Clinical profile and outcome of neonatal thrombocytopenia in a tertiary care hospital

Meena, Sumarth Lal; Singh, Kanwar; Jain, Sanjiv; Jain, Anil K.; Karnawat, B. S.

doi:10.18203/2349-3291.ijcp20192041

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…8 Regional data from India found 46% of neonates with TCP in NICU to have mild TCP while 35% had moderate TCP while 19% were having severe TCP. 12 These findings from India are relatively similar to what has been shown in this research. Khalessi N and colleagues as well as Ghamdi AM et al also reported somewhat similar distribution of TCP among neonates in NICU.…”

Section: Resultssupporting

confidence: 89%

“…2,15 As we know, sepsis might be leading to TCP because of relatively lower production of platelets and higher rates of destruction; these could be the reasons behind this exaggerated proportion of sepsis and its linkage with TCP in this study. 12 Some others have shown sepsis as well as birth asphyxia to have significant linkage with neonatal TCP but we did not find any significant connection of birth asphyxia with TCP in this study. 2,5 This study had some limitations as well.…”

Section: Resultscontrasting

confidence: 88%

“…Meena SL et al observed anemia (48.0%) to be the most common maternal risk factors among neonates having TCP in NICU. 12 We also found maternal anemia to have significant association with increased severity of TCP. Tirupath K et al revealed TCP to be significantly linked with maternal anemia among neonates in NICU.…”

Section: Resultssupporting

confidence: 53%

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Thrombocytopenia in neonatal intensive care unit at a tertiary care hospital of South Punjab, Pakistan.

Hussain¹,

Anwar

Ali³

et al. 2023

TPMJ

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Objective: To find out fetal and maternal factors linked with thrombocytopenia (TCP) among neonates admitted in neonatal intensive care unit (NICU) of a tertiary care hospital of South Punjab, Pakistan. Study Design: Cross-sectional study. Setting: The NICU of Sadiq Abbasi Hospital, Bahawalpur. Period: May 2022 to August 2022. Material & Methods: A total of 146 neonates of both genders admitted to NICU having TCP were analyzed. Neonatal TCP was categorized as mild (>100,000/ul to < 150,000/ul), moderate (>50,000/ul to 100,000/ul) and severe (<50,000/ul). Associations of baseline characteristics, fetal factors and maternal factors with categories of TCP were checked applying chi-square test considering p-value ≤0.05 as significant. Results: In a total of 147 neonates with TCP, 84 (57.5%) were male. Mean age was calculated to be 3.9±3.6 days while 109 (74.7%) neonates were aged between 1 to 3 days. Distribution of TCP categories showed that 78 (53.4%) neonates were having mild TCP, 43 (29.5%) moderate TCP whereas remaining 25 (17.1%) neonates were having severe TCP. Stratification of TCP with respect study variables showed that maternal anemia (p=0.0467), pre-term birth (0.0001) and sepsis (p<0.0001) among neonates were significantly linked with severity of TCP. Conclusion: Most neonates admitted to NICU were having mild to moderate degree of thrombocytopenia. Severe degree of thrombocytopenia was found among neonates with history of maternal anemia, pre-term birth and sepsis.

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Section: Resultssupporting

confidence: 89%

Section: Resultscontrasting

confidence: 88%

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Thrombocytopenia in neonatal intensive care unit at a tertiary care hospital of South Punjab, Pakistan.

Hussain¹,

Anwar

Ali³

et al. 2023

TPMJ

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“…Etiological profile in the present study showed 36 (42.3%) cases presenting with neonatal septicemia as the most Meena SL et al [2] and Kripa Nath Mishra et al [1]. According to Jeremiah et al [13], birth asphyxia (33.3%) was most common which is followed by jaundice (19.7%).…”

Section: Discussionmentioning

confidence: 48%

“…It increases mortality, especially in septicemic cases. Multiple disease processes cause thrombocytopenia in neonates and these are classified as early-onset (<72 hours) and late-onset (>72 hours) neonatal thrombocytopenia [2].…”

Section: Introductionmentioning

confidence: 99%

Patterns of Neonatal Thrombocytopenia with A Note on Platelet Indices and Optical Technology – A Cross-Sectional Study

Pallivilla¹,

Gudeli²,

Ledalla³

et al. 2022

Ann of Pathol and Lab Med

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Introduction: Neonatal thrombocytopenia is defined as a platelet count <150×10^9/L regardless of gestational-age. It results from hypo-proliferation in marrow or peripheral destruction of platelets. Platelet count can be rapidly measured using automated hematology analyzers, but peripheral smear remains best method. The causes of neonatal thrombocytopenia are defined by time of presentation into foetal (mainly TORCH infections), early (< 3 days), and late. The present study highlights pattern and severity of neonatal thrombocytopenia in study hospital, adding importance of platelet indices and optical technology. Aim: To study patterns and severity of neonatal thrombocytopenia, platelet indices and to measure accuracy of platelet count by optical technology methods against peripheral smear. Materials and methods: A cross-sectional study done for a period of 8 months from December 2018 to July 2019, at ASRAM medical college, Eluru. During this period blood samples of 113 critical cases of newborns, admitted with thrombocytopenia, were collected in Ethylenediamine tetra acetic acid (EDTA) vials. The platelet count was analyzed by two automated analyzers, Sysmex XN1000 and Horiba ABX Pentra XL 80. The Leishman-stained films were examined under a light microscope. ANOVA test was used to find mean difference between platelet counts, sensitivity, and specificity, and accuracy was calculated by MEDCALC CALCULATOR. Results: Out of total of 113 critical cases of new-borns admitted to Neonatal intensive care unit (NICU) at institute, 85 presented with thrombocytopenia. The variation of platelet indices was noted in 40 cases, blood cultures were collected in 77 cases. Thrombocytopenia showing platelet count less than 20,000/ mm3 is considered very severe, with 30.5% (26 cases) of total number. Elevated platelet indices were noted at 47.5%. The common clinical diagnosis was neonatal sepsis (42.3%), followed by neonatal jaundice (18.8%). The light scatterer principle of platelet evaluation proved to have better accuracy than electrical impedance, in comparison to peripheral smear findings. Conclusion: The study concludes that neonatal septicemia is major cause of neonatal thrombocytopenia as proved by correlating platelet count with platelet indices. And also, usage of automated hemogram reports with platelet indices, is a source of information to suspect etiology of thrombocytopenia thereby preventing adverse outcomes. The principle of Optical Light scatterer technique in an automated analyzer gives better results than the electrical impedance technique for detecting platelet count value, though peripheral smear examination is mandatory for confirmation.

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Prevalence and Outcome of Thrombocytopenia and Its Correlation With CRP in Neonatal Intensive Care Unit

Rajyam

Sagna²

2021

IJAR

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Introduction: Neonatal thrombocytopenia, one of the most common hematological abnormalities in neonates particularly in premature and sick neonates. The aim of this study to study the prevalence and outcome of Thrombocytopenia and its correlation with CRP in the neonatal intensive care unit. Objectives: 1. To nd the prevalence of Thrombocytopenia in the Neonatal intensive care unit in King George Hospital. 2. Factors that predisposing to Thrombocytopenia in neonates 3. Outcomes of thrombocytopenia in neonates. 4. Correlation of thrombocytopenia with the C-reactive protein (CRP) in neonates. Materials And Methods: It is a cross -sectional study in 80 Newborns less than or equal to 28 days admitted in NICU, king George hospital, Visakhapatnam from JANUARY 2019 to JUNE 2020 over period of 18 months. Data is collected from the medical records. Results: The prevalence of thrombocytopenia in this study is 40% with early-onset thrombocytopenia being 65% whereas, that of late-onset thrombocytopenia is 35% ,strong assosciation is found between thrombocytopenia and sepsis ,with mild to moderate variety being (86.4%) and (40%) of severe thrombocytopenia group. Of 80 newborns ,90% of severely thrombocytopenic group have positive CRP, whereas it is 40.9% in the mild to moderate group and 1.4% in normal group.40% of severe thrombocytopenic group had elevated PT, APTT, INR. There was higher proportion of bleeding (45.5%) in severe thrombocytopenia group. gastrointestinal bleeding constituted for 36.4% and intracranial bleeding 2.1% . Conclusion: Positive septic workup is signicantly association with thrombocytopenia, CRP was signicantly association with thrombocytopenia in this study

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Clinical profile and outcome of neonatal thrombocytopenia in a tertiary care hospital

Cited by 4 publications

References 7 publications

Thrombocytopenia in neonatal intensive care unit at a tertiary care hospital of South Punjab, Pakistan.

Thrombocytopenia in neonatal intensive care unit at a tertiary care hospital of South Punjab, Pakistan.

Patterns of Neonatal Thrombocytopenia with A Note on Platelet Indices and Optical Technology – A Cross-Sectional Study

Prevalence and Outcome of Thrombocytopenia and Its Correlation With CRP in Neonatal Intensive Care Unit

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