Clinical Predictors of 1-Year Outcome in Schizophrenia

Abstract

To assess clinical predictors of 1-year outcome in schizophrenia, 63 patients were studied prospectively. Persistent negative and total symptoms after 4 weeks of neuroleptic treatment accounted for 62% of the variance of 1-year outcome, whereas baseline measures showed no relationship to outcome. Thus, 1-year outcome in schizophrenia can be reasonably predicted on the basis of symptoms persisting after 4 weeks of treatment.

A multi‐site Canadian perspective: examining the functional outcome from first‐episode psychosis

“…Six‐month rather than baseline scores for PANSS were used as independent variables given the literature suggesting that baseline measures may not be predictive of 1 year outcome (27, 28), and that the use of early (baseline) measures diminishes the predictive capacity of a model (29, 30), likely related to their transient nature.…”

Neuropsychological Prediction of Treatment Efficacy and One-Year Outcome in Schizophrenia

“…In the present study, baseline attention was found to be strongly related to treatment responsiveness of negative symptoms. The preliminary finding that posttreatment clini cal measures best predicted to outcome [2] suggests that baseline evaluations may be state markers that are affected by illness acu ity. Baseline neuropsychological evaluations may therefore be less effective in projecting to longer-term outcome [18].…”

“…Residual negative symptoms in schizo phrenia are associated with poor treatment response and deficient long-term outcome [ 1,2], Negative symptoms are also associated with poor performance on neurocognitive measures in both medicated and nonmedicated schizophrenic patients [3,4], The pur pose of the present study was to establish the degree of interrelationship between neuropsy chological functioning in the acute phase of the illness, clinical measures of treatment re sponse (pre-and posttreatment positive and negative symptoms), and 1-year outcome. We hypothesized that the presence of negative symptoms is associated with impaired cogni tive status and poor 1-year outcome.…”

Managed mental health care: problems and possibilities

“…Deterioration is not always progressive although the relationship between relapse and further deterioration is unclear (Johnstone & Lang 1994). There are no reliable prognostic criteria to assess the disease progression and outcomes for this illness although certain factors, such as age of onset (Mayer et al 1995), psychopathology at discharge (Hwu et al 1995), response to medication (Ribeiro et al 1992), and genderrelated differences (Goldstein 1993) are known to be important. The picture is further complicated by the presence of positive and negative symptoms at different stages during the patient's illness trajectory.…”