Clinical, radiological, and gene expression analyses in smokers and non‐smokers, Part 2: RCT on the late healing phase of osseointegration

Sayardoust, Shariel; Omar, Omar; Norderyd, Ola; Thomsen, Peter

doi:10.1111/cid.12514

Cited by 20 publications

(33 citation statements)

References 57 publications

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“…Similar results were reported in a recent randomized controlled trial by Sayardoust et al . Authors of the present investigation support the results by Sayardoust et al . as implants placed in smokers and never smokers had rough surfaces.…”

Section: Discussionsupporting

confidence: 93%

“…It has been reported that implant surface characteristics (such as rough and oxidized surfaces) play a role in enhancing osseointegration and bone‐to‐implant contact by mechanically interlocking bone with the rough irregularities on implant surface . In addition, such implant surface modifications have been shown to modulate the molecular activities for reduced inflammation and/or enhanced bone formation in experimental in vivo models ‒ and also around implants in humans . A retrospective, clinical, radiographic case‐control study assessed implant survival and CBL at turned and oxidized implants in periodontitis‐susceptible never smokers and smokers.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 In addition, such implant surface modifications have been shown to modulate the molecular activities for reduced inflammation and/or enhanced bone formation in experimental in vivo models [28][29][30] and also around implants in humans. 31 A retrospective, clinical, radiographic case-control study 32 assessed implant survival and CBL at turned and oxidized implants in periodontitis-susceptible never smokers and smokers. The results showed that CBL was comparable around smokers and never smokers with oxidized implant surfaces; whereas, smokers with turned implants demonstrated higher CBL and implant failure.…”

Section: Discussionmentioning

confidence: 99%

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Peri‐implant soft tissue status and crestal bone levels around adjacent implants placed in cigarette smokers and never smokers: Five‐year follow‐up results

ArRejaie

Al‐Aali

Alrabiah

et al. 2018

Journal of Periodontology

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Background It is hypothesized that peri‐implant soft tissue inflammation and crestal bone loss (CBL) are higher around adjacent implants placed in cigarette smokers compared with never smokers. The aim of the present 5‐years follow‐up retrospective clinical study was to compare the peri‐implant soft tissue status and CBL around adjacent implants placed in cigarette smokers and never smokers. Methods Cigarette smokers (group 1) and never smokers (group 2) with adjacent dental implants were included. Demographic information regarding age, sex, duration of smoking (pack‐years), daily frequency of toothbrushing and most recent visit to a dentist or dental hygienist were recorded using a questionnaire. Information regarding implant dimensions (length × diameter), duration of implants in function, loading protocol (and type of restoration was recorded. Peri‐implant plaque index (PI), bleeding on probing (BOP), probing depth (PD), and mesial and distal CBL were measured. P <0.05 were considered statistically significant. Results Seventy‐two male participants (37 in group 1 and 35 in group 2) were included. The mean age of individuals in groups 1 and 2 were 50.3 ± 5.4 and 48.5 ± 3.8 years, respectively. In group 1, the mean duration of cigarette smoking was 22.3 ± 1.6 pack years. A family history of smoking was more often reported by individuals in group 1 compared with group 2. In groups 1 and 2, 54 and 70 adjacent implants, respectively were placed in the regions of missing premolars and molars. All implants were delayed loaded and were fixed with non‐splinted screw‐retained restorations. In groups 1 and 2, toothbrushing twice daily was reported by 78.3% and 74.2% individuals, respectively. There was no statistically significant difference in peri‐implant PI, BOP, PD, and mesial and distal CBL among individuals in groups 1 and 2. Conclusion Peri‐implant soft tissue status and crestal bone levels were comparable around adjacent dental implants placed in cigarette smokers and never smokers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Peri‐implant soft tissue status and crestal bone levels around adjacent implants placed in cigarette smokers and never smokers: Five‐year follow‐up results

ArRejaie

Al‐Aali

Alrabiah

et al. 2018

Journal of Periodontology

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“…The value of the present observations for the daily clinical work remains to be established in future studies. Nevertheless, recently the PICF molecular data obtained after 1‐28 days in the present study was complemented by molecular PICF data after 60 and 90 days in the same patient cohort . Clinical parameters and radiological assessment of marginal bone loss at 90 days, were correlated with the molecular data of both PICF and baseline bone prior to surgery.…”

Section: Discussionmentioning

confidence: 88%

“…Nevertheless, recently the PICF molecular data obtained after 1-28 days in the present study was complemented by molecular PICF data after 60 and 90 days in the same patient cohort. 39 Clinical parameters and radiological assessment of marginal bone loss at 90 days, were correlated with the molecular data of both PICF and baseline bone prior to surgery. Multivariate regression analysis revealed that some of the detected genes were predictors of marginal bone loss.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Gene expression in peri‐implant crevicular fluid of smokers and nonsmokers. 1. The early phase of osseointegration

Sayardoust

Omar

Thomsen

2017

Clin Implant Dent Rel Res

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During the early phase of osseointegration, postoperative pain is linked to the inflammatory cell response and, may tentatively serve as an indicator of biological complication and implant loss. The present study suggests that smokers have an altered bone composition and (ultra)structure based on the observations that ISQ values are higher and correlate to recipient bone quality and quantity in smokers.

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Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

et al. 2019

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Smoking is a major risk factor for dental implant failure. In addition to higher marginal bone loss around implants, the cellular and molecular responses to injury and implant physicochemical properties are also differentially affected in smokers. The purpose of this work is to determine if smoking impairs bone microstructure and extracellular matrix composition within the dental alveolar socket after tooth extraction. Alveolar bone biopsies obtained from Smokers (> 10 cigarettes per day for at least 10 years) and Ctrl (never-smokers), 7-146 months after tooth extraction, were investigated using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, and Raman spectroscopy. Both Smokers and Ctrl exhibited high inter-and intra-individual heterogeneity in bone microstructure, which varied between dense cortical and porous trabecular architecture. Regions of disorganised/woven bone were more prevalent during early healing. Remodelled lamellar bone was predominant at longer healing periods. Bone mineral density, bone surface-to-volume ratio, mineral crystallinity, the carbonate-to-phosphate ratio, the mineral-to-matrix ratio, the collagen crosslink ratio, and the amounts of amino acids phenylalanine and proline/hydroxyproline were also comparable between Smokers and Ctrl. Bone microstructure and composition within the healing dental alveolar socket are not significantly affected by moderate-to-heavy smoking.

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Clinical, radiological, and gene expression analyses in smokers and non‐smokers, Part 2: RCT on the late healing phase of osseointegration

Cited by 20 publications

References 57 publications

Peri‐implant soft tissue status and crestal bone levels around adjacent implants placed in cigarette smokers and never smokers: Five‐year follow‐up results

Peri‐implant soft tissue status and crestal bone levels around adjacent implants placed in cigarette smokers and never smokers: Five‐year follow‐up results

Gene expression in peri‐implant crevicular fluid of smokers and nonsmokers. 1. The early phase of osseointegration

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

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