for managing esophageal squamous cell carcinoma. The purpose of this study was to evaluate the usefulness of Perfusion CT to predict the response to CRT in patients with esophageal squamous cell carcinoma. Thirty-one consecutive patients with esophageal squamous cell carcinoma underwent Perfusion CT before CRT. We retrospectively investigated the correlations between Perfusion parameters and the response to CRT. Clinicopathological markers and blood flow were compared in terms of survival. There were 21 clinical responders and 10 non-responders. Clinical responders showed significantly higher pre-CRT blood flow (P=0.0004), significantly higher pre-CRT blood volume (P=0.03) and a significantly shorter pre-CRT mean transit time (P=0.002) than non-responders. For pre-CRT blood flow, accuracy was 90.3% for detection of clinical responders when the cut-off point was set at 50 ml/ 100 g/min. Patients with high blood flow tumors survived significantly longer than those with low blood flow tumors (P=0.006). Multivariate analysis identified blood flow as a significant independent prognostic factor (P=0.01). Therefore, Perfusion CT may help to identify patients with advanced esophageal squamous cell carcinoma who will benefit from CRT.

show abstract

“…The primary multivariate Cox model included tumor stage and grade (American Joint Committee on Cancer criteria, 7th edition, 2009). Age, sex, and presurgery weight loss (Ն 10%) were added in subsequent models [33][34][35] ; given that results were highly stable, multivariate models containing all covariates are reported. For ever smokers, number of pack-years was also included as indicated.…”

Section: Clinical End Points and Statistical Analysismentioning

confidence: 99%

Prognostic Impact of Body Mass Index Stratified by Smoking Status in Patients With Esophageal Adenocarcinoma

Yoon

Lewis²,

Shi

et al. 2011

JCO

View full text Add to dashboard Cite

Purpose Given that smoking affects body mass index (BMI) and survival, stratification by smoking status may be required to determine the true prognostic impact of BMI. Although obesity increases risk for developing esophageal adenocarcinoma (EAC), the prognostic influence of obesity and its potential modification by smoking status is unknown in this disease. Patients and Methods All patients (N = 778) underwent potentially curative esophagectomy. BMI was calculated using measured height and weight at surgery and categorized as obese (≥ 30 kg/m2), overweight (25 to 29.9 kg/m2), or normal (18.5 to 24.9 kg/m2). Cigarette smoking was categorized as never or ever. The association of BMI with disease-specific survival (DSS), disease-free survival (DFS), and overall survival (OS) was determined by Cox regression. Results Excess BMI was significantly associated with DSS in a manner that differed substantially by smoking status (P for interaction = .023). Among never smokers, obesity was significantly associated with adverse DSS (hazard ratio [HR] = 2.11; 95% CI, 1.31 to 3.43; P = .002), DFS (HR = 2.03; 95% CI, 1.30 to 3.18; P = .002), and OS (HR = 1.97; 95% CI, 1.24 to 3.14; P = .004), as compared with normal weight, after adjusting for covariates. By contrast, among ever smokers, obesity was not prognostic, and overweight status was significantly associated with favorable survival in univariate, but not multivariate, analysis. Conclusion Obesity among never smokers was independently associated with two-fold worsening of DSS, DFS, and OS after surgery for EAC, after adjusting for known prognostic factors. These data, in one of the largest reported resected EAC cohorts, are the first to show an adverse prognostic impact of obesity in EAC.

show abstract

Clinical response to induction chemotherapy predicts local control and long-term survival in multimodal treatment of patients with locally advanced esophageal cancer

Cited by 51 publications

References 16 publications

Clinical prognostic scoring system to aid decision-making in gastro-oesophageal cancer

Clinical prognostic scoring system to aid decision-making in gastro-oesophageal cancer

Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: Initial clinical results

Prognostic Impact of Body Mass Index Stratified by Smoking Status in Patients With Esophageal Adenocarcinoma

Contact Info

Product

Resources

About