Clinical Profile, Aetiology, and Short Term Outcome of Convulsive Status Epilepticus in Children in Eastern India

Das, Niloy Kumar

doi:10.18535/jmscr/v5i1.109

Cited by 4 publications

(7 citation statements)

References 15 publications

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“…Similar risk factors were found in other studies. 5,7,11,16 Age, prior neurological status, lag time for receiving first AED and response to it did not have significant effect on mortality in present study. Gulati et al and Kumar et al reported high mortality in children less than 3 years with CSE.…”

Section: Discussioncontrasting

confidence: 50%

“…Mortality rate in children with CSE ranged from 14-33% in Indian studies while studies from developed countries report mortality of 9-11%. 5,7,8,16,18 The risk factors for mortality that were significant in this study included longer duration of status, acute symptomatic etiology, requirement of ventilatory support and circulatory impairment.…”

Section: Discussionmentioning

confidence: 85%

“…Similarly, other studies have also reported predominance of generalized seizures. [12][13][14][15][16] Acute etiologies usually have diffuse involvement which could describe the preponderance of generalized seizures.…”

Section: Discussionmentioning

confidence: 99%

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Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

Madhu

Krithika

2019

Int J Contemp Pediatr

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Background: The outcome of status epilepticus (SE) depends on various determinants such as age, type and duration of SE, etiology, management and associated comorbidities. This study was undertaken to describe the clinical profile and outcome of children with convulsive status epilepticus presenting to pediatric intensive care unit (PICU).Methods: Eighty-seven children between the age group 1 month to 12 years who at presentation or during the PICU stay had convulsive status epilepticus (CSE) were included in the study. Clinical profile, etiological spectrum and outcome at the end of hospital stay were analysed.Results: Median age of CSE was 4 years and 55 (63.2%) were below 5 years of age. Acute symptomatic etiology of CSE was a significant risk factor (p= 0.03) for refractory status epilepticus (RSE) which was seen in 31 patients (39%). Acute symptomatic etiology was the cause of CSE in 46 (59.2%) children. Remote symptomatic (26.4%), cryptogenic (18.4%) and progressive (2.3%) were other etiologies. Neuro-infection (29.8%) and febrile seizures (11.5%) were the most common acute symptomatic causes. Mortality and morbidity occurred in 23 (26.4%) and 8 (9.2%) patients respectively. Remaining 56 (64.6%) returned to baseline condition at the end of hospital stay. Longer duration (p= 0.03) and acute symptomatic etiology (p=0.049) were significant risk factors for mortality.Conclusions: Most common causes of CSE in children are acute symptomatic. Longer duration of status is associated with higher mortality. Hence, termination of seizure activity at the earliest, prudent management of respiratory or circulatory impairments in these children and improving the overall health care to prevent neuro-infections are important steps to improve outcome.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 85%

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Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

Madhu

Krithika

2019

Int J Contemp Pediatr

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“…Das et al also observed that fever was most common symptom associated with SE and mostly seen in younger age group of children <5 years 8. This may be because acute infections are important cause of SE in all age groups.…”

mentioning

confidence: 92%

“…In our study mortality of SE was 8.7%. Das et al observed mortality of 15% (n=6/40) 8. Madhu et al observed mortality of 26.4% (n=23/87) and Kumar et al observed mortality of 31.4% (n=22/70).…”

mentioning

confidence: 99%

Evaluation and assessment of clinical and demographic profile, aetiology and outcome of status epilepticus in paediatric patients

Garasiya¹,

Patel²

2023

Int J Contemp Pediatr

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Background: Status epilepticus (SE) is one of the most frequent neurological emergencies that require prompt diagnosis and treatment. If not managed promptly, it may result in significant neurological morbidity and mortality. Methods: It is prospective observational study. Study for clinical and demographic profile, aetiology, outcome in patient of status epilepticus. Results: Occurrence of SE is in indoor paediatric patients was 2.05%. Male and female M: F ratio is 1.3:1. Fever was common associated symptoms in SE. The commonest type of seizure was generalised tonic-clonic seizure (GTCS). Infective etiology was most common amongst patients with SE. secondary epilepsy with CP was second most common cause followed by complex febrile seizure and primary epilepsy. In infants, metabolic etiology was the most common cause for SE. Majority of seizures were controlled only by benzodiazepines. Requirement of midazolam infusion was only in few patients and requirement of anesthetic agent was rare. Mechanical ventilation was frequently required in patients with refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE). Mortality was almost same in all age groups with SE. Mortality was directly proportional to duration of the SE and was highest in patient having >30 minutes of duration of seizure. Conclusions: SE was more commonly associated with male gender and age <5 years. By improving hygiene, nutritional and vaccination status, overcrowding and education, we can reduce occurrence of SE, by reducing infections. Mortality can be reduced by immediate control of seizure and improving intensive care facilities.

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The etiologies and outcome of convulsive status epilepticus in children at tertiary care hospital Kashmir India

Syed Muzamil Mehraj,

Suhail Ahmad Naik,

Shafat Tak

2023

Asian J Med Sci

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Background: Convulsive status epilepticus (CSE) is a common neurological emergency, where immediate supportive and specific treatment determines the outcome of the patient. Therefore, immediate management and etiological workup of CSE should be done in tandem to decrease associated morbidity and mortality. Aims and Objectives: The study aimed to ascertain different etiologies and outcomes of CSE in children. Materials and Methods: The study was a prospective observational hospital-based study conducted in a tertiary care hospital from October 2020 to September 2022. Results: The most common type of seizure in CSE was GTCS, 154 cases (83.7%), followed by focal seizure 12 % (26 cases). Almost 35% of patients had CSE as a first presentation for PICU admission and the rest 65% of patients did have a previous history of seizures. The most common etiology of CSE was remote symptomatic, seen in 27.2%, followed by acute central nervous system infection in 19.5%, febrile status in 19.5%, and cryptogenic/idiopathic SD in 14.9%. Among the patients who had encephalitis, the common etiologies were enteroviruses and herpes simplex. We did not find any case of Japanese encephalitis, West Nile encephalitis, cerebral malaria, or dengue case in our study. Therefore, recommending cerebrospinal fluid panels for these vectors borne viral brain diseases is a waste of resources in Kashmir, India. Furthermore, we did not find any case of neurocysticercosis in our study as a cause of CSE. Conclusion: In our study, we had 16 cases of encephalitis, and most of them were caused by enteroviruses and herpes simplex virus. We did not find any case of Japanese encephalitis, West Nile encephalitis, cerebral malaria, or dengue case in our study. Vector-borne diseases transmitted by different mosquitoes do not occur in Kashmir.

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Clinical Profile, Aetiology, and Short Term Outcome of Convulsive Status Epilepticus in Children in Eastern India

Abstract: Abstract

Cited by 4 publications

References 15 publications

Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

Evaluation and assessment of clinical and demographic profile, aetiology and outcome of status epilepticus in paediatric patients

The etiologies and outcome of convulsive status epilepticus in children at tertiary care hospital Kashmir India

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