Clinical profile and atypical manifestation of dengue fever cases between 2011 and 2018 in Chennai, India

Mohan, Kamalraj; Malaiyan, Jeevan; Nasimuddin, Sowmya; Devasir, Ravin Sathyaseelan; Meenakshi-Sundaram, PradeepRaj; Selvaraj, Santhiya; Krishnasamy, Bharathi; Gnanadesikan, Sumathi; Karthikeyan, Muthulakshmi; Kandasamy, Mohanakrishnan; Jayakumar, Nithyalakshmi; Elumalai, Dhevahi; Ra, Gokul G.

doi:10.4103/jfmpc.jfmpc_926_19

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…Serological diagnosis of dengue virus infection is normally performed by observation of the NS1 antigen and dengue IgM antibodies in the patients. Our study reported male predominance and is in harmony with the other study reported previously (10). The incidence of dengue fever in the current study was higher in the group aged 21-40 years, which was consistent with a previous study by Rabbani et al (11).…”

Section: Discussionsupporting

confidence: 93%

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Khan¹,

Sajjad²,

Mansoori³

et al. 2023

LMRJ

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Dengue virus belongs to flavivirus family which gains entry into the host organism through skin following an infected mosquito bite. Humoral, cellular, and innate host immune responses are involved in the progression of the disease. Dengue fever is getting common in Pakistan, and at times shows high mortality, but there is limited literature available. Therefore, this study was designed to evaluate hematological parameters in patients with dengue fever. This was a retrospective cross-sectional study conducted in the Department of Microbiology, Dow Diagnostic Reference and Research Laboratory, Karachi, Pakistan from 1 January 2021 till December 2021. A total of 6140 were collected, out of which 1746 were found positive. Dengue infection was confirmed by rapid screening NS1 antigen by ICT method. IgM antibodies were detected by Enzyme linked immunosorbent assay (ELISA). Hematological analysis was performed on Sysmex analyzer. Among the 1746 positive samples, 1036 (60%) were males and 710 (40%) were females. More than 10 hemoglobin and 45 hematocrits were found in greater than 40% of cases. Leucopenia less than 4000 was observed mostly in age group 0-20 years. Eosinophilia, basophilia, lymphocytosis and atypical lymphocytosis were shown equally in all age groups. Our study found greater incidence of Dengue fever among 21-40 years of age group with male predominance. Hematological spectrum revealed thrombocytopenia, lymphocytosis, high hematocrit, eosinophilia, basophilia and monocytosis at the time of diagnosis.

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Section: Discussionsupporting

confidence: 93%

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Khan¹,

Sajjad²,

Mansoori³

et al. 2023

LMRJ

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“…There was no significant difference in these parameters between dengue with or without warning signs and severe dengue. Platelet count was not correlated with bleeding manifestation, similar to other studies [6,9]. In contrast to our study, Lam et al…”

Section: Discussionsupporting

confidence: 81%

“…The majority of the patients had a fever for less than seven days (88.7%). Most previous studies have reported fever as a common symptom [5,6,8,9]. Persistent fever beyond seven days was considered to be a sign of poor prognosis in the study by Padmaprakash et al; however, we could not find any significant difference in patient outcomes with fever beyond seven days.…”

Section: Discussioncontrasting

confidence: 74%

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Dengue: A Neglected Disease of Concern

Jisamerin¹,

Mohamedkalifa²,

Gaur³

et al. 2021

Cureus

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BackgroundDengue fever, more prevalent in Asia, is a highly neglected vector-borne disease. It has a varied presentation ranging from common fever to atypical presentation as encephalitis. This study aimed to analyze the demographic and clinical profile of dengue patients admitted to a tertiary care center in Tamilnadu. MethodologyThis retrospective study was performed by collecting patient data from the medical records department for the years 2012 to 2014. A total of 150 patients with 50 patients from each year were selected. The patient's demographic data, clinical profile, management, and outcome were noted. Patients were divided into three groups as per the World Health Organization's 2009 classification. ResultsMost dengue cases occurred from October to December (70.7%). The number of male and female patients was almost equal (77 [51.3%] and 73 [48.7%], respectively). The middle-aged group (21-40 years) was commonly affected (54%). The mean age was 29 ± 13.20 years. Fever was the most common symptom (100%), followed by lethargy (81.3%) and myalgia (60.7%). Overall, 10% of patients had comorbidities such as diabetes, hypertension, and ischemic heart disease. Moreover, 22.7% of patients had dengue with warning signs, and severe dengue was seen in 19.3% of patients. A significant difference was noted in the total count, comorbidities, serositis, and the duration of hospitalization between the groups. No mortality was recorded in the study population. ConclusionsDengue is very common in the middle-aged group. Patients with severe dengue had significant leucopenia, several comorbidities, and serositis. The mortality can be reduced to <1% and even zero in severe dengue according to our study with close monitoring and supportive care.

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“… 1 Most infections are subclinical; however, in some cases, DENV infection results in a variety of clinical symptoms, ranging from mild fever (dengue fever) to dengue shock syndrome and dengue hemorrhagic fever, which is fatal. 2 , 3 Currently, no approved antiviral drugs are available to treat DENV infection; therefore, the only management option for patients is symptomatic treatment. 4 , 5 DENV infection induces the expansion of memory B cells and plasmablasts.…”

Section: Introductionmentioning

confidence: 99%

Responses of CD27⁺CD38⁺ plasmablasts, and CD24^hiCD27^hi and CD24^hiCD38^hi regulatory B cells during primary dengue virus 2 infection

Lei

Wang

et al. 2021

Clinical Laboratory Analysis

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Dengue fever, a highly infectious disease transmitted by Aedes mosquitoes, is caused by four serotypes of dengue virus (DENV), which has led to 400 million infections annually in over 100 countries. 1 Most infections are subclinical; however, in some cases, DENV infection results in a variety of clinical symptoms, ranging from mild fever (dengue fever) to dengue shock syndrome and dengue hemorrhagic fever, which is fatal. 2,3 Currently, no approved antiviral drugs are available to treat DENV infection; therefore, the only management option for patients is symptomatic treatment. 4,5 DENV infection induces the expansion of memory B cells and plasmablasts. [6][7][8][9][10] Plasmablasts further differentiate into antibodysecreting plasma cells associated with an antigen-specific B-cell

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Clinical profile and atypical manifestation of dengue fever cases between 2011 and 2018 in Chennai, India

Cited by 11 publications

References 25 publications

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Dengue: A Neglected Disease of Concern

Responses of CD27⁺CD38⁺ plasmablasts, and CD24^hiCD27^hi and CD24^hiCD38^hi regulatory B cells during primary dengue virus 2 infection

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Clinical profile and atypical manifestation of dengue fever cases between 2011 and 2018 in Chennai, India

Cited by 11 publications

References 25 publications

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Dengue: A Neglected Disease of Concern

Responses of CD27+CD38+ plasmablasts, and CD24hiCD27hi and CD24hiCD38hi regulatory B cells during primary dengue virus 2 infection

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Responses of CD27⁺CD38⁺ plasmablasts, and CD24^hiCD27^hi and CD24^hiCD38^hi regulatory B cells during primary dengue virus 2 infection