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Background: In Nepal pesticide poisoning is a common problem and organophosphorus poisoning (OP) is the most common form of acute poisoning responsible for majority of deaths. However, sufficient data is still lacking from Western region of Nepal. The present study analysed the sociodemographic factors of OP poisoning cases, the association of severity based on admission clinical score (POP scale) and lag time with mortality.Methods: This is a cross-sectional study conducted in patients of organophosphorus poisoning, admitted to our casualty ward during a period of one-year June 2015 to 2016.Results: In this study incidence of OP poisoning was more in females 51 (65.38%) compared to males 27 (34.46%). The commonest age group involved in poisoning was 21-30 years 30 (38.4%). Housewives 32 (41.02%) were the commonest victims of poisoning. Incidence was high during rainy season 34 (43.58%) and mainly during late hours 27 (34.61%) of the day. Majority 24 (30.76%) cases reached hospital within 2 hours of poison intake. Methyl parathion (Metacid) 24 (30.76%) was the commonest OP compound consumed by the victims. Suicide 62 (79.48%) was the main motive of poison intake and financial problem (37.17%) was the main reason behind poison ingestion. In majority of the cases the sign and symptoms were mild (80.76%) in severity. In this study majority of the victims survived (9.30%) with prompt and appropriate treatment.Conclusions: The numbers of OP poisoning cases are increasing every year and poisoning is seen commonly in younger age groups. Therefore, strict legislature on the availability of OP compounds, preventive measures and appropriate health education should be introduced to decrease the incidence.