Clinical response of clozapine as a treatment for delirious mania

Abstract

Delirious mania is an understudied psychiatric disorder with a mortality rate as high as 75%. Previous case studies suggest that electroconvulsive therapy (ECT) may be an effective treatment for delirious mania, though this procedure may not always be a viable option. We describe the case of a 20-year old patient, with no previous psychiatric history, who developed delirious mania over the course of four months. ECT was not a viable option for this patient due to his religious beliefs, so alternative treatment modalities were explored. After failing trials of risperidone and olanzapine, significant improvements in symptoms were exhibited with a trial of clozapine. We propose that clozapine may be an effective option in cases of delirious mania, when ECT is not a viable option. Additional research is still necessary to understand the pathology of this condition and potential treatment modalities.

Effective and underprescribed: what about clozapine?

“…10 The work of Wahid et al published in Mental Illness, Volume 9, Issue 2 (2017), contributes to that bride indication implications of clozapine use. 11 Having that positive evidence in mind there still is a dark side in the clinical use. Because of the sometimes serious somatic side effects of clozapine like myocarditis, cardiomyopathy, seizures and especially the severe neutropenia risk the Federal Food and Drug Administration mandated the monitoring of blood draws when using clozapine.…”

Effective and underprescribed: what about clozapine?

“…published in Mental Illness, Volume 9, Issue 2 (2017), contributes to that bride indication implications of clozapine use. 11 …”