Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

Qiu, Wei; Wu, Jing-Shan; Castley, Alison; James, Ian; Joseph, Joyce Pauline; Christiansen, Frank; Carroll, William M.; Mastaglia, Frank; Kermode, Allan G.

doi:10.1016/j.jocn.2009.12.011

Cited by 22 publications

(14 citation statements)

References 32 publications

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“…These findings are in line with the results of other studies from Australia [26], Turkey [27], and Spain [28] demonstrating that a higher frequency of the HLA DRB1*15 allele could be associated with OCBs. Australian researchers in their cohort trial demonstrated that the presence of OCBs might also be related to the HLA DRB1*03 and *04 alleles [29].…”

Section: Discussionsupporting

confidence: 92%

“…The detection of the HLA DRB1*04 and *09 alleles might be related to a greater number of MRI changes and more rapid progression of disability [25], while in our study, these alleles, especially HLA DRB1*09, appeared to be observed quite rare and had no influence on the clinical signs of MS [13]. The HLA-DRB1*0801 allele was associated with older age at onset [23,26], but in the present study, this allele was related to a relatively better course of the disease and less severe disability.…”

Section: Discussionmentioning

confidence: 62%

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The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania

et al. 2013

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BackgroundThe association of HLA DRB1 alleles with susceptibility to multiple sclerosis (MS) has been consistently reported although its effect on the clinical features and disability is still unclear probably due to diversity in ethnicity and geographic location of the studied populations. The aim of the present study was to investigate the influence of HLA DRB1 alleles on the clinical features and disability of the patients with MS in Lithuania.MethodsThis was a prospective study of 120 patients with MS. HLA DRB1 alleles were genotyped using the polymerase chain reaction.ResultsThe first symptoms of MS in patients with HLA DRB1*15 allele manifested at younger age than in those without this allele (28.32 +/− 5.49 yrs vs. 30.94 +/− 8.43 yrs, respectively, p = 0.043). HLA DRB1*08 allele was more prevalent among relapsing-remitting (RR) MS patients than among patients with progressive course of MS (25.0% vs. 8.3%, respectively, chi^2 = 6.000, p = 0.05). MS patients with this allele had lower relapse rate than those without this allele (1.00 +/− 0.97 and 1.44 +/− 0.85, respectively, p = 0.043). Degree of disability during the last visit was lower among the patients with HLA DRB1*08 allele (EDSS score 3.15 +/− 1.95 vs. 4.49 +/− 1.96, p = 0.006), and higher among those with HLA DRB1*15 allele (EDSS score 4.60 +/− 2.10 vs.4.05 +/− 1.94, p = 0.047) compared to patients without these alleles but there were no significant associations between these alleles and the duration of the disease to disability. HLA DRB1*08 allele (OR = 0.18, 95% CI 0,039-0,8, p = 0.029) was demonstradet to be independent factor to take a longer time to reach an EDSS of 6, while HLA DRB1*01 allele (OR = 5.92, 95% CI 1,30-26,8, p = 0.021) was related in a shorter time to reach and EDSS of 6. Patients with HLA DRB1*08 allele had lower IgG index compared to patients without this allele (0.58 +/− 0.17 and 0.73 +/− 0.31, respectively, p = 0.04), and HLA DRB1*15 allele was more often found among MS patients with oligoclonal bands (OCBs) in cerebrospinal fluid than among those without OCBs (OR 2.3, CI 95% 1.017-5.301; p = 0.043).ConclusionsHLA DRB1*15 allele was related with an earlier manifestation of the first MS symptoms, progressive course of the disease and higher degree of disability. HLA DRB1*08 allele was more prevalent among the RR MS patients and was associated with the lower rate of relapse, degree of disability and IgG index.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 62%

The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania

et al. 2013

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“…In a related paper, an apparently contradictory finding was observed when patients were stratified by early versus late-onset MS (Qiu et al, 2010). Patients with lateonset MS (n ¼ 73), defined as presentation over the age of 50, were more likely to have PPMS and carry the HLA-DRB1*0801 allele compared to patients with early-onset MS (n ¼ 100).…”

Section: Recent Studies Of Hla In Ppmsmentioning

confidence: 97%

Genetics of primary progressive multiple sclerosis

Cree

2014

Handbook of Clinical Neurology

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“…Gadolinium (0.1 mg/kg) was administered in 32 cases. Brain MRI scans were performed using T1, T2, proton density and fluid attenuated inversion recovery (FLAIR) sequences in the same scanning session with a protocol published previously [17].…”

Section: Mri Protocolmentioning

confidence: 99%

Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

Qiu

Raven²,

James

et al. 2011

Journal of the Neurological Sciences

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Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

Cited by 22 publications

References 32 publications

The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania

The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania

Genetics of primary progressive multiple sclerosis

Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

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