Clinical presentation and management of Fasciola hepatica infection: Single-center experience

Kaya, Muhsin; Beştaş, Remzi; Çetin, Sedat

doi:10.3748/wjg.v17.i44.4899

Cited by 94 publications

(91 citation statements)

References 16 publications

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“…Acute symptoms are caused by the tissue destruction and acute inflammation associated with larval migration through intestine, peritoneum and liver parenchyma, as well as a generalised allergic reactions to parasite antigens (5) . Fever and abdominal pain (which may be excruciating), are the most frequently reported symptoms (5,77). Anorexia, flatulence, nausea, diarrhoea, urticaria and cough are also common.…”

Section: Fascioliasismentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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Section: Fascioliasismentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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“…In patients admitted in the biliary phase, abdominal pain, pain in the upper right quadrant, biliary colic, jaundice associated with the obstruction of bile ducts by the adult parasite, and inflammatory response were the most common complaints [18]. In this phase, serum ALP, GGT, and total bilirubin values were elevated, consistent with cholestasis [19].…”

Section: Discussionmentioning

confidence: 72%

“…ERCP and sphincterotomy are used to extract parasites from the biliary tree [23]. In the literature, it was reported that patients in the biliary phase may admit to the hospital due to acute pancreatitis as well [18]. In our three patients who had a diagnosis of biliary phase fascioliasis, parasites were seen and extracted with ERCP after USG; abdominal CAT was not performed.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey

Boşnak

Karaoğlan

Şahin

et al. 2016

J Infect Dev Ctries

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Introduction: In this study, clinical, laboratory, radiological, and serological examinations of fascioliasis patients were analyzed, and data with a significant impact on differential diagnosis were evaluated. Methodology: Clinical, radiological, and laboratory findings and treatment responses of a total of 22 fascioliasis patients, treated between October 2009 and September 2014, were evaluated. Nineteen patients were diagnosed with fascioliasis at the invasive phase and three patients at the chronic phase. Patients were followed up for clinical, laboratory, and radiology findings for a period of three months to one year after treatment. Results: The most frequent complaints in both groups were abdominal pain, and the most common physical examination finding was epigastric tenderness. In the performed examination, an eosinophil elevation in whole blood count was detected in 19 patients (100%) in the hepatic phase, and in 2 patients (66.6%) in the biliary phase. The results of the Fasciola hepatica indirect hemagglutination assay (IHA) test ordered in the diagnosis were positive in all patients. Treatment with 10 mg/kg/day triclabendazole for two consecutive days was effective. Live parasites were extracted from patients in the biliary phase with endoscopic retrograde cholangiopancreatography. In the follow-ups, remission in IHA titer and clinical and radiological improvement was achieved in all patients. Conclusions: If hypereosinophilia is detected by peripheral smear in patients who are admitted with complaints such as abdominal pain, weakness, nausea, myalgia, and weight loss, radiological evaluation and serological tests should be performed and fascioliasis should be considered in the differential diagnosis.

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“…We suspect that many of the children with eosinophilia may have had acute or chronic Fasciola infection. 24,25 Testing of one stool specimen probably limited our ability to detect low-intensity infections. Furthermore, Marcos and others 13 described a strong association between eosinophil counts and Fasciola infection in highly endemic areas.…”

Section: Discussionmentioning

confidence: 99%

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cabada¹,

Goodrich²,

Graham³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. There are limited data about the epidemiology of fascioliasis in Cuzco, Peru. We studied children 3-12 years old from six communities in the highlands of Cuzco to evaluate the epidemiology of fascioliasis; 227 children were included, one-half were female, the mean age was 7.5 (±2.6) years, and 46.2±% had one or more parasites, including Fasciola (9.7%), Ascaris (12.8%), Hymenolepis (9.3%), Trichuris (1.3%), hookworm (1.8%), Strongyloides (0.9%), and Giardia (27.8%). Fasciola was associated with the number of siblings in the household, drinking untreated water, and giardiasis. Eosinophilia was encountered in 21% of children and more common in those drinking untreated water at home and those infected with a parasite, but the differences were not significant. Eating water plants was not associated with Fasciola or eosinophilia. Fascioliasis and eosinophilia were common in the highlands of Cuzco. Fascioliasis was associated with socioeconomic factors and drinking water. BACKGROUND

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Clinical presentation and management of Fasciola hepatica infection: Single-center experience

Abstract: Fasciola hepatica infection should be considered in the differential diagnosis of patients with hepatic or biliary disease and/or acute pancreatitis associated with eosinophilia.

Cited by 94 publications

References 16 publications

Human liver flukes

Human liver flukes

Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey

Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

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