Clinical profile of childhood Guillain-Barre Syndrome

Abstract

Objective: Recognizing the clinical presentation of Guillain-Barre syndrome in children. Design: Retrospective observational study. Setting: Pediatric wards and Paediatric Intensive Care Unit. Method: A medical record files of 52 patients of GBS, between the periods of March 2011 to February 2016 were recovered from Medical Record and Statistics Section of institute. Files were analyzed for demographic data, clinical features, co-morbid conditions, investigations, electrophysiological data, mode and result of treatment and data was analyzed. Result: In our series males are outnumber to female and most of the patients in age group 6-12 years, 48% were belongs to lower socioeconomic status. In 53.8% patients antecedents were present at the beginning of clinical picture and upper respiratory tract infection (28.84%) & diarrohea (19.23%) was noted with predominant occurrence in monsoon season (52%). Bilateral lower limb weakness was noted in all patients and in 61.9% patients were common complaint pain in lower limb. Cranial nerve involvement was evident in 28.85% and bulbar involvement was commonest followed by facial nerve. A 23.07% patients were presented with respiratory involvement, 9 of them (15.38%) were needed assisted ventilation. Dysautonomic sign/symptoms were present in 26.92% with 73.33% had demyelinating pattern of neuropathy and 9.6% mortality. Conclusion: The clinical characteristics of GBS in children are not consistent and differ from geographical area and racial diversity.

Study of clinical profile and outcome in children aged 1-12 years presenting with Guillain Barre syndrome

“…Similar findings were noted by Meshram et al in their study. 18 Similar to other previous studies, in our study 93.3% of children had some antecedent symptoms with URTI (53.3%) being the most common. 11,12,15 Similar findings were noted in studies by Pijl et al and Kalita et al 19,20 However, in study by Rangan et al diarrhoea was the most prevalent antecedent illness.…”

Clinical profile and outcome of Guillain Barre syndrome in a tertiary care hospital

“…1,4,6 Most commonly affected age group is 0-5 years which is consistent with studies done in Iran and against the other studies. 2,4 Most common symptom is motor in the form of ascending paralysis which is similar to other studies. 1,2,5,6,9 Antecedent illness is seen in 40% of cases among which URTI, is most common illness which is similar to other studies.…”

“…2,4 Most common symptom is motor in the form of ascending paralysis which is similar to other studies. 1,2,5,6,9 Antecedent illness is seen in 40% of cases among which URTI, is most common illness which is similar to other studies. 6 In outcome 73.3% children were discharged and mortality was 10% which is similar to other study done in Nagpur, few other studies showed mortality as high as 16.6% in New Delhi, as low as 6.6%in Mumbai.…”

“…6 In outcome 73.3% children were discharged and mortality was 10% which is similar to other study done in Nagpur, few other studies showed mortality as high as 16.6% in New Delhi, as low as 6.6%in Mumbai. 1,2,7 There is a single case of Miller Fischer variant of GBS in our study which was also reported in other studie. 8 Among 30 cases there is a recurrent case of GBS following COVID-19 vaccination who had gap of 4 years in between 2 episodes.…”

Guillain-Barré Syndrome

“…6 In addition to respiratory failure, fatality in Guillain Barre Syndrome is due to serious disturbances in autonomic function. 7 Fluctuation in blood pressure, arrhythmias, bowel and bladder paralysis are cause of serious concern as these add in the morbidity associated with Guillain Barre Syndrome and quite often may be the cause of fatality. 7 This study was conducted to see the frequency and outcome of different autonomic disturbances in Guillain Barre Syndrome so that the need for proper monitoring and timely intervention may be improved.…”