Clinical properties of a novel, glistening-free, single-piece, hydrophobic acrylic IOL

Packer, Mark; Rajan, Mohan; Ligabue, Edoardo; Heiner, Peter

doi:10.2147/opth.s57114

Cited by 35 publications

(20 citation statements)

References 52 publications

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“…89 Another study reported an average EPCO score of 0.032 ± 0.101 for 122 eyes 4 to 6 months after implantation with the enVista lens. 88 Our own reported experience includes over 400 eyes, with no significant IOL-related complications or glistenings. 83 The biocompatibility of the enVista lens was tested in the rabbit model, using the AcrySof lens as the control.…”

Section: Early Experiences With Phs Copolymer Lensesmentioning

confidence: 87%

“…44 Following the change to 0.9% saline solution, no glistenings in this material have been reported. 72,81,88 It is hypothesized that in the case of the lenses stored in 10% saline, the higher salt content within the lens caused an osmotic pressure difference after implantation, which leads to an influx of water and the formation of glistenings. Naturally, the capability of any material formulation to disperse water has limits.…”

Section: Early Experiences With Phs Copolymer Lensesmentioning

confidence: 99%

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New Hydrophobic IOL Materials and Understanding the Science of Glistenings

Tetz¹,

Jorgensen²

2015

Current Eye Research

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An introduction to the history of intraocular lenses (IOLs) is given, leading up to modern hydrophobic examples. The roles of hydrophobicity, hygroscopy, materials chemistry, and edge design are discussed in the context of IOLs. The four major types of IOL materials are compared in terms of their chemistry and biocompatibility. An example of a modern "hydrophobic" acrylic polymer with higher water content is discussed in detail.

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Section: Early Experiences With Phs Copolymer Lensesmentioning

confidence: 87%

Section: Early Experiences With Phs Copolymer Lensesmentioning

confidence: 99%

New Hydrophobic IOL Materials and Understanding the Science of Glistenings

Tetz¹,

Jorgensen²

2015

Current Eye Research

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“…Glistening is fluid filled microvacuoles that form within the IOL optic (especially hydrophobic acrylic IOL) when the IOL is in aqueous environment [25] . New glistening free hydrophobic acrylic IOL that contains different polymer combination and was packaged in solution was recently introduced [26] . radiation.…”

Section: Image Qualitymentioning

confidence: 99%

Current Developments in Monofocal Intraocular Lens Technology

İlhan¹

2017

International Journal of Ophthalmic Research

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First intraocular lens (IOL) implantation was performed by Dr. Harold Ridley. This first IOL was completely different from the IOLs we use today. IOL technology is one of the fastest developing technologies in recent years in ophthalmology. Monofocal in the bag IOL is the most commonly used IOL according to American Society of Cataract and Refractive Surgery (ASCRS) surveys. In developing countries, use of this IOL are almost standart. There are many different monofocal IOL options on the market and determination of appropriate IOL must be individualized for each patient to reach perfect postoperative outcomes. The aim of this manuscript is to investigate different properties of IOLs on the market in light of evidence based medicine and to give hints about the individualizilation of the IOL selection. For this purpose, our manuscript emphasizes different properties of IOLs and does not refer any trademarks of IOLs.

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“…9 Additionally, IOLs, designed with sharp corners at the optic edge, form a physical barrier to cell migration, and reduce but do not eliminate PCO. [10][11][12][13] Although incidence of PCO has decreased since the introduction of sharp-edge IOLs in clinical practice, clinical studies have shown that LECs migrated across the sharp edge of the IOL optic in 58% of cases, preferentially at the optic-haptic junction in both one-and three-piece IOL designs. 10,14 Recently, a disc-shaped haptic design has emerged as an innovative alternative to these traditional IOL designs.…”

Section: Introductionmentioning

confidence: 99%

Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model

Magin¹,

May²,

Drinker³

et al. 2015

Trans. Vis. Sci. Tech.

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Citation: Magin CM, May RM, Drinker MC, Cuevas KH, Brennan AB, Reddy ST. Micropatterned protective membranes inhibit lens epithelial cell migration in posterior capsule opacification model. Tran Vis Sci Tech. 2014;4(2):9, http://tvstjournal. org/doi/full/10. 1167/tvst.4.2.9, doi: 10.1167/tvst.4.2.9 Purpose: To evaluate the ability of Sharklet (SK) micropatterns to inhibit lens epithelial cell (LEC) migration. Sharklet Technologies, Inc. (STI) and InSight Innovations, LLC have proposed to develop a Sharklet-patterned protective membrane (PM) to be implanted in combination with a posterior chamber intraocular lens (IOL) to inhibit cellular migration across the posterior capsule, and thereby reduce rates of posterior capsular opacification (PCO).Methods: A variety of STI micropatterns were evaluated versus smooth (SM) controls in a modified scratch wound assay for the ability to reduce or inhibit LEC migration. The best performing topography was selected, translated to a radial design, and applied to PM prototypes. The PM prototypes were tested in an in vitro PCO model for reduction of cell migration behind an IOL versus unpatterned prototypes and IOLs with no PM. In both assays, cell migration was analyzed with fluorescent microscopy.Results: All SK micropatterns significantly reduced LEC migration compared with SM controls. Micropatterns that protruded from the surface reduced migration more than recessed features. The best performing micropattern reduced LEC coverage by 80%, P ¼ 0.0001 (ANOVA, Tukey Test). Micropatterned PMs reduced LEC migration in a PCO model by 50%, P ¼ 0.0005 (ANOVA, Tukey Test) compared with both IOLs with no PM and IOLs with SM PMs.Conclusions: Collectively, in vitro results indicate the implantation of micropatterned PMs in combination with posterior chamber IOLs could significantly reduce rates of clinically relevant PCO. This innovative technology is a globally accessible solution to high PCO rates.Translational Relevance: A novel IOL incorporating the SK micropattern in a membrane design surrounding the optic may help increase the success of cataract surgery by reducing secondary cataract, or PCO.

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Clinical properties of a novel, glistening-free, single-piece, hydrophobic acrylic IOL

Cited by 35 publications

References 52 publications

New Hydrophobic IOL Materials and Understanding the Science of Glistenings

New Hydrophobic IOL Materials and Understanding the Science of Glistenings

Current Developments in Monofocal Intraocular Lens Technology

Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model

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