Clinical Relevance of Nanoparticle Induced Hyperthermia for Drug Delivery and Treatment of Abdominal Cancers

Abstract

Abstract:The aim of this review is to introduce the reader to the potential clinical utility for the delivery of chemotherapy in the context of nanoparticles. We will present traditional methods of hyperthermia and then focus on the clinical technique for using intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination of colorectal cancer. Cellular mechanisms of hyperthermia as well as clinically effective chemotherapeutic agents are discussed. In the past decade carbon and metal nanoparticles have been explored for their ability to induce hyperthermia; however, many of these studies examine nanoparticles for tumor ablation at high temperatures. There are currently few studies that evaluate mild hyperthermia (below 43°C) generated by nanoparticles to enhance the delivery of chemotherapeutic agents. The fundamentals for generation of hyperthermia from carbon and metal nanoparticles is discussed as are the limitations and benefits of specific nanoparticles with chemotherapeutic agents. This review will show that there is significant potential for the use of nanoparticles to induce hyperthermia and increase the delivery of chemotherapeutic agents for treatment of colorectal cancer and other peritoneal disease.

Synergistic effects of cisplatin chemotherapy and gold nanorod-mediated hyperthermia on ovarian cancer cells and tumors

“…The generation of localized MHT by GNRs offers at least two advantages over systemic heating by indirect sources, including hyperthermic intraperitoneal chemotherapy [62,63] and antenna-guided microwave heating [64]. First, GNR-mediated heating can reach steady-state temperatures more quickly: Photothermal MHT in microtiter wells was achieved within 1 min, whereas a heat block required up to 20 min to achieve steady-state MHT (Figure 2).…”

Microniosomes for concurrent doxorubicin and iron oxide nanoparticles loading; preparation, characterization and cytotoxicity studies

“…In addition, niosomes described here have encapsulated MNPs which can generate the required heat during HIPEC. Literature surveys revealed that, uptake of some chemotherapeutics like DOX to the metastatic sites has been increased in the presence of heat which led to the overall survival rate [31]. Moreover, other potential practical application of presented niosomes could be attributed to transarterial chemoembolization (TACC) techniques where in which micro-particles ranging 10-100 lm are used to hamper the blood supply of tumours [32].…”

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

“…Unlike photosensitizers, PTT agents absorb the light, which is then transformed into heat and transferred to the intracellular environment, generating localized hyperthermia. [8][9][10][11] The combination of both PDT and PTT, which are based on different anticancer mechanisms, into a single therapeutic modality offers a highly proficient method to treat ovarian cancer tumors. To avoid multiple administrations of different therapeutic agents and improve patient compliance, it is highly desirable to have a single nanomedicine platform that possesses both the PDT and PTT therapeutic functions.…”