Clinical Relevance of the cagA,vacA and babA2 Virulence Factors ofHelicobacter pylori in Egyptian Patients with Gastroduodenal Diseases.

Toukhy, Naglaa El; Saeed, Amal; Emara, Nashwa M.

doi:10.21474/ijar01/192

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Our study is consistent with previous studies [3,10]. Others [19,20] found no statistically significant association between cagA genotype and gastroduodenal diseases.…”

Section: Discussionsupporting

confidence: 94%

Detection of Helicobacter pylori oipA and dupA genes among dyspeptic patients with chronic gastritis

Elsayed

Musa

Eltabbakh

et al. 2020

Alexandria Journal of Medicine

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Helicobacter pylori (H. pylori): is a microbe with wide genetic diversity that infects the stomach of most people in developing countries, leading to several clinical outcomes among different individuals such as gastritis, ulcers, or gastric cancer. Outer inflammatory protein A (oipA) and duodenal ulcer promoting (dupA) genes are among the possible virulence factors which determine the patient outcome. Aim: To detect oipA and dupA genes of H. pylori among dyspeptic Egyptian patients, and to investigate their correlation with the varying degrees of the associated chronic gastritis. Methods: The study enrolled 50 patients with dyspepsia, attending the Gastrointestinal Endoscopy unit of the Gastroenterology and Tropical Departments at Ain Shams University Hospital for upper gastrointestinal endoscopy, in the period between, June and, December 2019. Four antral gastric biopsies were taken from each patient for polymerase chain reaction assay to detect the virulence genes oipA, dupA, and cagA and for histopathological assessment. Results: Forty patients were H. pylori positive by histopathology and PCR. cagA, oipA, and dupA were identified in 6 (15%), 13 (32.5%), 9 (22.5%) of biopsies, respectively. Both cagA and oipA genes were highly significantly associated with increasing the severity of gastritis. Only oipA virulence gene showed a highly significant association with gastroduodenitis. There was a highly significant moderate association between cagA and oipA genes. Conclusion: oipA could be a virulence biomarker that serves a great value in predicting the progress of gastric mucosal damage in patients with chronic gastritis, and targeting antimicrobial therapy in those patients to prevent severe gastroduodenal diseases.

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“…Our study is consistent with previous studies [3,10]. Others [19,20] found no statistically significant association between cagA genotype and gastroduodenal diseases.…”

Section: Discussionsupporting

confidence: 94%