Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Abstract

Backround and Design:Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PASI) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66 (68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls. (Turkderm 2014; 48: 131-4)

Psoriasis and Genetics

“…In Turkish population, we have found that HLA-B27 positivity increased the risk of psoriasis and psoriatic arthritis 5 to 10 times more, respectively [97]. There are various molecular-based hypotheses such as molecular mimicry, defective immunity, heavy chain folding incorrectly, and deterioration of HLA-B27 allele for relationship between HLA-B27 and psoriatic arthritis (PsA) [97].…”