Clinical, radiographic and HLA associations as markers for different patterns of psoriatic arthritis

Marsal, Sara; Armadans-Gil, Lluı́s; Martı́nez, Mauricio; Gallardo, Dominique; Ribéra, A; Lience, E

doi:10.1093/rheumatology/38.4.332

Cited by 130 publications

(91 citation statements)

References 1 publication

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“…Macaristan'daki bir çalışmada psoriatik artritlilerde; HLA-Cw6, HLA-B16 ve HLA B27 yüksek oranda pozitif bulunmuştur. HLA B27 pozitifliği; aksiyal tutulum ile güçlü ilişkili, periferik tutulum ile zayıf ilişkili olarak bildirilmiştir 21 . Braun ve ark.…”

Section: Discussionunclassified

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Öğretmen¹,

Hız²,

Sılan³

et al. 2014

TURKDERM

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Backround and Design:Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PASI) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66 (68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls. (Turkderm 2014; 48: 131-4)

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Section: Discussionunclassified

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Öğretmen¹,

Hız²,

Sılan³

et al. 2014

TURKDERM

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“…Gladman [9] psöriazisli hastaların %16'sında sakroiliak tutulum tespit etmiştir. Marsal ve arkadaşları [10] Psöriazisli hastalarda sakroileit olmadan aksiyal iskelet tutulumu oldukça nadirdir. Bu nedenle, hastalarda, vertebral kolon ve sakroiliak eklemde ankiloz oluşmadan, sakroileitin erken tanısı çok önemlidir [7,11].…”

Section: Discussionunclassified

Magnetic resonance imaging findings of sacroiliitis in patients with psoriasis

İnci

İnci²

2013

J Clin Exp Invest

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Objective: The aim of this study was to determine the frequency and characteristic magnetic resonance (MR) imaging features of sacroiliitis in patients with psoriasis disease. Methods:A total of 68 patients who diagnosed with psoriasis in Dermatology department of our hospital between February-2012 and February-2013 were included to our study. All patients were underwent bilateral sacroiliac MR. MR study were performed with the sequences of the coronal T1 weighted turbo spin-echo, T2 weighted and STIR images using a 1,5-T MR device for all patients. Changes in the subchondral bone were classified according to MR signal features.Results: Of these patients, 37 (54.4 %) were male and 31 (45.6 %) were female. The mean age was 32.3±7.8 years, ranging from 16 to 60 years. Mean disease duration was 12.4±8.6 years (2-24 years). While MR imaging findings were normal in 52 (76,5%) patients, signal changes consisted with sacroiliitis were observed in 16 (23.5%) patients. One or more MR lesion consisted with sacroiliitis were observed in a total of 22 sacroiliac joint of 16 patients. The signal abnormalities detected by MR imaging were as follows, Type-1 changes in 6 (27.3%) joints, Type-2 changes in 8 (36.4%) joints, Type-3 changes in 10 (45.5%) joints, erosions in 9 (40.9%) joints, narrowing the joints space in 6 (27.3%) joints and ankylosis in 5 (22.7%) joints. Bulgular: Çalışmaya dâhil edilen hastaların 37'si (%54,4) erkek, 31'i (% 45,6) kadın idi. Yaşları 16-60 yıl arasında değişen hastaların yaş ortalaması 32,3±7,8 yıl olarak bulundu. Hastaların ortalama hastalık süresi 12,4±8,6 yıl (dağılım 2-24 yıl) idi. Toplam 68 psöriazis hastasının 52'sinde (%76,5) sakroileit lehine herhangi bir bulgu saptanmazken, 16 hastada (%23,5) sakroileit ile uyumlu sinyal değişiklikleri izlendi. Sakroileit saptanan 16 hastaya ait toplam 22 sakroiliak eklemde bir ya da birden çok radyolojik lezyonu saptadık. Manyetik rezonans incelemedeki patolojik bulgulara göre sınıflandırıldığında 6 (%27,3) eklemde Tip-1, 8 (%36,4) eklemde Tip-2, 10 (%45,5) eklemde Tip-3 değişiklik bulguları, 9 (%40,9) eklemde erezyon, 6 (%27,3) eklemde eklem mesafesinde daralma ve 5 (%22,7) eklemde ankiloz bulguları izlendi. ConclusionSonuç: Psöriazisli hastalarda sakroileit önemli bir problem teşkil etmektedir. MR görüntüleme psöriazisli hastalardaki sakroileit tanısında, sakroiliak eklem anatomisini ve sakroileit lezyonlarını ayrıntılı olarak gösterebilen ve radyasyon maruziyeti olmayan non-invaziv yararlı bir gö-rüntüleme yöntemidir.

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“…22 If only the father or the mother has the disease, the transmission chance is 14%; when a sibling is affected, that chance is 6%; and when there is no family history that chance is only 2%. 23 Among twins, the incidence of psoriasis is 65% for monozygous twins and 30% for dizygous twins. 20 Currently, that genetic predisposition is attributed to the presence of human leukocyte antigens (HLA).…”

Section: Genetic and Triggering Factorsmentioning

confidence: 99%

Artrite psoriásica: entidade clínica distinta da psoríase?

Ruiz¹,

Azevedo²,

Santos³

2012

Rev. Bras. Reumatol.

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Psoriasis and psoriatic arthritis are complex and heterogeneous clinical entities, whose presentations comprise multiple combinations of subtypes. There are doubts even if they are distinct entities or merely variants of the same disease. Epidemiologically, psoriasis can be considered a common disease because it affects about 2% of the world population. Regarding psoriatic arthritis, there is no consensus in the literature about its true incidence and prevalence in the general population. Genetic, immune, and environmental factors interact culminating in skin and joint manifestations of psoriatic disease. The central role of activated T lymphocytes in the pathogenesis of both psoriasis and psoriatic joints is now recognized. Furthermore, proinfl ammatory cytokines can be found in increased concentrations in both skin and synovium of patients with psoriatic arthritis. Since 1964, when the relationship between psoriasis and psoriatic arthritis was recognized, many studies have been conducted to better understand the common mechanism of both diseases. The HLA has already been considered the center of the psoriatic arthritis immunopathogenesis; today, TNF-α plays such a role. This paper is a review of various factors associating psoriasis and psoriatic arthritis leading to the hypothesis of a single disease with multiple presentations.

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Clinical, radiographic and HLA associations as markers for different patterns of psoriatic arthritis

Cited by 130 publications

References 1 publication

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Magnetic resonance imaging findings of sacroiliitis in patients with psoriasis

Artrite psoriásica: entidade clínica distinta da psoríase?

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