Clinical profile of organophosphorus poisoning patients at rural tertiary health care centre

Chintale, Kailas N.; Patne, Sanjay V.; Chavan, S.S.

doi:10.18203/2349-3933.ijam20161074

Cited by 20 publications

(30 citation statements)

References 5 publications

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“…This is comparable study done by Chintale et al, in 2016 in Maharashtra. [18] The study showed male predominance in OP poisoning which was comparable to studies done by Khan et al and Raja et al, The reason behind this may be males are main working group in outdoor field, i.e. They are more involved in spraying crops in the farms.…”

Section: Resultssupporting

confidence: 84%

Clinical Profile of Organophosphate Poisoning at a Teritary Care Teaching Hospital

Shirisha¹,

Sri²,

Prasad³

et al. 2019

IJAPB

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Background: The major occupation in India is cultivation, where pesticides are regularly used for farming. Consumption of organophosphate compound in developing countries like India causes severe adverse effects leading to morbidity and mortality due to their effortless availability and lack of knowledge. To control pests, weeds, or plant disease organophosphorus compounds are used as insecticides. Aim: To study the clinical profile of organophosphate poisoning (OP) on different organ systems of the body. Material and Methods: The present study is prospective observational study carried out in AMC ward of MGMH Warangal, 102 subjects were recruited for the study. Results: Pesticide poisoning was more common in males (75%) than females (25%). Majority of the patients were between the age group of 21-30. The most commonly involved OP compound was Chlorpyrifos. Among 102 patients, 54 patients experienced mild symptoms, 46 patients experienced with moderate symptoms and 2 patients were experienced with severe symptoms. Conclusion: OP poisoning is a serious debilitating condition in AMC requires intensive supportive care, treatment with antidote is necessary as it is affecting different organ systems of the body. As the severity of poisoning in patients of our work is mild to moderate, no extrapyramidal effects were observed.

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Section: Resultssupporting

confidence: 84%

Clinical Profile of Organophosphate Poisoning at a Teritary Care Teaching Hospital

Shirisha¹,

Sri²,

Prasad³

et al. 2019

IJAPB

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“…The most frequent type of complication was respiratory failure in 16.5% followed by coma in 12%. Bilal et al (2014) agreed with these results, Also Chintale et al (2016) reported that respiratory failure was the most common complication.…”

Section: Discussionmentioning

confidence: 58%

“…This finding was in accordance with Ahmed et al (2014) and Banday et al (2015) in which the incidence was highest in patients aged less than 40 years. There were only 2% of all patients included in the study above age of 60 years and this was in agreement with Chintale et al (2016). This could be explained by the vulnerability to various emotional conflicts that can happen during this phase (teenager and middle age groups) of life in which the people are most ambitious and productive (Banday et al, 2015).…”

Section: Discussionmentioning

confidence: 76%

The Role of APACHE II, SOFA, Serum amylase and Lipase in Assessment of Severity and Outcome of Acute Organophosphorus Poisoning

Moussa

Mohamed

Hilal

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All right received. AbstractPoisoning with Organophosphate (OP) compounds is responsible for great morbidities and mortalities all over the world especially in developing countries including Egypt. Scoring systems have been continuously developed to predict outcomes in patients with severe illness, to improve resource allocation and to assist in clinical decision-making particularly for ICU patients. The quest for biomarkers in relation to OP compound poisoning started quite a long time back but cheap and easily measurable biomarkers having prognostic value is the need of the hour. The objective of this study is to evaluate the role of acute physiology and chronic health evaluation II (APACHE II) score, the Sequential Organ Failure Assessment (SOFA) score, serum amylase and lipase in assessing severity and outcome of acute organophosphorus poisoning. A retrospective and prospective study was carried out on 200 patients of acute OP poisoning admitted to the Poison Control Center (PCC), Ain Shams University Hospitals. Information after obtaining the permission of the director of PCC and the regional ethics committee was collected from the sheets and computerized data base of the patients, an informed written consent has been obtained from each patient or from his/her caregiver for inclusion in the prospective part of the study. APACHE II and SOFA scores were calculated to each patient admitted and biochemical analysis of serum amylase and lipase were estimated in the prospective part of the study. The results were revised, coded and organized for statistical analysis. The study results revealed 180 (90%) patients discharged and 20 (10%) patients died. The study showed that there were 76% of patients had APACHE II score ≤ 9, while 12.5% of patients had APACHE II score from 10 to 14, there were 8.5% of patients had APACHE II score from 15 to 24 and APACHE II score was > 24 in 3% of patients. SOFA score in 88.5%of patients was ≤ 6, while in 4.5% of patients SOFA score was from 7 to 9 and in 7%of patients SOFA score was > 9. Hyperamylasemia observed in 83.3% of died and 33.3% of died patients had increased lipase. There was significant difference between discharged and died patients as regards APACHE II score, SOFA Score, serum amylase and lipase. It could be concluded that SOFA score, APACHEII score, serum amylase and lipase had a role in assessment of severity of acute organophosphorus poisoning but only SOFA score, APACHEII score and serum amylase could be used as predictors of outcome. SOFA score is more useful in predicting mortality, and easier and simpler than the APACHEII and serum amylase. From the previous results, our study recommends that predictors of outcome (APACHE II score, SOFA score and serum amylase) should be assessed routinely and as early as possible to evaluate the severity, improve the course of management and deciding the pathway of care.

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“…Study finding is consistent with study conducted by authors. 15,[22][23][24] In this present study, methyl parathion (Metacid) 24 (30.76%) was the commonest OP compound consumed by the victims followed by dichlorovos (Novan) 18 (23.07%).…”

Section: Discussionmentioning

confidence: 90%

“…Present findings were in support with study of various workers. [14][15][16] The reason behind this could be that married individuals come across various challenges in day to day life with more responsibilities and sacrifices that makes them more prone to stress of life. In contrary, a study conducted by Karki et al, in Nepalese population revealed that among the cases of OP poisoning majority (62%) of the victims were unmarried.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic characSociodemographic characteristics and assessment of severity in organophosphorus poisoning in a tertiary care hospitalteristics and assessment of severity in Organophosphorous poisoning in a Tertiary care hospital

2017

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Background: In Nepal pesticide poisoning is a common problem and organophosphorus poisoning (OP) is the most common form of acute poisoning responsible for majority of deaths. However, sufficient data is still lacking from Western region of Nepal. The present study analysed the sociodemographic factors of OP poisoning cases, the association of severity based on admission clinical score (POP scale) and lag time with mortality.Methods: This is a cross-sectional study conducted in patients of organophosphorus poisoning, admitted to our casualty ward during a period of one-year June 2015 to 2016.Results: In this study incidence of OP poisoning was more in females 51 (65.38%) compared to males 27 (34.46%). The commonest age group involved in poisoning was 21-30 years 30 (38.4%). Housewives 32 (41.02%) were the commonest victims of poisoning. Incidence was high during rainy season 34 (43.58%) and mainly during late hours 27 (34.61%) of the day. Majority 24 (30.76%) cases reached hospital within 2 hours of poison intake. Methyl parathion (Metacid) 24 (30.76%) was the commonest OP compound consumed by the victims. Suicide 62 (79.48%) was the main motive of poison intake and financial problem (37.17%) was the main reason behind poison ingestion. In majority of the cases the sign and symptoms were mild (80.76%) in severity. In this study majority of the victims survived (9.30%) with prompt and appropriate treatment.Conclusions: The numbers of OP poisoning cases are increasing every year and poisoning is seen commonly in younger age groups. Therefore, strict legislature on the availability of OP compounds, preventive measures and appropriate health education should be introduced to decrease the incidence.

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Clinical profile of organophosphorus poisoning patients at rural tertiary health care centre

Cited by 20 publications

References 5 publications

Clinical Profile of Organophosphate Poisoning at a Teritary Care Teaching Hospital

Clinical Profile of Organophosphate Poisoning at a Teritary Care Teaching Hospital

The Role of APACHE II, SOFA, Serum amylase and Lipase in Assessment of Severity and Outcome of Acute Organophosphorus Poisoning

Sociodemographic characSociodemographic characteristics and assessment of severity in organophosphorus poisoning in a tertiary care hospitalteristics and assessment of severity in Organophosphorous poisoning in a Tertiary care hospital

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