Clinical profile and outcome of early onset sepsis in high risk very low birth weight neonates

Shukla, Omprakash S.; Rawat, Aditi

doi:10.18203/2349-3291.ijcp20180480

Cited by 3 publications

(4 citation statements)

References 9 publications

(11 reference statements)

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“…7 Our study was similar one and it supported the findings of previous studies. The blood culture positivity rate of 40% in our study was similar to studies done by Ahmed ANU et al and Shukla et al 11,12 The high positive culture rate in recent studies than older studies like Mathur M et al, is probably due to improved techniques of bacterial isolation and availability of rapid diagnostic kits. 13 As reported by Ahmed ANU et al, our study shows that incidence of neonatal sepsis is more common in male babies (50.98% vs 28.72%) which could be due to some social factors with bias in gender towards patient treatment.…”

Section: Discussionsupporting

confidence: 90%

“…ANU et al and Rasul C H et al 11,14 Mortality in our study 35% consistent with Ahmed ANU et al and Shukla et al (41%). 11,12 Mortality was higher early onset sepsis than late onset sepsis (50% vs 32%) in accordance with Ahmed ANU et al and in low birth babies than normal weight babies (41.9% vs 11.1%) in accordance with Ahmed ANU et al and Taller SS et al 11,5 In our study mortality due to pseudomonas was highest (66%) and least with Escherichia coli (15%) in accordance with Ahmed ANU et al 11 Funding: No funding sources Conflict of interest: None declared Ethical approval: The study was approved by the Institutional Ethics Committee of Government Medical College Srinagar, Jammu, Jammu and Kashmir, India…”

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confidence: 99%

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Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India

Wani

Ahmed

Irshad³

et al. 2019

Int J Contemp Pediatr

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Background: Neonatal sepsis refers to generalized bacterial blood stream infection in first 28 days of life documented by positive blood cultures. It is one of leading causes of neonatal mortality. Objectives was to study clinicobacteriological, antibiotic sensitivity patterns and mortality of neonatal sepsis.Methods: This prospective study was conducted in the Department of Pediatrics of Government Medical College Srinagar in collaboration with Department of Microbiology of same medical college after ethical clearance from ethical committee of Government Medical College Srinagar. One hundred (100) neonates out of 731 neonates admitted between octomber2007 and September 2008 with signs and symptoms of neonatal sepsis were included in our study by random sampling method. After history, examination and laboratory investigation blood culture results were analyzed by standard statistical methods.Results: The blood culture was positive in 40% of neonates. Fifty one (51) neonates were males while as 49 were females. Sixty three (63) neonates had late onset of sepsis while as 37 had early onset sepsis. The positive blood culture was more common in males, late onset sepsis, babies born in rural areas, home born, vaginal births, preterm and other low birth weight neonates .The gram negative isolates were most common followed by positive ones .The best sensitivity of gram negative isolates was to ciprofloxacin followed by amikacin and cephalosporins while as gram positive isolates were sensitive to imipenum followed by vancomycin. Pseudomonas was most responsive to pipercillin +tazobactum combination. The neonatal mortality was 35% being higher in early onset sepsis and low birth weights.Conclusions: This study depicts a high rate of neonatal sepsis, mainly caused by gram negative organisms followed by gram positive organisms with rising drug resistance that could bear far reaching implications to the times to come, mandating the implementation of sepsis preventive measures and administration of specific antibiotics.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India

Wani

Ahmed

Irshad³

et al. 2019

Int J Contemp Pediatr

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“…A systematic analysis of global, national and regional causes of child mortality in 2013 identified preterm birth complications and infections to be the two major causes of neonatal deaths in India. 14 Kifah and Al-Awayshah study found that incidence of PROM was more in preterm gestation while according to Doyle, 70% of cases of PROM occurred at term and 30% of PROM was preterm. 15,16 The present study also found increased incidence of PROM in term gestation (53%), this results are consistent with Lokhande et al, study.…”

Section: Discussionmentioning

confidence: 95%

“…This result was comparable with the other studies. 14,[17][18][19] The gastric culture positivity rate was 18%, where staphylococcus aureus was commonly grown micro-organism. Contaminant growth occurred in one neonate.…”

Section: Discussionmentioning

confidence: 99%

A study of bacteriological profile and outcome of babies born to mother with Premature rupture of membrane and its correlation with blood and gastric culture

Kamble

Nagargoje

Chopde

2019

Int J Contemp Pediatr

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Background: PROM, a condition that occurs when fetal membranes are ruptured at least one hour before onset of labor. While PROM is observed in 10% of all pregnancies, 60-80% of PROM is observed in term and 20-40% in pregnancies less than 37th gestational week. PROM is the most significant reason for preterm labor. The three causes of neonatal death associated with PROM are prematurity, sepsis and pulmonary hypoplasia. Infants born with sepsis have a mortality rate four times higher than those without sepsis. Objective of the study was correlation of blood and gastric culture positive sepsis in PROM newborns. It helps to find out the incidence of PROM in our locality.Methods: This retrospective study enrolled 90 neonates born to healthy mothers with history of PROM more than 18 hours duration, admitted in SNCU/ward at a tertiary care hospital for six months duration from 1st January 2017 to 30 June 2017. Clinical profile of these Newborn with history of PROM was noted such as birth weight, gender, gestation, duration of membrane rupture, history of maternal fever. For all newborns with PROM, sepsis screen had been sent. The neonatal outcome was also recorded, and the data was collected and analyzed by using frequency and percentages.Results: Gram negative bacilli were the commonest cause of neonatal sepsis and male neonates were more prone to infection. PROM and low birth weight especially, ELBW and VLBW are the common high-risk factors for early onset sepsis. Most common organisms isolated in blood and gastric culture were Klebsiella and Staphylococcus aureus respectively.Conclusions: PROM is a high-risk obstetric condition. Active management is needed to enable delivery within 24 hours of PROM as it offers better neonatal outcome. Morbidity and mortality increase as the duration of PROM increases. This can be reduced by early diagnosis, specific treatment and strict infection control practices in neonatal units.

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Prevalence of thrombocytopenia in neonatal sepsis

Chate¹,

Holikar²,

Nagare³

2019

Indian J Child Health

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Background: The problem of neonatal sepsis is enormous in India and many hospital-based studies have revealed an incidence of 30/1000 live births. Objectives: The objectives of this study were to assess the prevalence of thrombocytopenia in culture-positive neonatal sepsis and to observe the outcome of these neonates. Methods: It was a retrospective observational study which was conducted in neonatal intensive care unit (NICU) of a Rural Medical College between September 2018 and December 2018. We have analyzed the records of all the neonates who were admitted at the hospital during this period. We have only included the cases who were culture positive for sepsis and were below 28 days of age. Data were analyzed statistically and p<0.05 was considered to be statistically significant. Results: About 54 neonates who had culture-positive sepsis and thrombocytopenia treated in NICU. Of 54 culture-positive neonates, the most common isolated microorganism was Klebsiella pneumoniae (21, 38.88%) followed by Pseudomonas (15, 27.77%), Staphylococcus (9, 16.66%), and Escherichia coli (9, 16.66%). Thrombocytopenia was present in 49/54 (90.74%) cases. As per severity grading, severe thrombocytopenia was found in 21 (42.86%) neonates, moderate in 17 (34.69%), and mild in 11 (22.45%). The mortality rate among newborns with sepsis was 32.65%. The average period for platelets to rise >100,000/mm3 was 5.0 days (interquartile range 4.0–7.0). Conclusion: Severe thrombocytopenia was commonly associated with neonatal sepsis. Antibiotics covering these groups of bacteria can be started empirically after collecting the required investigations.

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Clinical profile and outcome of early onset sepsis in high risk very low birth weight neonates

Cited by 3 publications

References 9 publications

Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India

Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India

A study of bacteriological profile and outcome of babies born to mother with Premature rupture of membrane and its correlation with blood and gastric culture

Prevalence of thrombocytopenia in neonatal sepsis

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