Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cabada, Miguel M.; Goodrich, Mary R.; Graham, Brittany; Villanueva‐Meyer, Pablo G.; López, Martha; Arque, Eulogia; White, A. Clinton

doi:10.4269/ajtmh.14-0169

Cited by 22 publications

(28 citation statements)

References 19 publications

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“…El-Sanh showed that children from mothers with Fasciola were three times more likely to be infected than children from negative mothers. 12 Cabada et al 13 reported that socioeconomic markers such as number of siblings and years of education of the father were associated with a higher prevalence of Fasciola infection among children in the Cusco region. Even in highly endemic areas, the distribution can vary markedly between adjacent communities as documented in a few large community studies.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Cabada

Morales

Webb

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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is the most widely distributed trematode-affecting humans. The Andes Mountains are highly endemic for fascioliasis. We report results of a cross-sectional study evaluating the epidemiology of Fasciola among children in 26 agricultural communities in the Cusco region of Peru. Children 3 to 16 years old were enrolled in preschools and schools. Blood from participants was tested for complete blood counts, transaminases, and Fasciola antibodies. Stool samples were tested for Fasciola and other parasites. A total of 2,515 children were included in the analysis and the mean age was 9.6 years (±3.6). Ten percent (253) of the children had at least one positive test for Fasciola, 6% had chronic infection, and 0.4% acute infection. The rest of the subjects had only antibodies against Fasciola. The prevalence of infection varied from 0% to 20% between communities. Children with evidence of Fasciola exposure were older, lived at higher altitudes, and had a lower socioeconomic status than children without infection. The logistic regression analysis showed that children from Ancahuasi district, older children, and children with higher measures of poverty were more likely to have Fasciola exposure. Fascioliasis is common in the Cusco region and associated with poverty. However, the distribution varies markedly between communities.

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Section: Introductionmentioning

confidence: 99%

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Cabada

Morales

Webb

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…La fascioliasis humana representa en el Perú un problema de salud pública, tiene una prevalencia global de 24,3% en el altiplano peruano, reportado en el 2002 mediante estudio coproparasitológico, y hasta un 71,4% con serología positiva para el 2004 (7) ; está presente en 18 de las 24 regiones del país, aunque se estima que existe una gran cantidad de casos subclínicos sin diagnosticar (8) . Las regiones con mayores prevalencias (9) son Puno (Asillo) con 51,9% (10) , Cajamarca entre 6,3 y 47,7% (11) , Arequipa con 27% (12) , Junín entre 0,9 a 11,7% (13) y Cusco entre 9,7 y 10,3% (14) .…”

Section: Introductionunclassified

Rendimiento diagnóstico del Western Blot para detectar simultáneamente anticuerpos en pacientes con cisticercosis, hidatidosis y fascioliasis humana

Davelois¹,

Escalante²,

Jara

2016

Rev Peru Med Exp Salud Publica

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. To determine the diagnostic yield using western blotting to simultaneously detect antibodies in patients with human cysticercosis, hydatidosis, and human fascioliasis. Materials and methods . Cross-sectional study of diagnostic yield assessment. Excretory/secretory antigens were obtained from Taenia solium larvae, Echinococcus granulosus cysts, and the adult flukes of Fasciola hepática, which were then separated using the polyacrylamide gel electrophoresis technique, transferred, and attached to a nitrocellulose membrane to be probed with sera from the patient infected with the three parasites. The sensitivity of the technique was assessed using 300 individual serum samples, 60 pools of two parasites, and 20 pools of three parasites with 75 sera from patients with other parasites, 10 from patients with other diseases, and 15 from patients without parasites. Results . The technique revealed 13 glycoproteins (GP): GP 35, 31, 24, 23, 18, 17, 14, and 13 kDa for cysticercosis; GP 8, 16, and 21 kDa for hydatidosis; and GP 17 and 23 kDa for fascioliasis. The test detected the presence of antibodies with a sensitivity of 96% (95% confidence interval [CI] = 94.62-98.54%) in the detection of one or the thirteen bands, a specificity of 100% (95% CI = 99.50-100.00%); individually, there was a sensitivity for cysticercosis of 97% (95% CI = 93.16-100.00%), for hydatidosis of 94% (95% CI = 88.85-99.15%) and for fascioliasis of 96% (95% CI = 91.66-100.00%). Conclusions . Western blotting is effective in the simultaneous detection of antibodies in patients with human cysticercosis, hydatidosis, and fascioliasis, and it can be used as a diagnostic test to either rule out or confirm the presence of antibodies in endemic areas.

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“…The disease can lead to liver cirrhosis, liver failure and biliary tract obstruction (1). Fascioliasis is mostly seen in England and Ireland in Europe, northern Iran, northern Africa, Egypt, Cuba, especially the Peruvian and Bolivian Andes in South America (2). …”

Section: Introductionmentioning

confidence: 99%

Fasciola Hepatica Mimicking Malignancy on 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

Sürücü¹,

Demir²,

Dülger³

et al. 2016

Mirt

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A 48-year-old female with complaints of gastrointestinal symptoms such as abdominal pain, fatigue, vomiting, nausea, and weight loss was diagnosed with neuroendocrine tumor after removal of a 2 mm lesion from the stomach with endoscopic biopsy. Her magnetic resonance imaging that was performed due to on-going symptoms showed multiple linear hypointense lesions in the liver. Positron emission tomography/computed tomography (PET/CT) scan was performed for differential diagnosis, which showed high fluorodeoxyglucose (FDG) uptake in these lesions. Clinical and laboratory findings revealed the final diagnosis as Fasciola hepatica. The imaging features of this case is presented to aid in differentiating this infectious disease from malignancy and avoid misdiagnosis on FDG-PET/CT.

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Fascioliasis and Eosinophilia in the Highlands of Cuzco, Peru and Their Association with Water and Socioeconomic Factors

Cited by 22 publications

References 19 publications

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru

Rendimiento diagnóstico del Western Blot para detectar simultáneamente anticuerpos en pacientes con cisticercosis, hidatidosis y fascioliasis humana

Fasciola Hepatica Mimicking Malignancy on 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

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