Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children

Rodriguez, Leonel; Irani, Katayun; Jiang, Hongsheng; Goldstein, Allan M.

doi:10.1097/mpg.0b013e318248ed3f

Cited by 53 publications

(114 citation statements)

References 25 publications

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“…A recent report characterized gastroparesis as a complication of lung transplantation, particularly in individuals who develop bronchiolitis obliterans [12]. Children may develop gastroparesis from viral infection (18%) or mitochondrial dysfunction (8%) [13]. Affected infants are predominantly boys; most adolescent gastroparetics are girls.…”

Section: Key Pointsmentioning

confidence: 98%

Gastroparesis

Hasler¹

2012

Current Opinion in Gastroenterology

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Section: Key Pointsmentioning

confidence: 98%

Gastroparesis

Hasler¹

2012

Current Opinion in Gastroenterology

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“… Re (2012) SR (in neonates) (2005) RC, DB, PC—no difference (2003) RC, DB, PC—no difference (2003) RC, DB, vs metoclopramide study (2001) RC, DB, PC—accelerated gastric emptying (2001) P, RC, DB, PC—improved enteral feeding (2001) RC, DB, PC—improved gastric emptying (2001) RC, DB, PC—no difference (2000) RC, DB—no difference (1998) …”

Section: Treatment Optionsmentioning

confidence: 99%

“…Rodriguez et al showed that domperidone administration resulted in 74% of pediatric patients with GP reporting a positive response and 26% reporting complete symptom resolution, the highest rate among prokinetic drugs. In this study, domperidone resulted in less adverse events (6%) when compared to metoclopramide .…”

Section: Treatment Optionsmentioning

confidence: 99%

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Childhood gastroparesis is a unique entity in need of further investigation

Febo‐Rodriguez

Chumpitazi

Shulman

2019

Neurogastroenterology Motil

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Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures. Purpose The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.

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“…Nausea, vomiting, abdominal pain, weight loss and post-prandial fullness are the most common symptoms, and can be treated with dietary modification with a combination of acid suppression therapy, prokinetic and anti-emetic drugs 6 . In the most severe cases, patients require surgical intervention and supplemental nutrition by post-pyloric feeding.…”

Section: Introductionmentioning

confidence: 99%

Gastric Pacing in a Child with Severe Gastroparesis and Review of the Literature

Ong

Logarajah

2012

Proceedings of Singapore Healthcare

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Gastroparesis is a disorder characterised by symptoms of and evidence for gastric retention in the absence of mechanical obstruction. Symptoms include nausea and vomiting, early satiety, postprandial fullness, regurgitation and abdominal pain. Common causes of gastroparesis are diabetes, post-surgical and idiopathic. In some patients, gastroparesis can be very severe and refractory to medical therapy including anti-emetics, anti-reflux and pro-kinetic medications. Gastric electrical stimulation represents a novel treatment for severe gastroparesis by regulating gastric electrical dysfunction with a neurostimulator. In adult studies, vomiting frequency has been reduced by up to 81% from baseline. We report a case of a 13-year-old girl with life-long severe idiopathic gastroparesis who was successfully treated by gastric pacing.

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Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children

Abstract: Pediatric gastroparesis is a complex condition with variable symptomatology and outcome depending on multiple parameters. Understanding the clinical features and response to therapy will improve our diagnosis and treatment of this disorder.

Cited by 53 publications

References 25 publications

Gastroparesis

Gastroparesis

Childhood gastroparesis is a unique entity in need of further investigation

Gastric Pacing in a Child with Severe Gastroparesis and Review of the Literature

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