Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Varshney, Garima; Varshney, Deepak; Mehr, Virendra; Kela, Gunjan; Kharia, Rakhi; Agrawal, Gaurav; Gupta, Rupali

doi:10.14260/jemds/2015/779

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Those clients get out of DKA in greater than 72 hours were 6.39 times more likely to stay in hospital as compared with those clients get out of DKA less than 24 hours(AOR=6.39 ,95%CI=1.09-37.50). This might be due to differences in hyperglycemia state, clinical presentation and delay in management (41,46).…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Meseret

2021

Preprint

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Background: Length of hospital stay and overall in hospital mortality of diabetic keto acidosis during management are the foremost primary out comes that should be measured. Because, it is highly trusted on the improvement of diabetic keto acidosis related complication management. However, data associated to length of stay, mortality rate due to diabetic keto acidosis remains to be limited in Ethiopia.In addition to this, Nonfiction is much scarce in relation to factors associated with treatment outcome starting from its initial presentation and the overall management process. Objective: To assess treatment outcome of children<15 years old admitted with diabetic keto acidosis at Felege Hiwot comprehensive referral hospital, North West, Ethiopia, 2021Methods: Retrospective cross sectional study was conducted at Felege Hiwot comprehensive referral hospital among randomly selected sample of 176 children admitted with diabetic keto acidosis from 2016 to 2021.Data were collected by using data abstraction tool. Then it was coded, enter, cleaned and stored into Epi-data version 4.2 and was exported into STATA 14.0 statistical software for analysis. Categorical variables were described using proportions and compared using Chi-square test; whereas continuous parametric variables with mean and standard deviation and compared using parametric (t-test). Model goodness-of-fit and assumptions were checked. Finally, association between independent variables and length of hospital stay were assessed using binary logistics regression and Variables with p-value < 0.05 were considered as statistically significant.Result: The mean length of hospital stay was 9.5±6.2 days. About 59.3% of had long hospital stay (>7days).Majority of the clients (97.5%) were improve and discharged with 14.2% management complication and 4(2.5%) died in the hospital. Factors that affect long hospital stay were residence(AOR=4.31;95CI=1.25-14.80),family history of diabetes (AOR=0.12; 95%CI=0.02-0.64),glycaemia at admission (AOR=1.01;95%CI=1.00-1.02),insulin skipping (AOR=0.08;95%CI=0.01-0.98),abdominal pain(AOR=4.28;95%CI=1.11 -15.52), time in which the patient get out of diabetic keto acidosis(AOR=6.39;95%CI=1.09-37.50).Conclusion and Recommendation: Majority of clients were showed improvement and discharged to their home after longer hospital stay and with very low mortality rate followed by complication (14.2%).The time with in which the majority of the clients get out of DKA were found in between 24-48 hours. Thus, to achieve the intended treatment out come early in time, modification of the approach by emphasizing the above predictors is mandatory with the recommendation of multicenter study in this regard.

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Section: Discussionmentioning

confidence: 99%

Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Meseret

2021

Preprint

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“…Thời gian hết toan trung bình là 22,50 giờ tương đương với Varshney (2015) ở Ấn Độ khi thời gian hết toan trung bình là 26 giờ 7. Trong khoảng 24 giờ sau khi bắt đầu điều trị bệnh nhân sẽ hết toan.…”

Section: Bàn Luậnunclassified

Một Số Yếu Tố Liên Quan Đến Khởi Phát, Mức Độ Nặng Và Kết Quả Điều Trị Nhiễm Toan Ceton Do Đái Tháo Đường Type 1 Ở Trẻ Em Và Vị Thành Niên

Dũng¹,

Thanh²

2021

VMJ

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Đái tháo đường (ĐTĐ) type 1 là một trong những bệnh lý nội tiết phổ biến nhất ở trẻ em. Nhiễm toan ceton (NTCT) là một biến chứng cấp hay gặp ở bệnh nhi mắc ĐTĐ type 1, đây là biến chứng rất nặng của bệnh, gây tử vong nếu không được chẩn đoán và điều trị kịp thời. Ở trẻ nhỏ, đặc biệt dưới 2 tuổi, khả năng tiếp cận với các dịch vụ y tế thấp, dân tộc thiểu số, và chẩn đoán sai là các yếu tố nguy cơ của NTCT. Mục tiêu: mô tả một số yếu tố nguy cơ, mức độ nặng NTCT của bệnh nhi ĐTĐ type 1, và nhận xét kết quả điều trị NTCT. Đối tượng nghiên cứu: 212 bệnh nhi được chẩn đoán đái tháo đường type 1 lần đầu từ tháng 6/2015 đến 6/2020 tại bệnh viện Nhi Trung ương. Phương pháp: nghiên cứu một loạt ca bệnh. Kết quả: 60/212 bệnh nhân (28,3%) có NTCT; nồng độ C-peptid dưới 1,1 ng/ml làm tăng nguy cơ NTCT lên 5,13 lần (95% CI:1,72–15,29), tăng nguy cơ NTCT mức độ nặng lên 2,13 lần, (95% CI:0,20–22,21); chẩn đoán nhầm làm tăng 6,42 lần nguy cơ NTCT mức độ nặng, (95% CI:1,20–34,19). Thời gian hết toan trung bình là 22,5 giờ. Suy thận cấp gặp ở 30% bệnh nhân NTCT. Không có bệnh nhân tử vong. Kết luận: Bệnh nhân được chẩn đoán ĐTĐ type 1 lần đầu ở Bệnh viện Nhi Trung ương có tỷ lệ NTCT cao. Nồng độ C-peptid dưới 1,1ng/ml, chẩn đoán nhầm là các yêu tố gây gia tăng nguy cơ và mức độ NTCT. Suy thận cấp là biến chứng hay gặp trong NTCT.

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Treatment Outcome and Associated Factors among Type 1 Diabetic Children Admitted with DKA in Bahir Dar City Public Referral Hospital, Northwest, Ethiopia: A Cross-sectional Study

Meseret,

Muluken,

Gebru Gebi

et al. 2024

Global Pediatric Health

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Background. Outcomes that should be measured during diabetic ketoacidosis management is crucial. However, data associated to this was limited in Ethiopia. Methods. A cross-sectional study was conducted among children with diabetic keto acidosis between 2016 and 2021.Data were stored in Epi-data version 4.6 and exported into STATA 14.0 software for analysis. The association between independent variables and length of hospital stay was assessed using binary logistic regression. Finally, variables with P-value <.05 were considered statistically significant. Result. Median length of hospital stay was 8 ± 6.2 days. Majority of patients (97.5%) improved and discharged. Factors that affected longer hospital stay were Residence(aOR = 4.31;95% CI = 1.25-14.80),family history of diabetes (aOR = 0.12; 95% CI = 0.02-0.64), glycemia at admission (aOR = 1.01; 95% CI = 1.00-1.02),insulin skipping (aOR = 0.08; 95% CI = 0.01-0.98), abdominal pain (aOR = 4.28; 95% CI = 1.11-15.52) and time in which the patient get out of diabetic ketoacidosis(aOR = 6.39; 95% CI = 1.09-37.50). Conclusion. Majority of patients showed improvement and discharged to homes after a long hospital stay. Majority of patients resolved from diabetic ketoacidosis between 24 and 48 hours.

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Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Cited by 3 publications

References 16 publications

Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Một Số Yếu Tố Liên Quan Đến Khởi Phát, Mức Độ Nặng Và Kết Quả Điều Trị Nhiễm Toan Ceton Do Đái Tháo Đường Type 1 Ở Trẻ Em Và Vị Thành Niên

Treatment Outcome and Associated Factors among Type 1 Diabetic Children Admitted with DKA in Bahir Dar City Public Referral Hospital, Northwest, Ethiopia: A Cross-sectional Study

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Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Cited by 3 publications

References 16 publications

Treatment Outcome and Associated Factors among Type 1 Diabetic Children&lt;15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Treatment Outcome and Associated Factors among Type 1 Diabetic Children&lt;15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Một Số Yếu Tố Liên Quan Đến Khởi Phát, Mức Độ Nặng Và Kết Quả Điều Trị Nhiễm Toan Ceton Do Đái Tháo Đường Type 1 Ở Trẻ Em Và Vị Thành Niên

Treatment Outcome and Associated Factors among Type 1 Diabetic Children Admitted with DKA in Bahir Dar City Public Referral Hospital, Northwest, Ethiopia: A Cross-sectional Study

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Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study

Treatment Outcome and Associated Factors among Type 1 Diabetic Children<15 Years Admitted With DKA in Bahir Dar City Public Referral Hospital, North West, Ethiopia: A retrospective Cross Sectional Study